Patents by Inventor George A. Boswell, Jr.

George A. Boswell, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antihypercholesterolemic bis-trifluoromethyl-substituted imidazolines and derivatives thereof
    Patent number: 5428041
    Abstract: Provided are bis-trifluoromethyl-substituted imidazolines as inhibitors of Acyl-CoA:Cholesterol Acyltransferase (ACAT), processes for their preparation, pharmaceutical compositions, and therapeutic methods for their use as antihypercholesterolemic or antiatherosclerotic agents.
    Type: Grant
    Filed: March 4, 1992
    Date of Patent: June 27, 1995
    Assignee: The Du Pont Merck Pharmaceutical Company
    Inventors: Jeffrey T. Billheimer, George A. Boswell, Jr., Indawati De Lucca, Spencer Drummond, Jr., Peter J. Gillies, James M. Trzaskos
  • Cyclobutanone antibacterials
    Patent number: 4505905
    Abstract: Certain 7-oxobicyclo[3.2.0] hept-2-en-2-carboxylic acids, esters, and salts thereof useful as antibacterial agents or as intermediates for antibacterial agents, and methods for making and using them.
    Type: Grant
    Filed: April 15, 1982
    Date of Patent: March 19, 1985
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: George A. Boswell, Jr., Anthony J. Cocuzza
  • Antiinflammatory 4,5-diaryl-.alpha.-polyfluoroalkyl-1H-pyrrole-2-methanols and method for use thereof
    Patent number: 4495196
    Abstract: 4,5-Diaryl-.alpha.-polyfluoroalkyl-1H-pyrrole-2-methanols, such as 4,5-bis (4-fluorophenyl)-.alpha., .alpha.-bis (trifluoromethyl)-1H-pyrrole-2-methanol, are useful in treatment of inflammation and relieving pain.
    Type: Grant
    Filed: August 19, 1981
    Date of Patent: January 22, 1985
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: George A. Boswell, Jr.
  • Antiinflammatory 2,3-diaryl-5-[2,2,2-trifluoro-1-(trifluoromethyl]ethyl-1H-pyrroles
    Patent number: 4318917
    Abstract: Antiinflammatory 2,3-diaryl-5-[2,2,2-trifluoro-1-(trifluoromethyl)ethyl]-1H-pyrroles, such as 2,3-bis(4-fluorophenyl)-5-[2,2,2-trifluoro-1-(trifluoromethyl)ethyl]-1H-py rrole, useful for treating arthritis and related diseases.
    Type: Grant
    Filed: May 14, 1981
    Date of Patent: March 9, 1982
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Saul C. Cherkofsky, George A. Boswell, Jr.
  • Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both
    Patent number: 4241065
    Abstract: 6-Fluoro analogs of hydrocodone and oxycodone are analgesics and/or narcotic antagonists. Exemplary are 17-cyclopropylmethyl-4,5-epoxy-6,6-difluoro-3-methoxymorphinan and 17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-6-fluoro-3-methoxy- and -3-acetoxymorphinan.
    Type: Grant
    Filed: July 2, 1979
    Date of Patent: December 23, 1980
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: George A. Boswell, Jr., Rosetta M. Henderson
  • Preparation of vinylene fluorides
    Patent number: 4212815
    Abstract: A ketone is reacted with an N,N-disubstituted-aminosulfur trifluoride in the presence of a polar solvent, preferably also in the presence of a polar catalyst, to produce a vinylene fluoride. Exemplary is the reaction of cholestan-3.beta.-ol-6-one-3-t-butyl ether with diethylaminosulfur trifluoride in the presence of fuming sulfuric acid and tetrahydrofuran to produce 6-fluorocholesterol.
    Type: Grant
    Filed: July 5, 1978
    Date of Patent: July 15, 1980
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: George A. Boswell, Jr.