Patents by Inventor Georg Jager

Georg Jager has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacture of LH-RH and LH-RH analogs using Glu-His(DnP)-OH
    Patent number: 4275001
    Abstract: What is disclosed is a method for the manufacture of LH-RH and LH-RH analogs, which comprises reacting Glu-His(DnP)-OH with the corresponding peptide having a free amino group and protected carboxy groups in a solvent as used in peptide chemistry and with the addition of 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine (HOObt) and a carbodiimide and then splitting off the Dnp-(2,4-dinitrophenyl) group. The new method greatly reduces the degree of histidine racemization. The invention also provides a new dipeptide, i.e. Glu-His(Dnp)-OH.
    Type: Grant
    Filed: February 12, 1980
    Date of Patent: June 23, 1981
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wolfgang Konig, Volker Teetz, Georg Jager, Rolf Geiger