Patents by Inventor Georg Widera

Georg Widera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7699801
    Abstract: Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for inducing an enhanced immune response against a selected antigen.
    Type: Grant
    Filed: May 22, 2007
    Date of Patent: April 20, 2010
    Assignee: Powderject Vaccines, Inc.
    Inventors: Joel R. Haynes, Georg Widera, James T. Fuller, Timothy Shipley, Deborah Fuller, Mary Wu
  • Patent number: 7570992
    Abstract: In vivo methods are provided for using an electric field to delivery therapeutic treatment to a subject while reducing inducement of histopathological change in the target muscle tissue, such as is associated with induction or amplification of an immune response caused by the pulsed electric field. Therapeutic agents can be delivered nto cells of muscle for local and systemic treatments with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Grant
    Filed: January 13, 2004
    Date of Patent: August 4, 2009
    Assignee: Genetronics, Inc.
    Inventors: Edward Nolan, Dietmar P. Rabussay, Georg Widera, Lei Zhang
  • Publication number: 20090017527
    Abstract: Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for inducing an enhanced immune response against a selected antigen.
    Type: Application
    Filed: May 22, 2007
    Publication date: January 15, 2009
    Inventors: Joel R. HAYNES, Georg Widera, James T. Fuller, Timothy Shipley, Deborah Fuller, Mary Wu
  • Patent number: 7223739
    Abstract: Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for inducing an enhanced immune response against a selected antigen.
    Type: Grant
    Filed: November 3, 1999
    Date of Patent: May 29, 2007
    Assignee: Powderject Vaccines, Inc.
    Inventors: Joel R. Haynes, Georg Widera, James T. Fuller, Timothy Shipley, Deborah Fuller, Mary Wu
  • Publication number: 20060036209
    Abstract: A system and method for transdermally delivering a biologically active agent comprising one or more electrodes having stratum corneum-piercing projections and a circuit that delivers an electrical signal to the electrodes to electroporate a cell membrane. Preferably, the system is configured to generate homogeneous electrical fields and, more preferably, to generate spherically or semispherically symmetrical electric fields. Methods of the invention include applying a first electric signal to facilitate transdermal transport of the agent and applying a second electric signal to facilitate intracellular transport of the agent.
    Type: Application
    Filed: November 1, 2004
    Publication date: February 16, 2006
    Inventors: Janardhanan Subramony, Georg Widera, Joseph Phipps, Michel Cormier
  • Publication number: 20050123565
    Abstract: A system and method for transdermally delivering a vaccine to a patient including an iontophoresis delivery device having a donor electrode, a counter electrode, and electric circuitry for supplying iontophoresis energy to the electrodes, and a non-electroactive microprojection member having a plurality of stratum corneum-piercing microprojections extending therefrom. The vaccine can be contained in a hydrogel formulation in an agent reservoir disposed proximate the donor electrode, in a biocompatible coating that is disposed on the microprojections or in both.
    Type: Application
    Filed: October 21, 2004
    Publication date: June 9, 2005
    Inventors: Janardhanan Subramony, Joseph Phipps, Michel Cormier, Georg Widera
  • Publication number: 20050112135
    Abstract: An apparatus and method for transdermally delivering a vaccine comprising a delivery system having (i) a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers and (ii) an ultrasonic device. In one embodiment, the vaccine is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having a vaccine-containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the vaccine is contained in both the coating and the hydrogel formulation.
    Type: Application
    Filed: October 21, 2004
    Publication date: May 26, 2005
    Inventors: Michel Cormier, WeiQi Lin, Georg Widera
  • Publication number: 20050090009
    Abstract: The present invention provides methods and compositions for stabilizing dried nucleic acids with carbohydrates such as non-reducing sugars, polysaccharides, and reducing sugars. Preferably, the stabilized nucleic acids are coated on a microprojection member for transdermal delivery. The invention further provides compositions and methods that involve the use of DNase inhibitors to stabilize dried nucleic acids delivered directly into bodily tissues.
    Type: Application
    Filed: October 21, 2004
    Publication date: April 28, 2005
    Inventors: Michel Cormier, Georg Widera, Mahmoud Ameri
  • Publication number: 20050054594
    Abstract: Methods are provided for enhancing an immune response induced by administration of a DNA vaccine. In the invention methods a DNA vaccine encoding an antigen and non-chemically associated adjuvant particles are injected into muscle, dermal or mucosal tissue of a subject at substantially the same time and the tissue is subjected to a pulsed electric field of sufficient strength to result in the DNA vaccine entering cells of the target tissue. The immune response to the antigen is enhanced as compared to when the DNA vaccine is administered alone or in combination with either of the electric pulses or the adjuvant particles without the other.
    Type: Application
    Filed: December 16, 2002
    Publication date: March 10, 2005
    Inventors: Lei Zhang, Georg Widera, Dietmar Rabussay
  • Publication number: 20040147964
    Abstract: In vivo methods are provided for using an electric field to delivery therapeutic treatment to a subject while reducing inducement of histopathological change in the target muscle tissue, such as is associated with induction or amplification of an immune response caused by the pulsed electric field. Therapeutic agents can be delivered nto cells of muscle for local and systemic treatments with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Application
    Filed: January 13, 2004
    Publication date: July 29, 2004
    Inventors: Edward Nolan, Dietmar P. Rabussay, Georg Widera, Lei Zhang
  • Publication number: 20040092860
    Abstract: The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Application
    Filed: June 9, 2003
    Publication date: May 13, 2004
    Inventors: Nagendu B. Dev, Gunter A. Hofmann, Edward Nolan, Dietmar P. Rabussay, Arnt Tonnessen, Georg Widera, Lei Zhang
  • Patent number: 6697669
    Abstract: The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: February 24, 2004
    Assignee: Genetronics, Inc.
    Inventors: Nagendu B. Dev, Gunter A. Hofmann, Edward Nolan, Dietmar P. Rabussay, Arnt Tonnessen, Georg Widera, Lei Zhang
  • Patent number: 6678556
    Abstract: In vivo methods are provided for using an electric field to delivery therapeutic treatment to a subject while reducing inducement of histopathological change in the target muscle tissue, such as is associated with induction or amplification of an immune response caused by the pulsed electric field. Therapeutic agents can be delivered nto cells of muscle for local and systemic treatments with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: January 13, 2004
    Assignee: Genetronics, Inc.
    Inventors: Edward Nolan, Dietmar P. Rabussay, Georg Widera, Lei Zhang
  • Patent number: 6654636
    Abstract: The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: November 25, 2003
    Assignee: Genetronics, Inc.
    Inventors: Nagendu B. Dev, Gunter A. Hofmann, Edward Nolan, Dietmar P. Rabussay, Arnt Tonnessen, Georg Widera, Lei Zhang
  • Publication number: 20020099323
    Abstract: The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Application
    Filed: July 13, 1999
    Publication date: July 25, 2002
    Inventors: NAGENDU B. DEV, GUNTER A. HOFMANN, EDWARD NOLAN, DIETMAR P. RABUSSAY, ARNT TONNESSEN, GEORG WIDERA, LEI ZHANG