Abstract: The invention relates to a method for providing a structuring fat by the interesterification of a first fat with a high content of saturated long chain fatty acids with a second fat or oil to provide triglyceride compositions having an increased level of H-type fatty acids, especially C18:0 at the 2-position, the triglyceride compositions thus obtained and spreads made therefrom.

Abstract: The invention relates to a method for providing a structuring fat by the interesterification of a first fat with a high content of saturated long chain fatty acids with a second fat or oil to provide triglyceride compositions having an increased level of H-type fatty acids, especially C18:0 at the 2-position, the triglyceride compositions thus obtained and spreads made therefrom.

Abstract: The present invention relates to a nucleic acid molecule encoding a chain myeloid capable of specifically binding to CD33, CD16 and CD123, wherein said nucleic molecule comprises: (a) a nucleic add molecule encoding a protein represented by SEQ ID NO:1; (b) a nucleic acid molecule represented by SEQ ID NO:2; (c) the nucleic add molecule of (b), wherein each thymine is replaced by urea; (d) a nucleic acid molecule encoding a protein having at least 98% sequence identity to the protein of (a); or (e) a nucleic add molecule that is degenerate with respect to the nucleic acid molecule of (b) or (c). The present invention further relates to a vector comprising the nucleic acid molecule of the invention, a host cell transformed or transfected with the nucleic acid molecule or the vector of the invention, as well as to a method for the production of a single chain myeloid capable of specifically binding to CD33, CD16 and CD123.

Abstract: The invention relates to a method for providing a structuring fat by the interesterification of a first fat with a high content of saturated long chain fatty acids with a second fat or oil to provide triglyceride compositions having an increased level of H-type fatty acids, especially C18:0 at the 2-position, the triglyceride compositions thus obtained and spreads made therefrom.

Abstract: Systems and methods for damping vibrations of downhole systems are described. The systems include a downhole component configured to be disposed downhole and a shock-damping system at least one of on or in the downhole component, the shock-damping system configured to reduce torsional oscillations of the downhole component by imparting a selected shock to the downhole component. The selected shock is selected to generate damping of the torsional oscillations of the downhole system.

Abstract: Disclosed is a method and apparatus for manufacturing a continuous web of polymeric membrane and for continuous downstream processing of said web. The apparatus (10) comprises: a casting station (20) for casting the continuous web (M); a carrier (24) for carrying the web downstream; a membrane drier (30) downstream of the carrier, for drying the web; and a brushing station (40) downstream of the drier for brushing the web. Said drier is located immediately downstream of the carrier, and upstream of said brushing station. The apparatus (10) further includes an additional drying station (50) downstream of the brushing station (40). Brushing after drying retains more surfactant in the membrane which is useful for certain applications. In addition, initial drying eliminates virtually all solvents from the membrane, but leaves some non-solvent (e.g. water) within it, which in turn fixes the surfactant on the nitrocellulose fibers, which improves significantly the consistency and reproducibility of the membrane.

Abstract: The present invention relates to a novel method of preparing copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride. The present invention also relates to copanlisib dihydrochloride hydrates as compounds.

Abstract: The present invention relates:—to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof;—to methods of preparing said dihydrochloride salt;—to said dihydrochloride salt for the treatment and/or prophylaxis of a disease;—to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer;—to a pharmaceutical composition comprising said dihydrochloride salt; and—to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agent

Abstract: The present invention relates to a novel method of preparing copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride. The present invention also relates to copanlisib dihydrochloride hydrates as compounds.

Abstract: The present invention relates to a novel method of preparing copanlisib, and copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib.

Abstract: Disclosed is a method and apparatus for manufacturing a continuous web of polymeric membrane and for continuous downstream processing of said web. The apparatus (10) comprises: a casting station (20) for casting the continuous web (M); a carrier (24) for carrying the web downstream; a membrane drier (30) downstream of the carrier, for drying the web; and a brushing station (40) downstream of the drier for brushing the web. Said drier is located immediately downstream of the carrier, and upstream of said brushing station. The apparatus (10) further includes an additional drying station (50) downstream of the brushing station (40). Brushing after drying retains more surfactant in the membrane which is useful for certain applications. In addition, initial drying eliminates virtually all solvents from the membrane, but leaves some non-solvent (e.g. water) within it, which in turn fixes the surfactant on the nitrocellulose fibers, which improves significantly the consistency and reproducibility of the membrane.

Abstract: The present invention relates to a novel method of preparing copanlisib, and copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib.

Abstract: The present invention relates to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof; and to its use for the treatment of non-Hodgkin's lymphoma.

Abstract: The present invention relates to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof; and to its use for the treatment of non-Hodgkin's lymphoma.

Abstract: A method is provided for connecting at least one further steam generator to a first steam generator in a power plant. The power plant includes at least two steam generators and a steam turbine, in which a fluid used to drive the steam turbine is conveyed in a fluid circuit having a plurality of steam systems. The steam systems are assigned individual steam generators and are able to be separated from one another by shut-off valves. The fluid of at least the first steam generator is connected to the steam turbine. The method involves opening the shut-off valve of at least one first steam system of the at least one further steam generator before the steam of the at least one further steam generator has reached approximately the same steam parameters as the steam of the first steam generator, so that steam can flow into the further steam generator.

Abstract: The present invention relates:—to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof;—to methods of preparing said dihydrochloride salt;—to said dihydrochloride salt for the treatment and/or prophylaxis of a disease;—to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer;—to a pharmaceutical composition comprising said dihydrochloride salt; and to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agent

Abstract: A method is provided for connecting at least one further steam generator to a first steam generator in a power plant. The power plant includes at least two steam generators and a steam turbine, in which a fluid used to drive the steam turbine is conveyed in a fluid circuit having a plurality of steam systems. The steam systems are assigned individual steam generators and are able to be separated from one another by shut-off valves. The fluid of at least the first steam generator is connected to the steam turbine. The method involves opening the shut-off valve of at least one first steam system of the at least one further steam generator before the steam of the at least one further steam generator has reached approximately the same steam parameters as the steam of the first steam generator, so that steam can flow into the further steam generator.

Abstract: A handle arrangement on a vacuum cleaner hose has an inner bushing non-rotatably attached to one end of the hose and is inserted in a handle tube and axially fixed therein such that it can rotate. Electrical leads are guided outwards from the hose and the inner bushing in a radial direction through a wall opening of the handle tube and into the cavity of a handle part. The handle part is firmly connected at both ends to the handle tube. The electrical leads are fixed so as to form a length reserve loop in the cavity. A receiving space is provided on the inner bushing, into which electrical leads from the length reserve loop are shifted when relative rotations take place between the hose and the handle tube. The possible rotation angle is delimited by stops according to the lead length available in the length reserve loop.

Abstract: An anti-kink device for hoses with an external corrugated structure, in particular for vacuum cleaner hoses, such hoses comprising at least one external groove-like channel which runs in a helical manner. The anti-kink device is formed by a wire coil made from spring steel which is screwed into the groove-like channel from one hose end and is fixed to the hose end. This anti-kink device is applied over the entire hose length or only partially at points of the hose which are at risk of kinking.

Abstract: A kink protector for a line which is led outwardly through a wall opening in a connecting sleeve of a hose or a pipe. The kink protector has a mounting cap which encloses the line, and a support helix which is integral with the cap and surrounds the line and which is resilient in bending. An outlet stub is provided at the connecting sleeve and is connected with the wall opening and into which the mounting cap can be pushed with at least axial fixing of the line in mechanically positive and detenting manner for the line.