Patents by Inventor Georg T. Wondrak

Georg T. Wondrak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR DELIVERING PHARMACEUTICAL AGENTS
    Publication number: 20240033233
    Abstract: Provided herein are compositions and methods for delivering pharmaceutical agents. In particular, provided herein are topical formulations of resatorvid for use in treating and preventing skin pathologies.
    Type: Application
    Filed: July 30, 2021
    Publication date: February 1, 2024
    Inventors: Heidi Mansour, Victor Ruiz, Sally E. Dickinson, Clara N. Curiel, Hsiao-Hui Chow, Georg T. Wondrak
  • Compositions and methods for treating and preventing lung injury
    Patent number: 10300036
    Abstract: Provided herein are compositions and methods for treating and preventing lung injury (e.g. ventilation induced lung injury). In particular, the invention relates to compositions and methods for treating and preventing airway disease by activating the NRF2 pathway.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: May 28, 2019
    Assignee: ARIZONA BOARD OF REGENTS on behalf of THE UNIVERSITY OF ARIZONA
    Inventors: Donna D. Zhang, Georg T. Wondrak, Joe G. N. Garcia, Ting Wang
  • COMPOSITIONS AND METHODS FOR TREATMENT, AMELIORATION, AND PREVENTION OF DIABETES-RELATED SKIN ULCERS
    Publication number: 20180344680
    Abstract: Compositions and methods are provided for treating, ameliorating, and preventing diabetes-related skin ulcers in a mammalian subject comprising administering to the subject an effective amount of an NRF2 activating agent.
    Type: Application
    Filed: December 7, 2016
    Publication date: December 6, 2018
    Inventors: Donna D. Zhang, Georg T. Wondrak
  • COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING LUNG INJURY
    Publication number: 20180280338
    Abstract: Provided herein are compositions and methods for treating and preventing lung injury (e.g. ventilation induced lung injury). In particular, the invention relates to compositions and methods for treating and preventing airway disease by activating the NRF2 pathway.
    Type: Application
    Filed: October 5, 2016
    Publication date: October 4, 2018
    Applicant: THE ARIZONA BOARD OF REGENTS on behalf of THE UNIVERSITY OF ARIZONA
    Inventors: Donna D. Zhang, Georg T. Wondrak, Joe G.N. Garcia, Ting Wang
  • ACTIVATORS OF NRF2-DEPENDENT PHOTOPROTECTION AND RELATED USES THEREOF
    Publication number: 20180243190
    Abstract: Provided herein are methods for preventing conditions related to UV-radiation exposure in subjects at risk for exposure to UV-radiation. In particular, the invention relates to compositions comprising specific formulations of dietary carotenoids (e.g., bixin) which function as activators of NRF2 pathway related activity, and related methods for the protection of mammalian skin against UV-radiation.
    Type: Application
    Filed: August 17, 2016
    Publication date: August 30, 2018
    Inventors: Georg T. WONDRAK, Donna D. ZHANG
  • Methods for modulating phototoxicity
    Patent number: 7226937
    Abstract: The invention relates to methods for modulating photodamage via the use of collagen derived molecules which either enhance or inhibit damage caused by ultraviolet light.
    Type: Grant
    Filed: September 13, 2005
    Date of Patent: June 5, 2007
    Assignee: Board of Regents on Behalf of the University of Arizona
    Inventors: Georg T. Wondrak, Michael J. Roberts, Moonsun Kim, Myron K. Jacobson, Elaine L. Jacobson
  • Method for inducing cell death with carbonyl scavengers
    Patent number: 7217739
    Abstract: Carbonyl scavengers, which have been recognized for their ability to react with reactive carbonyl species, have been implicated as agents that can accelerate or induce the death of abnormal cells without having a parallel effect on normal cells. As such, they are useful therapeutic agents in cases where the acceleration or induction of cell death is desirable, such as in cells where the normal apoptotic pathways have been disrupted and where hyperproliferative cell growth occurs.
    Type: Grant
    Filed: March 1, 2005
    Date of Patent: May 15, 2007
    Assignee: Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Georg T. Wondrak, Myron K. Jacobson, Elaine L. Jacobson
  • Methods for modulating phototoxicity
    Patent number: 6992071
    Abstract: The invention relates to methods for modulating photodamage via the use of collagen derived molecules which either enhance or inhibit damage caused by ultraviolet light.
    Type: Grant
    Filed: April 17, 2003
    Date of Patent: January 31, 2006
    Assignee: Board of Regents on Behalf of the University of Arizona
    Inventors: Georg T. Wondrak, Michael J. Roberts, Moonsun Kim, Myron K. Jacobson, Elaine L. Jacobson
  • Method for identifying regulators of protein-advanced glycation end product (protein-AGE) formation
    Patent number: 6716635
    Abstract: The invention relates to methods for identifying compounds which affect cellular stress. In particular, the method relates to identifying compounds which inhibit protein advanced glycation end product formation, where the compounds are carbonyl scavengers which inhibit the formation. The assay involves combing the substance of interest with histone H1 and ADP-ribose, and then measuring fluorescence and protein cross linking. Various inhibitors of protein AGE glycation have been identified, using this assay.
    Type: Grant
    Filed: April 16, 2001
    Date of Patent: April 6, 2004
    Assignee: University of Kentucky Research Foundation
    Inventors: Elaine L. Jacobson, Myron K. Jacobson, Georg T. Wondrak
  • Methods for modulating phototoxicity
    Publication number: 20030223941
    Abstract: The invention relates to methods for modulating photodamage via the use of collagen derived molecules which either enhance or inhibit damage caused by ultraviolet light.
    Type: Application
    Filed: April 17, 2003
    Publication date: December 4, 2003
    Inventors: Georg T. Wondrak, Michael J. Roberts, Moonsun Kim, Myron K. Jacobson, Elaine L. Jacobson
  • Method and use of alpha-amino-beta-mercapto-ethane derivatives as dicarbonyl scavengers for treatment of conditions resulting from protein, lipid, and DNA damage
    Publication number: 20020156134
    Abstract: Methods of inhibiting damage to proteins, lipids, and DNA by the use of penicillamines and other &agr;-amino-&bgr;,&bgr;-mercapto-&bgr;,&bgr;-dimethyl-ethane compounds as dicarbonyl scavengers is disclosed.
    Type: Application
    Filed: March 7, 2002
    Publication date: October 24, 2002
    Inventors: Elaine L. Jacobson, Myron K. Jacobson, Georg T. Wondrak, Daniel Cervantes Laurean
  • Method and use of &agr;-amino-&bgr;-mercapto-ethane derivatives as dicarbonyl scavengers for treatment of conditions resulting from protein, lipid, and DNA damage
    Patent number: 6417235
    Abstract: Methods of inhibiting damage to proteins, lipids, and DNA by the use of penicillamines and other &agr;-amino-&bgr;,&bgr;-mercapto-&bgr;,&bgr;-dimethyl-ethane compounds as dicarbonyl scavengers is disclosed.
    Type: Grant
    Filed: April 16, 2001
    Date of Patent: July 9, 2002
    Assignee: University of Kentucky Research Foundation
    Inventors: Elaine L. Jacobson, Myron K. Jacobson, Georg T. Wondrak, Daniel Cervantes Laurean
  • Method for identifying regulators of protein-advanced glycation end product (protein-AGE) formation
    Publication number: 20020037496
    Abstract: The invention relates to methods for identifying compounds which affect cellular stress. In particular, the method relates to identifying compounds which inhibit protein advanced glycation end product formation, where the compounds are carbonyl scavengers which inhibit the formation. The assay involves combing the substance of interest with histone H1 and ADP-ribose, and then measuring fluorescence and protein cross linking. Various inhibitors ofprotein AGE glycation have been identified, using this assay.
    Type: Application
    Filed: April 16, 2001
    Publication date: March 28, 2002
    Inventors: Elaine L. Jacobson, Myron K. Jacobson, Georg T. Wondrak
  • Method and use of penicillamines and other alpha-amino-beta,beta-mercapto-beta,beta-dimethyl-ethane derivatives as dicarbonyl scavengers for treatment of conditions resulting from protein, lipid, and DNA damage
    Publication number: 20010051658
    Abstract: Methods of inhibiting damage to proteins, lipids, and DNA by the use of penicillamines and other &agr;-amino-&bgr;,&bgr;-mercapto-&bgr;,&bgr;-dimethyl-ethane compounds as dicarbonyl scavengers is disclosed.
    Type: Application
    Filed: April 16, 2001
    Publication date: December 13, 2001
    Inventors: Elaine L. Jacobson, Myron K. Jacobson, Georg T. Wondrak, Daniel Cervantes Laurean