Patents by Inventor Georg Seelig

Georg Seelig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210388415
    Abstract: Kits and methods for enriching target nucleic acid sequences, such as nucleic acid molecules including the target nucleic acid sequence, and kits and methods for depleting target nucleic acid sequences, such as nucleic acid molecules including the target nucleic acid sequences. In an embodiment, the methods for enriching target nucleic acid sequences include selectively degrading single-stranded sample nucleic acid molecules, such as those that do not include the target nucleic acid sequences. In an embodiment, the methods for depleting target nucleic acid sequences include selectively degrading double-stranded sample nucleic acid molecules, such as those including the target nucleic acid sequence.
    Type: Application
    Filed: October 24, 2019
    Publication date: December 16, 2021
    Applicant: University of Washington
    Inventors: Alexander B. Rosenberg, Charles Roco, Georg Seelig
  • Patent number: 11168355
    Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: November 9, 2021
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
  • Patent number: 11164661
    Abstract: In some embodiments, systems and methods for storing and/or retrieving digital information in a nucleic acid library are provided. In some embodiments, an integrated system comprising a nucleic acid synthesis device, a nucleic acid sequencing device, a computing device, and a nucleic acid library is provided. In some embodiments, a write request that associates a value with a key is received by the system, the system synthesizes nucleic acid molecules associated with the request, and stores the nucleic acid molecules in the nucleic acid library. In some embodiments, a read request for a key is received by the system, and the system sequences nucleic acid molecules from the nucleic acid library that are associated with the key.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: November 2, 2021
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Luis Henrique Ceze, Georg Seelig
  • Publication number: 20210310046
    Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
    Type: Application
    Filed: December 15, 2020
    Publication date: October 7, 2021
    Applicant: University of Washington
    Inventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
  • Publication number: 20210189463
    Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
    Type: Application
    Filed: February 25, 2021
    Publication date: June 24, 2021
    Applicant: University of Washington
    Inventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
  • Patent number: 10900065
    Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: January 26, 2021
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
  • Publication number: 20200291389
    Abstract: Methods of labeling or barcoding molecules within one or more portions of a plurality of cells are provided. Kits and systems for labeling or barcoding molecules within one or more portions of a plurality of cells are also provided. The methods, kits, and systems may utilize photo-controlled adapter sequences, nucleic acids tags, and/or linkers.
    Type: Application
    Filed: March 17, 2020
    Publication date: September 17, 2020
    Inventors: Georg Seelig, Anna Kuchina, Alexander B. Rosenberg
  • Publication number: 20200263234
    Abstract: Methods of uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs and/or cDNAs.
    Type: Application
    Filed: September 21, 2018
    Publication date: August 20, 2020
    Inventors: Georg SEELIG, Alexander B. ROSENBERG, Charles ROCO
  • Patent number: 10689684
    Abstract: This disclosure describes techniques to improve the sequencing of polynucleotides by decreasing the likelihood of errors occurring during a sequencing calibration process. In implementations, regions of polynucleotides that are used for the calibration process can be modified to reduce a number of polynucleotides that have a same nucleotide at one or more positions of the calibration regions. In some cases, the calibration regions can be modified by adding a sequence to the polynucleotides that replaces the original calibration regions. Also, the calibration regions can be modified by rearranging the nucleotides at the different positions of the calibration regions. Additionally, the calibration regions can be modified by adding sequences of varying length to the polynucleotides being sequenced to produce polynucleotides having varying length with different calibration regions.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: June 23, 2020
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Yuan-Jyue Chen, Karin Strauss, Luis H. Ceze, Lee Organick, Randolph Lopez, Georg Seelig
  • Patent number: 10633648
    Abstract: Methods of labeling or barcoding molecules within one or more portions of a plurality of cells are provided. Kits and systems for labeling or barcoding molecules within one or more portions of a plurality of cells are also provided. The methods, kits, and systems may utilize photo-controlled adapter sequences, nucleic acids tags, and/or linkers.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: April 28, 2020
    Assignee: University of Washington
    Inventors: Georg Seelig, Anna Kuchina, Alexander B. Rosenberg
  • Publication number: 20180326797
    Abstract: A braceable run-flat insert for a vehicle wheel has subelements forming a circular ring. The subelements are connected in an articulated manner or braced by a clamping system. To prevent the ingress of dirt, the cross section of the subelements forms a T shape on the tire side. The crossbar of the T is a running surface for the tire when there is a tire defect. The cross section of the subelements form an approximate T shape on the rim side. Two lateral end points fit on the rim base and rest on the latter in the fitted state. The tire-side T and the rim-side T are connected by a radially running web. The lateral end points of the crossbar of the rim-side T-shaped configuration can be displaced toward one another against a restoring force by an elastic subregion between the two end points of the crossbar.
    Type: Application
    Filed: February 2, 2016
    Publication date: November 15, 2018
    Inventor: Hans-Georg SEELIG
  • Publication number: 20180230509
    Abstract: This disclosure describes techniques to improve the sequencing of polynucleotides by decreasing the likelihood of errors occurring during a sequencing calibration process. In implementations, regions of polynucleotides that are used for the calibration process can be modified to reduce a number of polynucleotides that have a same nucleotide at one or more positions of the calibration regions. In some cases, the calibration regions can be modified by adding a sequence to the polynucleotides that replaces the original calibration regions. Also, the calibration regions can be modified by rearranging the nucleotides at the different positions of the calibration regions. Additionally, the calibration regions can be modified by adding sequences of varying length to the polynucleotides being sequenced to produce polynucleotides having varying length with different calibration regions.
    Type: Application
    Filed: February 14, 2017
    Publication date: August 16, 2018
    Inventors: Yuan-Jyue Chen, Karin Strauss, Luis H. Ceze, Lee Organick, Randolph Lopez, Georg Seelig
  • Publication number: 20180068060
    Abstract: In some embodiments, systems and methods for storing and/or retrieving digital information in a nucleic acid library are provided. In some embodiments, an integrated system comprising a nucleic acid synthesis device, a nucleic acid sequencing device, a computing device, and a nucleic acid library is provided. In some embodiments, a write request that associates a value with a key is received by the system, the system synthesizes nucleic acid molecules associated with the request, and stores the nucleic acid molecules in the nucleic acid library. In some embodiments, a read request for a key is received by the system, and the system sequences nucleic acid molecules from the nucleic acid library that are associated with the key.
    Type: Application
    Filed: April 8, 2016
    Publication date: March 8, 2018
    Applicant: University of Washington
    Inventors: Luis Henrique Ceze, Georg Seelig
  • Publication number: 20170233722
    Abstract: Methods of labeling or barcoding molecules within one or more portions of a plurality of cells are provided. Kits and systems for labeling or barcoding molecules within one or more portions of a plurality of cells are also provided. The methods, kits, and systems may utilize photo-controlled adapter sequences, nucleic acids tags, and/or linkers.
    Type: Application
    Filed: February 10, 2017
    Publication date: August 17, 2017
    Applicant: University of Washington
    Inventors: Georg Seelig, Anna Kuchina, Alexander B. Rosenberg
  • Publication number: 20160138086
    Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
    Type: Application
    Filed: November 13, 2015
    Publication date: May 19, 2016
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
  • Publication number: 20140302486
    Abstract: A detection probe for detecting single base mutations or alterations in a double stranded target nucleic acid molecule is provided. In some aspects, the detection probe may include a double-stranded probe nucleic acid molecule having a first end and a second end; at least one probe initiation toehold at the first end; at least one substance capable of emitting a detectable signal at the second end; and optionally, at least one dissociation toehold at the second end. The detection probe is designed to hybridize with a double stranded target nucleic acid in a reaction which proceeds at approximate thermodynamic equilibrium (?G?0) when no single base mutations or alterations are present in the double stranded target nucleic acid molecule. The probe may be used in detection systems and methods to identifying the presence or absence of one or more single base mutations or alterations in a double-stranded nucleic acid target molecule.
    Type: Application
    Filed: December 23, 2013
    Publication date: October 9, 2014
    Inventors: Georg Seelig, Xi Chen, David Yu Zhang
  • Publication number: 20130071839
    Abstract: In some embodiments, a strand displacement system is provided. Such a system may include a first nucleic acid catalyst molecule; a nucleic acid gate molecule, wherein the first nucleic acid catalyst molecule binds the nucleic acid gate molecule forming a nucleic acid gate-catalyst complex and releases an output molecule; and a nucleic acid sink molecule. The nucleic acid sink molecule sequesters a putative second nucleic acid catalyst, wherein the second nucleic acid catalyst differs from the first nucleic acid catalyst molecule by at least one nucleotide. In some aspects, the first nucleic acid catalyst may include a biomarker of interest or a nucleic acid aptamer which binds an amino acid-based biomarker of interest.
    Type: Application
    Filed: September 4, 2012
    Publication date: March 21, 2013
    Inventors: Georg Seelig, Barry Lutz
  • Patent number: 7745594
    Abstract: This invention relates to nucleic acid-based logic gates. The invention further relates to circuits comprising nucleic acid-based logic gates and methods of performing operations with the gates and circuits provided herein.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: June 29, 2010
    Assignee: California Institute of Technology
    Inventors: Georg Seelig, David Soloveichik, Erik Winfree, David Zhang
  • Publication number: 20070072215
    Abstract: This invention relates to nucleic acid-based logic gates. The invention further relates to circuits comprising nucleic acid-based logic gates and methods of performing operations with the gates and circuits provided herein.
    Type: Application
    Filed: July 21, 2006
    Publication date: March 29, 2007
    Applicant: The California Institute of Technology
    Inventors: Georg Seelig, David Soloveichik, Erik Winfree, David Zhang