Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

Abstract: Among other things, the present disclosure provides technologies for modulating complement activation. In some embodiments, the present disclosure provides compounds that inhibit C3 convertase activity. In some embodiments, the present disclosure provides methods for treating complement-mediated conditions, disorders or diseases. In some embodiments, the present disclosure provides methods for treating conditions, disorders or diseases mediated by C3 convertase.

Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

Abstract: The present invention relates to compounds of formula (I) wherein Q is selected from O or S; R1 is a saturated or unsaturated, optionally substituted hydrocarbyl group optionally including one or more heteroatoms N, O or S; R2 is a cyclic group substituted at the a and a? positions, wherein the substituent at the ?-position is a monovalent heterocyclic group or a monovalent aromatic group, wherein the heterocyclic or aromatic group may optionally be substituted, and wherein the cyclic group may optionally be further substituted; R3 and R4 are each independently hydrogen, halogen, —OH, —NH2, —CN, —R5, —OR5, —NHR5 or —N(R5)2; or R3 and R4 together with the carbon atom to which they are attached may form a 3- to 7-membered saturated or unsaturated, optionally substituted cyclic group; and R5 is independently optionally substituted C1-C4 alkyl.

Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

Abstract: The present invention relates to compounds of formula (I) wherein Q is selected from O or S; R1 is a saturated or unsaturated, optionally substituted hydrocarbyl group optionally including one or more heteroatoms N, O or S; R2 is a cyclic group substituted at the a and a? positions, wherein the substituent at the ?-position is a monovalent heterocyclic group or a monovalent aromatic group, wherein the heterocyclic or aromatic group may optionally be substituted, and wherein the cyclic group may optionally be further substituted; R3 and R4 are each independently hydrogen, halogen, —OH, —NH2, —CN, —R5, —OR5, —NHR5 or —N(R5)2; or R3 and R4 together with the carbon atom to which they are attached may form a 3- to 7-membered saturated or unsaturated, optionally substituted cyclic group; and R5 is independently optionally substituted C1-C4 alkyl.

Abstract: A flatbed punching module for punching a printing material includes an upper platen and a lower platen which can be moved by a drive relative to the upper platen that is fixed to a frame, in order to perform a punching stroke for punching the printing material passing between the upper platen and the lower platen, resulting in the lower platen engaging with or being thrown onto the upper platen. As a result, the printing material can be processed through the use of at least one punching die. At least one printing material transport device for guiding the printing material, is held fixedly on the movable lower platen. The flatbed punching module can advantageously be used in a flatbed punch for processing a printing material web.

Abstract: A flatbed punching module for punching a printing material includes an upper platen and a lower platen which can be moved by a drive relative to the upper platen that is fixed to a frame, in order to perform a punching stroke for punching the printing material passing between the upper platen and the lower platen, resulting in the lower platen engaging with or being thrown onto the upper platen. As a result, the printing material can be processed through the use of at least one punching die. At least one printing material transport device for guiding the printing material, is held fixedly on the movable lower platen. The flatbed punching module can advantageously be used in a flatbed punch for processing a printing material web.