Abstract: The present invention provides compact spiral-wound filter elements having cassette-like performance. The invention further provides filtration systems (e.g., TFF systems) and processes (e.g., SPTFF processes) employing compact spiral-wound filter elements having cassette-like performance.

Abstract: The present invention provides compact spiral-wound filter elements having cassette-like performance. The invention further provides filtration systems (e.g., TFF systems) and processes (e.g., SPTFF processes) employing compact spiral-wound filter elements having cassette-like performance.

Abstract: A membrane-based separation device comprises multiple interconnected flat sheets of membrane bonded to a flexible film. The bonded films are bonded in a way to create an accordion or zig-zag shape. In certain embodiments, the first or upstream layer is affixed to a suitable housing, and the last or most downstream layer is also affixed to the suitable housing. The housing may contain an inlet port for the introduction of sample, and an outlet port for the removal of filtered sample. Flow through the segments is in parallel. Since the membranes are not folded or pleated, higher performance membranes (e.g., polysulfone based membranes with some degree of asymmetry) than those usable in pleated or folded systems can be used.

Abstract: The invention relates to a rapid recirculation based integrity testing of porous material and to an apparatus and system for performing the same.

Abstract: The invention relates to a rapid recirculation based integrity testing of porous material and to an apparatus and system for performing the same.

Abstract: The invention relates to a rapid recirculation based integrity testing of porous material and to an apparatus and system for performing the same.

Abstract: The invention relates to methods of isolating nucleic acids from a sample using a filter device comprising a plurality of membranes. The invention also provides for devices comprising a plurality of membranes and kits suitable for isolating nucleic acids from a sample. The invention also provides for nucleic acids which bind to at least a portion of a microorganism genome and methods of using the same.

Abstract: A depth filter design is disclosed which has little if any open void area upstream of the media. Preferably, it also has little if any open void area downstream of the media as well. A preferred embodiment uses layers of stacked, fibrous media with several of the layers being separated from the others by spacers which serve to compress the media and to prevent the bypass of fluid around the media adjacent the inner wall of the housing. Several designs for attaching the end caps which allow for the compression of the media are also disclosed.

Abstract: A multiwell filtration device having at least two liquid receiving reservoirs is disclosed in which at least one of the side walls includes one or more openings for passing liquid therethrough. A filtration membrane is sealingly adhered to the side wall covering the openings of each reservoir. The reservoirs are adapted to be positioned within the wells of a multiwell plate, which receives the filtrate passing from the reservoir through the membranes. The desired orientation of the reservoirs in the multiwell plate is retained before, during or after filtration to promote efficient automated sample handling techniques.