Abstract: The present invention relates to bispecific anti-CCL2 antibodies binding to two different epitopes on human CCL2, pharmaceutical compositions thereof, their manufacture, and use as medicaments for the treatment of cancers, inflammatory, autoimmune and ophthalmologic diseases.

Abstract: A torsional moment acting on a component in a drive train of an aircraft may be determined using at least one sensor, where the determined torsional moment is used for adjusting at least one adjustable damping element located in or on the component and/or for regulating a torsional stiffness in the torque-conducting component. As a result, the torsional load in the component may be reduced.

Abstract: The present invention relates to bispecific anti-CCL2 antibodies binding to two different epitopes on human CCL2, pharmaceutical compositions thereof, their manufacture, and use as medicaments for the treatment of cancers, inflammatory, autoimmune and ophthalmologic diseases.

Abstract: A spline connection having a hub with a toothing profile on the inner circumference, an axle journal having a toothing profile on an outer circumferential portion, a shoulder for axial support and/or abutment against the hub, and a tensioning device for axially bracing the axle journal with the hub. The hub has a constant toothing profile and the axle journal has a first portion and a second portion with different toothing profiles. The first portion is arranged on the insertion side to be further away from the shoulder than the second portion and has a constant toothing profile with play with respect to the toothing profile of the hub. The second portion is arranged on the shoulder side and has a toothing profile which has reduced tooth spaces compared with the first portion and which is play-free with respect to the toothing profile of the hub.

Abstract: A spline connection having a hub with a toothing profile on the inner circumference, an axle journal having a toothing profile on an outer circumferential portion, a shoulder for axial support and/or abutment against the hub, and a tensioning device for axially bracing the axle journal with the hub. The hub has a constant toothing profile and the axle journal has a first portion and a second portion with different toothing profiles. The first portion is arranged on the insertion side to be further away from the shoulder than the second portion and has a constant toothing profile with play with respect to the toothing profile of the hub. The second portion is arranged on the shoulder side and has a toothing profile which has reduced tooth spaces compared with the first portion and which is play-free with respect to the toothing profile of the hub.

Abstract: A focusing device for an optical system that has a carrier and an objective arranged thereat comprises a first guide section that is configured for fastening to the carrier or is designed in one piece therewith, a second guide section that forms a holder for the objective, at least one spring element that forms an elastic connection of the first guide section to the second guide section, and an actuator for adjusting the second guide section in and against an adjustment direction with respect to the first guide section, wherein the spring element is areal at least regionally. The spring element has at has one stiffening zone in which a first surface section of the spring element is bent over along a bending edge with respect to a second surface section of the spring element.

Abstract: A focusing device for an optical system that has a carrier and an objective arranged thereat comprises a first guide section that is configured for fastening to the carrier or is designed in one piece therewith, a second guide section that forms a holder for the objective, at least one spring element that forms an elastic connection of the first guide section to the second guide section, and an actuator for adjusting the second guide section in and against an adjustment direction with respect to the first guide section, wherein the spring element is areal at least regionally. The spring element has at has one stiffening zone in which a first surface section of the spring element is bent over along a bending edge with respect to a second surface section of the spring element.

Abstract: Focus-adjustable optics (28) for an optoelectronic sensor (10), the focus-adjustable optics (28) having at least one optical element (14), an actuator (34) for moving the optical element (14), and a swivel arm (30), with the optical element (14) being arranged on the swivel arm (30) and the actuator (34) engaging the swivel arm (34) for moving the swivel arm (30) with the optical element (14) relative to a bearing point (32), wherein the swivel arm (30) is configured as a two-sided lever having a first lever arm on one side of the bearing point (32) and a second lever arm on another side of the bearing point (32), the optical element (14) being arranged on the first lever arm and the actuator (34) being arranged at the second lever arm, and wherein the swivel arm (30) is balanced.

Abstract: An optoelectronic sensor is provided comprising a focus-adjustable optics, wherein the sensor has a movable carrier element having the optics and has a fixed-position holding element as well as a focus adjustment unit that comprises a moving coil and a magnetic unit to vary the position of the movable carrier element with respect to the holding element and thus the setting of a focal position. The moving coil is here configured as a circuit board coil.

Abstract: An optical code reader (10) is provided that has a light transmitter (12) having a transmission optics (14) for transmitting a reading beam (16) in a reading region (18); a focus adjustment unit (28) for focusing the reading beam (16) in a distance range; a light receiver (24) for generating a received signal from the reading beam (20) reflected in the reading region (18); and an evaluation unit (26) to read code information from the received signal. In this respect, the focus adjustment unit (28) has a pivot arm (30) that holds the transmission optics (14) at a different distance from the light transmitter (12) in dependence on the pivot position of the pivot arm (30) and that has a moving coil unit (34) to pivot the pivot arm (30).

Abstract: The invention relates to a molding compound, comprising the following components: a) 60 to 96% by weight polyaryletherketone, b) 2 to 25% by weight hexagonal bornite, and c) 2 to 25% by weight talcum, wherein the sum of the parts by weight of components a), b), and c) is 100. Said compounds can be used to produce a film having a thickness of 5 to 1200 ?m, which is suitable for producing dimensionally stable circuit boards.

Abstract: The present invention relates to a novel method for identifying specific marker sequences for diagnosis of prostate cancer and/or for prognosis in prostate cancer, and to the use of the specific marker sequences identified with the aid of this method.

Abstract: A polyamide molding composition which can be used for production of a printable or printed item contains a) at most 90 parts by weight of a polyamide obtained from a lactam or from an amino carboxylic acid having at least 10 carbon atoms; and b) from 10 to 100 parts by weight of PA1010, wherein a total of components a) and b) is 100 parts by weight.

Abstract: The invention relates to a molding compound, comprising the following components: a) 60 to 96% by weight polyaryletherketone, b) 2 to 25% by weight hexagonal bornite, and c) 2 to 25% by weight talcum, wherein the sum of the parts by weight of components a), b), and c) is 100. Said compounds can be used to produce a film having a thickness of 5 to 1200 ?m, which is suitable for producing dimensionally stable circuit boards.

Abstract: A polyamide molding composition which can be used for production of a printable or printed item contains a) at most 90 parts by weight of a polyamide obtained from a lactam or from an amino carboxylic acid having at least 10 carbon atoms; and b) from 10 to 100 parts by weight of PA1010, wherein a total of components a) and b) is 100 parts by weight.

Abstract: A polyamide molding composition which can be used for production of a printable or printed item contains a) at most 90 parts by weight of a polyamide obtained from a lactam or from an amino carboxylic acid having at least 10 carbon atoms; and b) from 10 to 100 parts by weight of PA1010, wherein a total of components a) and b) is 100 parts by weight.

Abstract: The invention concerns a corrector device for a timepiece for correcting a piece of information provided by an indicator mechanism (46), the timepiece comprising a case (1) delimiting a volume (8), the device being characterised in that it includes a control lever (14) located outside the volume (8) of the case (1) and able to be actuated by a user, and an actuating lever (16) located inside the volume (8) of the case (1) and cooperating with the indicator mechanism (46) providing the information to be corrected, the control lever (14) and the actuating lever (16) being connected to each other by a stem (20).

Abstract: Organic compounds having active hydrogen are separated from heterogeneous mixtures of organic compounds, such as tar, which also contain organic compounds which do not have active hydrogen. The method involves preferential conversion of the active hydrogen compounds to soluble compounds by reaction with a reagent which is an alkene oxide or ethyleneimine, introducing a solvent for the soluble compounds whereby two phases are formed, and then separating the phases.