Patents by Inventor Georg Rueedi
Georg Rueedi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200325154Abstract: The invention relates to antibacterial compounds of formula I wherein U1 represents N or CH, U2 represents N or CH, U3 represents N or CH, it being understood that at most two of U1, U2, U3 can represent N at the same time; V1 represents N or CH, V2 represents N, CH or C(OH) and V3 represents N, CH or C(OH), it being understood that at most two of V1, V2 and V3 can represent N at the same time; the dotted line “” represents a bond or is absent; X represents CH or N; and Q represents O or S. It further relates pharmaceutical compositions containing these compounds and the uses of these compounds in the manufacture of medicaments for the treatment of bacterial infections. These compounds are useful antimicrobial agents effective against a variety of human and veterinary pathogens including among others Gram-positive and Gram-negative aerobic and anaerobic bacteria.Type: ApplicationFiled: April 13, 2017Publication date: October 15, 2020Inventors: Sylvaine CREN, Georg RUEEDI, Cornelia ZUMBRUNN
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Patent number: 10633395Abstract: The invention relates to aryloxazolidinone compounds of formula I: wherein Y represents hydrogen or certain chemical groups. These compounds are useful antimicrobial agents effective against a variety of pathogens including inter alia Gram-negative aerobic and anaerobic bacteria.Type: GrantFiled: February 16, 2018Date of Patent: April 28, 2020Assignee: Idorsia Pharmaceuticals Ltd.Inventors: Daniel Ritz, Georg Rueedi, Cornelia Zumbrunn
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Publication number: 20190367532Abstract: The invention relates to aryloxazolidinone compounds of formula I: wherein Y represents hydrogen or certain chemical groups. These compounds are useful antimicrobial agents effective against a variety of pathogens including inter alia Gram-negative aerobic and anaerobic bacteria.Type: ApplicationFiled: February 16, 2018Publication date: December 5, 2019Inventors: Daniel RITZ, Georg RUEEDI, Cornelia ZUMBRUNN
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Patent number: 10441576Abstract: The invention relates to antibacterial compounds of formula I wherein M is one of the groups MA, MB and MC represented below and either R1 represents H and R2 represents a cleavable group as defined in the claims or R2 represents H and R1 represents a cleavable group as defined in the claims; and salts thereof.Type: GrantFiled: August 10, 2016Date of Patent: October 15, 2019Assignee: IDORSIA PHARMACEUTICALS LTD.Inventors: Stefan Diethelm, Philippe Panchaud, Georg Rueedi, Jean-Luc Specklin, Jean-Philippe Surivet
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Publication number: 20180235938Abstract: The invention relates to antibacterial compounds of formula I wherein M is one of the groups MA, MB and MC represented below and either R1 represents H and R2 represents a cleavable group as defined in the claims or R2 represents H and R1 represents a cleavable group as defined in the claims; and salts thereof.Type: ApplicationFiled: August 10, 2016Publication date: August 23, 2018Inventors: Stefan DIETHELM, Philippe PANCHAUD, Georg RUEEDI, Jean-Luc SPECKLIN, Jean-Philippe SURIVET
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Patent number: 9850256Abstract: The invention relates to antibacterial compounds of formula I wherein R1a, R2a, R2b, R3a, R3b, R4, R5, U1, U2, U3, U4, V1, V2, V3, V4, X and Q and n are as defined in the specification. It further relates pharmaceutical compositions containing these compounds and the uses of these compounds in the manufacture of medicaments for the treatment of bacterial infections. These compounds are useful antimicrobial agents effective against a variety of human and veterinary pathogens including among others Gram-positive and Gram-negative aerobic and anaerobic bacteria.Type: GrantFiled: October 14, 2015Date of Patent: December 26, 2017Assignee: IDORSIA PHARMACEUTICALS LTDInventors: Sylvaine Cren, Astrid Friedli, Georg Rueedi, Cornelia Zumbrunn
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Patent number: 9822114Abstract: The invention relates to compounds of formula I wherein is a bond or is absent, V is CH, CR6 or N; R0 is H or, if is a bond, may also be alkoxy; R1 is H or halogen; U is CH or N when is a bond, or, if is absent, U is CH2, NH or NR9; R2 is H, alkylcarbonyl or —CH2—R3; R3 is H, alkyl or hydroxyalkyl; R4 is H or, if n is not 0 and R5 is H, may also be OH; R5 is H, alkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, carboxy or alkoxycarbonyl; R6 is hydroxyalkyl, carboxy, alkoxycarbonyl or —(CH2)q—NR7R8, q being 1, 2 or 3 and each of R7 and R8 independently being H or alkyl or R7 and R8 forming with the N atom bearing them a ring; R9 is alkyl or hydroxyalkyl; A is —(CH2)p—, —CH2CH2CH(OH)— or —COCH2CH(OH)—; G is substituted phenyl or G1 or G2 wherein Q is O or S and X is CH or N; and Y1, Y2 and Y3 may each be CH or N; and n is 0 when A is —CH2CH2CH(OH)— or —COCH2CH(OH)—, and n is 0, 1 or 2 when A is —(CH2)p—, p being 1, 2, 3 or 4, with the proviso that the sum of n and p is then 2, 3 or 4; and to salts thereType: GrantFiled: April 21, 2016Date of Patent: November 21, 2017Assignee: IDORSIA PHARMACEUTICALS LTDInventors: Christian Hubschwerlen, Daniel Ritz, Georg Rueedi, Jean-Philippe Surivet, Cornelia Zumbrunn-Acklin
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Publication number: 20170305927Abstract: The invention relates to antibacterial compounds of formula I wherein R1a, R2a, R2b, R3a, R3b, R4, R5, Ul, U2, U3, U4, V1, V2, V3, V4, X and Q and n are as defined in the specification. It further relates pharmaceutical compositions containing these compounds and the uses of these compounds in the manufacture of medicaments for the treatment of bacterial infections. These compounds are useful antimicrobial agents effective against a variety of human and veterinary pathogens including among others Gram-positive and Gram-negative aerobic and anaerobic bacteria.Type: ApplicationFiled: October 14, 2015Publication date: October 26, 2017Inventors: Sylvaine CREN, Astrid FRIEDLI, Georg RUEEDI, Cornelia ZUMBRUNN
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Patent number: 9540399Abstract: The invention relates to antibacterial compounds of formula I wherein R1, U, V and A are as defined in the description, to pharmaceutical compositions containing them and uses of these compounds in the manufacture of medicaments for the treatment of bacterial infections.Type: GrantFiled: April 30, 2014Date of Patent: January 10, 2017Assignee: Actelion Pharmaceuticals Ltd.Inventors: Stephanie Enderlin-Paput, Christian Hubschwerlen, Georg Rueedi, Cornelia Zumbrunn
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Patent number: 9527867Abstract: The invention relates to antibacterial compounds of formula I and salts thereof and methods of treating bacterial infection using the compounds.Type: GrantFiled: April 15, 2014Date of Patent: December 27, 2016Assignee: Actelion Pharmaceuticals Ltd.Inventors: Sylvaine Cren, Astrid Friedli, Christian Hubschwerlen, Georg Rueedi, Cornelia Zumbrunn
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Patent number: 9505750Abstract: The invention relates to antibacterial compounds of formula I wherein one or two of U, V, W, and X represent N, the rest represent CH or, in the case of X, may also represent CRa wherein Ra is fluorine; R1 represents alkoxy, halogen or cyano; R2 represents H, CH2OH, CH2N3, CH2NH2, alkylcarbonylaminomethyl or triazol-1-ylmethyl; R3 represents H, or, when n is 1, R3 may also represent OH, NH2, NHCOR6 or triazol-1-yl; A represents CR4; K represents O, NH, OCH2, NHCO, NHCH2, CH2NH, CH2CH2, CH?CH, CHOHCHOH or CHR5; R4 represents H or together with R5 forms a bond, or also R4 can represent OH when K is not O, NH, OCH2 or NHCO; R5 represents OH or together with R4 forms a bond; R6 represents alkyl; m is 0 or 1 and n is 0 or 1; and G is as defined in the description; and to salts of such compounds.Type: GrantFiled: December 17, 2008Date of Patent: November 29, 2016Assignee: ACTELION PHARMACEUTICALS LTD.Inventors: Christian Hubschwerlen, Georg Rueedi, Jean-Philippe Surivet, Cornelia Zumbrunn Acklin
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Patent number: 9487516Abstract: The invention relates to antibacterial compounds of formula I wherein U represents CH or N; V represents CH or N, provided that at least one of U and V does not represent N; R represents H, halogen, methyl, methoxy, cyano or ethynyl; either W represents a phenyl group substituted in para position with (C1-C3)alkyl, (C1-C3)alkoxy or (C1-C3)thioalkoxy and optionally in meta position with halogen, or W is a group having one of the formulae W1 and W2 below wherein Q is O or S and X is CH or N; and salts of such compounds.Type: GrantFiled: January 8, 2014Date of Patent: November 8, 2016Assignee: Actelion Pharmaceuticals, Ltd.Inventors: Christian Hubschwerlen, Georg Rueedi, Cornelia Zumbrunn
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Publication number: 20160237088Abstract: The invention relates to compounds of formula I wherein “” is a bond or is absent, V is CH, CR6 or N; R0 is H or, if “” is a bond, may also be alkoxy; R1 is H or halogen; U is CH or N when “” is a bond, or, if “” is absent, U is CH2, NH or NRg; R2 is H, alkylcarbonyl or —CH2—R3; R3 is H, alkyl or hydroxyalkyl; R4 is H or, if n is not 0 and R5 is H, may also be OH; R5 is H, alkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, carboxy or alkoxycarbonyl; R6 is hydroxyalkyl, carboxy, alkoxycarbonyl or —(CH2)q—NR7R8, q being 1, 2 or 3 and each of R7 and R8 independently being H or alkyl or R7 and R8 forming with the N atom bearing them a ring; R9 is alkyl or hydroxyalkyl; A is —(CH2)p—, —CH2CH2CH(OH)— or —COCH2CH(OH)—; G is substituted phenyl or G1 or G2 wherein Q is O or S and X is CH or N; and Y1, Y2 and Y3 may each be CH or N; and n is 0 when A is —CH2CH2CH(OH)— or —COCH2CH(OH)—, and n is 0, 1 or 2 when A is —(CH2)p—, p being 1, 2, 3 or 4, with the proviso that the sum of n and p is then 2, 3 or 4; and to saltType: ApplicationFiled: April 21, 2016Publication date: August 18, 2016Inventors: Christian HUBSCHWERLEN, Daniel RITZ, Georg RUEEDI, Jean-Philippe SURIVET, Cornelia ZUMBRUNN-ACKLIN
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Patent number: 9346804Abstract: The present invention relates to antibacterial compounds of formula (I) wherein “----” is a bond or is absent, V is CH, CR6 or N; R0 is H or, if “----” is a bond, may also be alkoxy; R1 is cyano, alkyl, or ethynyl; U is CH or N when “----” is a bond, or, if “----” is absent, U is CH2, NH or NH9; R2 is H, alkylcarbonyl or CH2—R3; R3 is H, alkyl or hydroxyalkyl; R4 is H or, if n is not 0 and R5 is H, may also be OH; R5 is H, alkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, carboxy or alkoxycarbonyl; R6 is hydroxyalkyl, carboxy, alkoxycarbonyl or —(CH2)q—NR7R8, q being 1, 2 or 3 and each of R7 and R8 independently being H or alkyl or R7 and R8 forming with the N atom bearing them a ring; R9 is alkyl or hydroxyalkyl; A is —(CH2)p—, —CH2CH2CH(OH)— or —COCH2CH(OH)—; G is substituted phenyl or G1 or G2, wherein Q is O or S and X is CH or N; and Y1, Y2 and Y3 may each be CH or N; and n is 0 when A is —CH2CH2CH(OH)— or —COCH2CH(OH)—, and n is 0, 1 or 2 when A is —(CH2)p—, p being 1, 2, 3 or 4, with the proviso that the sType: GrantFiled: December 4, 2013Date of Patent: May 24, 2016Assignee: Actelion Pharmaceuticals Ltd.Inventors: Christian Hubschwerlen, Daniel Ritz, Georg Rueedi, Jean-Philippe Surivet, Cornelia Zumbrunn-Acklin
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Publication number: 20160090383Abstract: The invention relates to antibacterial compounds of formula I wherein R, M and A are as defined in the description, to pharmaceutical compositions containing them and uses of these compounds in the manufacture of medicaments for the treatment of bacterial infections.Type: ApplicationFiled: May 7, 2014Publication date: March 31, 2016Inventors: Christian HUBSCHWERLEN, Verena KAEGI-EGGER, Georg RUEEDI, Cornelia ZUMBRUNN
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Publication number: 20160075722Abstract: The invention relates to antibacterial compounds of formula I (I) wherein R is H, cyano, alkoxy, cyanomethoxy, cycloalkylmethoxy, hydroxyalkoxy, alkoxyalkoxy, alkoxycarbonyl, 2-ethoxy-2-oxoethoxy, 2-(methylamino)-2-oxoethoxy, (1-cyanocyclobutyl)methoxy, 3-hydroxy-pyrrolidin-1-yl or 3,4-dihydroxycyclopentyl)methoxy; U1 is N or CR1, U2 is N or CR1, U3 is N or CR3 and U4 is N or CR1, it being understood that at most three of U1, U2, U3 and U4 can be N at the same time; V1 is N or CR5, V2 is N or CR6, V3 is N or CR7 and V4 is N or CH, it being understood that at most two of V1, V2, V3 and V4 can be N at the same time; R1 is H, cyano, hydroxy or alkoxy; R2 is H, hydroxy or alkoxy; R3 is H, cyano, hydroxy, alkoxy or carboxamido; R4 is H or alkoxy; R5 is H, hydroxy or halogen; R6 is H, hydroxy or halogen; R7 is H; the dotted line “______” represents a bond or is absent; W represents CH or N when the dotted line “______” is a bond, or W represents CH2 when the dotted line “______” is absent; X represents CH or N; andType: ApplicationFiled: April 15, 2014Publication date: March 17, 2016Inventors: Sylvaine CREN, Astrid FRIEDLI, Christian HUBSCHWERLEN, Georg RUEEDI, Cornelia ZUMBRUNN
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Publication number: 20160060276Abstract: The invention relates to antibacterial compounds of formula I wherein R1, U, V and A are as defined in the description, to pharmaceutical compositions containing them and uses of these compounds in the manufacture of medicaments for the treatment of bacterial infections.Type: ApplicationFiled: April 30, 2014Publication date: March 3, 2016Inventors: Stephanie ENDERLIN-PAPUT, Christian HUBSCHWERLEN, Georg RUEEDI, Cornelia ZUMBRUNN
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Publication number: 20150353547Abstract: The invention relates to antibacterial compounds of formula I wherein U represents CH or N; V represents CH or N, provided that at least one of U and V does not represent N; R represents H, halogen, methyl, methoxy, cyano or ethynyl; either W represents a phenyl group substituted in para position with (C1-C3)alkyl, (C1-C3)alkoxy or (C1-C3)thioalkoxy and optionally in meta position with halogen, or W is a group having one of the formulae W1 and W2 below wherein Q is O or S and X is CH or N; and salts of such compounds.Type: ApplicationFiled: January 8, 2014Publication date: December 10, 2015Inventors: Christian HUBSCHWERLEN, Georg RUEEDI, Cornelia ZUMBRUNN
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Patent number: 9079922Abstract: The invention relates to antibacterial compounds of formula I wherein R1a represents H or carboxy and R1b represents H, or R1a and R1b represent together either the group *—C(O)—NH—S—# or the group *—C(OH)?N—S—# wherein “*” represents the point of attachment of R1a and “#” represents the point of attachment of R1b; R2 represents H, (C1-C3)alkyl, hydroxy-(C1-C3)alkyl, benzyl or (C3-C5)cycloalkyl; R3 represents H or halogen; U represents N or CR4; wherein R4 is H or (C1-C3)alkoxy; A represents CH, B represents NH and m represents 1 or 2 and n represents 1 or 2; or A represents N, B is absent, m represents 2 and n represents 2; Y represents CH or N; and Q represents O or S; and salts of such compounds.Type: GrantFiled: November 7, 2012Date of Patent: July 14, 2015Assignee: Actelion Pharmaceuticals LtdInventors: Christian Hubschwerlen, Georg Rueedi, Jean-Philippe Surivet, Cornelia Zumbrunn Acklin
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Patent number: 9029368Abstract: The invention relates to antibacterial compounds of formula I wherein G and K are as defined in the description; and salts of such compounds.Type: GrantFiled: November 29, 2012Date of Patent: May 12, 2015Assignee: Actelion Pharmaceuticals Ltd.Inventors: Christian Hubschwerlen, Georg Rueedi, Jean-Philippe Surivet, Cornelia Zumbrunn Acklin