Abstract: Preparation of optionally substituted dihydroisoquinolines. The present invention relates to a process for the preparation of optionally substituted dihydroi-soquinolines of the formula I.

Abstract: A method performed by one or more devices includes determining an information item indicative of at least one parameter affecting the treatment of a textile with the information item being detected by an information carrier of the textile (220) and/or a cleaning device (230), or a cleaning agent (210) and the textile (220), or the cleaning agent (210) and the cleaning device, or the cleaning agent (210) and the textile (220) and the cleaning device and the information carrier comprises a package, a label, an NFC chip or a combination thereof, determining at least one treatment parameter of the textile based at least in part on the determined information item, and outputting or triggering the outputting of the at least one determined treatment parameter.

Abstract: A damping material 10 for a damping layer or interlayer of a brake lining has at least one rubber content and one resin content. A plurality of macroscopic, heterogeneously delimited areas are formed in the damping material 10, areas comprising rubber areas 1 with a high rubber content of at least 3% to maximally 50% by weight, and resin areas 2 with a high resin content of at least 5% by weight, wherein the rubber areas 1 are free of resin or have a resin content ?5% by weight, and the resin areas 2 are free of rubber.

Abstract: This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

Abstract: The invention proposes a method for operating a metering system (32) with a plurality of metering valves (34, 35) for an SCR catalyst system, in which opening times for the injection of reducing agent are calculated for the metering valves (34, 35) based on a metering amount requirement. In the calculations of the opening times, a metering-valve-specific adaptation factor is used, w herein a deviation (?p) of a system pressure (pist) in the metering system (32) from a target pressure (psoll) and a weighting factor are used for calculation of the metering-valve-specific adaptation factor. The weighting factor depends on a proportion (r34, r35) of the required metering amount ((formula (I)), (formula (II)) of the respective metering valve (34,35) in relation to a total metering amount ((formula (I)), (formula (II)) of all metering valves (34, 35).

Abstract: The present invention relates to novel 2-[thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamides of formula A and pharmaceutically acceptable salts thereof, wherein R1 to R3 are as defined herein. The invention also relates to processes for the preparation of these compound, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment or prevention of conditions in which inhibition of the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme may be beneficial.

Abstract: A method operates a braking device for motor vehicles, in particular for utility vehicles. Along a trailer supply line for supplying air to a parking brake of a trailer and/or a trailer control line for supplying air to an operating brake of a trailer, the air pressure is measured by at least one pressure transducer and is transmitted in the form of an electric signal to an electronic control unit of the motor vehicle. In the event of a faulty pressure change response, an open trailer supply line and/or an open trailer control line is detected.

Abstract: The invention proposes a method for operating a metering system (32) with a plurality of metering valves (34, 35) for an SCR catalyst system, in which opening times for the injection of reducing agent are calculated for the metering valves (34, 35) based on a metering amount requirement. In the calculations of the opening times, a metering-valve-specific adaptation factor is used, w herein a deviation (?p) of a system pressure (pist) in the metering system (32) from a target pressure (psoll) and a weighting factor are used for calculation of the metering-valve-specific adaptation factor. The weighting factor depends on a proportion (r34, r35) of the required metering amount ((formula (I)), (formula (II)) of the respective metering valve (34,35) in relation to a total metering amount ((formula (I)), (formula (II)) of all metering valves (34, 35).

Abstract: A low-pressure cryogenic fluid sampling system includes a cryogenic sample handle assembly; a transfer and vaporization tubular loop; and a sample vessel. The sample handle assembly connects to a cryogenic storage vessel containing a cryogenic fluid. The tubular loop connects to the cryogenic sample handle assembly. The sample vessel removably connects to the transfer and vaporization tubular loop and accommodates a gaseous sample having a pressure lower than about 200 kPa. A method of collecting a gaseous sample with the sampling system includes purging the sample vessel; actuating the handle to purge and refrigerate the tubular loop; extracting a volume of a cryogenic fluid from the storage vessel into the loop to vaporize the cryogenic fluid and produce a gaseous sample; and transferring the sample from the tubular loop into the sample vessel. The sampling system is safer, maintains stoichiometric quantities in the cryogenic liquid, and reduces cross contamination.

Abstract: The present invention relates to novel 2-[thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamides of formula A and pharmaceutically acceptable salts thereof, wherein R1 to R3 are as defined herein. The invention also relates to processes for the preparation of these compound, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment or prevention of conditions in which inhibition of the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme may be beneficial.

Abstract: Aluminum alloys, in particular Al magnesium or Al titanium alloys, are suitable as corrosion protection media in friction linings for automotive brakes and couplings, and serve as a replacement for zinc metal or zinc compounds in such linings.

Abstract: This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

Abstract: A damping material 10 for a damping layer or interlayer of a brake lining has at least one rubber content and one resin content. A plurality of macroscopic, heterogeneously delimited areas are formed in the damping material 10, said areas comprising rubber areas 1 with a high rubber content of at least 3% to maximally 50% by weight, and resin areas 2 with a high resin content of at least 5% by weight, wherein the rubber areas 1 are free of resin or have a resin content ?5% by weight, and the resin areas 2 are free of rubber.

Abstract: A method for operating an ore comminution circuit is provided. The method includes obtaining at least one sensor signal related to an ore feed to the comminution circuit; determining a first ore grindability parameter of the ore feed from the at least one sensor signal, using a model; determining a second ore grindability parameter using parameters of the comminution circuit and/or of at least one comminution device in the comminution circuit; and updating the model with the second ore grindability parameter and the at least one sensor signal.

Abstract: This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

Abstract: The optical interferometric sensor device comprises an integrated beam splitter having a first facet and a second facet with optical ports arranged therein. On the beam splitter, the beam splitting junctions as well as the optoelectronics-side ports and the sensing-side port are arranged with a mutual displacement along the direction of the first facet. This displacement reduces undesired interference effects caused by stray light. Also, a quarter-wave retarder is provided in a recess of the beam splitter with layers of soft adhesive adjacent to it in order to reduce stress.

Abstract: A method operates a braking device for motor vehicles, in particular for utility vehicles. Along a trailer supply line for supplying air to a parking brake of a trailer and/or a trailer control line for supplying air to an operating brake of a trailer, the air pressure is measured by at least one pressure transducer and is transmitted in the form of an electric signal to an electronic control unit of the motor vehicle. In the event of a faulty pressure change response, an open trailer supply line and/or an open trailer control line is detected.

Abstract: A fiber optic sensor and related method are described, with the sensor including a cross-coupling element in the optical path between a polarizing element and a sensing element, but separated from the sensing element itself; with the cross-coupling element generating a defined cross-coupling between the two orthogonal polarization states of the fundamental mode of a polarization maintaining fiber guiding light from the light source to the sensing element thus introducing a wavelength-dependent or temperature-dependent sensor signal shift to balance wavelength-dependent or temperature-dependent signal shifts due to other elements of the sensor, particularly signal shifts due to the wavelength dependence of the Faraday effect or the electro-optic effect constant.