Patents by Inventor Georg WUITSCHIK

Georg WUITSCHIK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESSES FOR THE PREPARATION OF SUBSTITUTED 1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-b]INDOLES
    Publication number: 20250388590
    Abstract: Provided herein are processes for the preparation of compounds useful in the treatment of cancer.
    Type: Application
    Filed: August 28, 2025
    Publication date: December 25, 2025
    Applicants: Hoffmann-La Roche Inc., Genentech, Inc.
    Inventors: HAIMING ZHANG, JIE XU, GEORG WUITSCHIK, REMY ANGELAUD, SEBASTIAN HEROLD, ALFRED STUTZ, TOBIAS BRUETSCH, JOHANNES BURKHARD
  • Processes for the preparation of substituted 1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indoles
    Patent number: 12448386
    Abstract: Provided herein are processes for the preparation of substituted 1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indoles using Wenker-Synthesis towards the synthesis of GDC-9545.
    Type: Grant
    Filed: December 5, 2023
    Date of Patent: October 21, 2025
    Assignees: Hoffmann-La Roche Inc., Genentech, Inc.
    Inventors: Haiming Zhang, Jie Xu, Georg Wuitschik, Remy Angelaud, Sebastian Herold, Alfred Stutz, Tobias Bruetsch, Johannes Burkhard
  • PROCESS
    Publication number: 20240182493
    Abstract: The present invention relates to a process for the preparation of 7-(4.7-diazaspiro[2.5]octan-7-vl)-2-(2.8-dimethylimidazo[1.2-b]pyridazin-6-vl)pyrido[1.2-a]pyrimidin-4-one derivatives useful as pharmaceutically active compounds.
    Type: Application
    Filed: September 15, 2023
    Publication date: June 6, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jean-Michel ADAM, Christophe Pfleger, Georg Wuitschik
  • PROCESSES FOR SYNTHESIS OF SUBSTITUTED INDOLE INTERMEDIATES FOR THE SYNTHESIS OF SERD COMPOUNDS
    Publication number: 20240174678
    Abstract: Provided herein are processes for the preparation of compounds useful in the treatment of cancer.
    Type: Application
    Filed: December 5, 2023
    Publication date: May 30, 2024
    Applicants: Hoffmann-La Roche Inc., Genentech, Inc.
    Inventors: HAIMING ZHANG, JIE XU, GEORG WUITSCHIK, REMY ANGELAUD, SEBASTIAN HEROLD, ALFRED STUTZ, TOBIAS BRUETSCH, JOHANNES BURKHARD
  • Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds
    Patent number: 11873305
    Abstract: Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.
    Type: Grant
    Filed: June 28, 2021
    Date of Patent: January 16, 2024
    Assignees: Genentech, Inc., Hoffmann-La Roche Inc.
    Inventors: Haiming Zhang, Jie Xu, Georg Wuitschik, Remy Angelaud, Sebastian Herold, Alfred Stutz, Tobias Bruetsch, Johannes Burkhard
  • ALTERNATIVE PROCESS FOR THE PREPARATION OF 4-PHENYL-5-ALKOXYCARBONYL-2-THIAZOL-2-YL-1,4-DIHYDROPYRIMIDIN-6-YL]METHYL]-3-OXO-5,6,8,8A-TETRAHYDRO-1H-IMIDAZO[1,5-A]PYRAZIN-2-YL]-CARBOXYLIC ACID
    Publication number: 20220315588
    Abstract: The present invention relates to an alternative process for synthesizing a compound of formula (I), R1 is phenyl, which is unsubstituted or substituted with one, two or three substituents independently selected from halogen and C1-6alkyl; R2 is C1-6alkyl; R3 is —CxH2—; x is 1, 2, 3, 4, 5, 6 or 7; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.
    Type: Application
    Filed: June 4, 2020
    Publication date: October 6, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Daniel Vincent FISHLOCK, Jianshu LIU, Paul SPURR, Georg WUITSCHIK, Zhixiang XU, Fugui ZHANG
  • PROCESSES FOR MAKING SERD TRICYCLIC COMPOUNDS HAVING A SUBSTITUTED PHENYL OR PYRIDINYL MOIETY
    Publication number: 20220002304
    Abstract: Provided herein are processes for the preparation of compounds useful in the treatment of cancer.
    Type: Application
    Filed: June 28, 2021
    Publication date: January 6, 2022
    Applicants: Genentech, Inc., Hoffmann-La Roche Inc.
    Inventors: HAIMING ZHANG, JIE XU, GEORG WUITSCHIK, REMY ANGELAUD, SEBASTIAN HEROLD, ALFRED STUTZ, TOBIAS BRUETSCH, JOHANNES BURKHARD
  • Process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one compounds
    Patent number: 10538536
    Abstract: The present invention relates to a process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one derivatives useful as pharmaceutically active compounds.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: January 21, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pascal Dott, Fabian Feyen, Stefan Hildbrand, Ursula Hoffmann, Fabienne Hoffmann-Emery, Roland Meier, Gerard Moine, Pankaj Rege, Georg Wuitschik
  • NOVEL PROCESS
    Publication number: 20190144468
    Abstract: The present invention relates to a process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one derivatives useful as pharmaceutically active compounds.
    Type: Application
    Filed: October 26, 2018
    Publication date: May 16, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Pascal DOTT, Fabian FEYEN, Stefan HILDBRAND, Ursula HOFFMANN, Fabienne HOFFMANN-EMERY, Roland MEIER, Gerard MOINE, Pankaj REGE, Georg WUITSCHIK