Abstract: The invention relates to proteases that exhibit proteolytic activity and comprise an amino acid sequence that is at least 70% and increasingly preferably at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, and 98% identical to the amino acid sequence indicated in SEQ ID NO:1 over its entire length, wherein the protease comprises, based on the numbering according to SEQ ID NO:1, at least one amino acid substitution selected from the group consisting of N97E, R99E, R99I, R99N, R99V, R99T, D127E and M211C in at least one of the positions that correspond to positions 97.3 99, 127 and 211. Such proteases are suitable for use in washing and cleaning agents, in particular liquid textile washing agents, and have improved cleaning performance in comparison with a reference protease.

Abstract: The invention relates to proteases that exhibits proteolytic activity and comprises an amino acid sequence which, over its entire length, is at least 70% and increasingly preferably at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5% and 98% identical to the amino acid sequence specified in SEQ ID NO.

Abstract: The invention relates to a method for determining catalophores including the steps of creating a point cloud database for target protein structures; creating a query point cloud; and searching said database with said query to thereby identify one or more catalophores.

Abstract: The invention relates to a method for determining catalophores including the steps of creating a point cloud database for target protein structures; creating a query point cloud; and searching said database with said query to thereby identify one or more catalophores.