Abstract: There is provided a new and improved synthetic route for the synthesis of the compound 1-{2-[(1R)-1-aminoethyl]-4-chlorobenzyl}-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one (Formula (I)) that is readily scalable for commercial production. Also provided are important intermediate compounds that are formed in the new and improved synthetic route for the synthesis of the compound of formula (I).

Abstract: The present invention relates to method(s), apparatus and use(s) of apparatus for treating materials such as waste products and by-products of industrial processes e.g. slurries comprising solids and liquids, or, more particularly, slurries comprising solids, oil(s), and water. The invention further relates to method(s), apparatus and use(s) for treating slurry, the apparatus comprising a treatment chamber having a first end configured to receive slurry to be treated and a second end configured to allow egress of solids; at least one heated material conveyor configured to draw material comprising slurry and/or solids through the chamber in a direction from the first end towards the second end; the at least one heated material conveyor being further configured to heat and mix material comprising slurry and/or solids as these are drawn along; a condenser configured to receive vapours from the chamber and condense the vapours into liquid form.

Abstract: In one aspect the invention discloses an improved gas burner with a high turn-down ratio. The improved burner includes first and second gas flow passages, a flame front locator in one of the passages of the burner cap. Fuel gas is injected into an end of one of the passages and is ignited to establish a flame at the flame front locator. Secondary combustion air is provided through the other of the passages which on a high setting enables secondary combustion and on a low setting may mix with the hot gases and cool them resulting in a lower temperature at the cooking vessel.

Abstract: A method of providing an automobile exhaust catalyst composition. The method includes acidifying a support composition with a conjugate base oxide of an inorganic acid having a Ka to obtain an acidified support exhaust catalyst composition. The support composition includes a combination of a cerium-containing oxide compound and non-cerium-containing compound selected from the group consisting of alkali metal containing compounds, alkaline-earth metal containing compounds and combinations thereof.

Abstract: A method for forming thin edible pieces uses two continuous belts that cooperate to form a fill cavity. An edible mass, such as chocolate, is flowed into the fill cavity where it forms an edible blank which is transported on a belt path with the two belts moving in tandem. After the edible blank is released from the first or second continuous belt, a three-dimensional shape may be imparted to the edible blank at a forming station using one or more stamping dies or a forming drum. Using the techniques and apparatus described herein, novel edible products, and particularly novel chocolate products, can be made having shape characteristics that cannot be obtained using known molding or forming techniques.

Abstract: The present invention relates to a method of inhibiting or reducing the proliferation of prostate cancer cells, such as androgen independent prostate cancer (AIPC) cells, the method comprising administering to the cells a PLA2 inhibitor. In one embodiment the PLA2 inhibitor is a conformationally constrained molecule derived from a peptide consisting essentially of amino acid residues 70-74 of a human sPLA2-IIA protein, or the equivalent residues in other sPLA2 proteins.

Abstract: The present invention relates to a method of inhibiting or reducing the proliferation of prostate cancer cells, such as androgen independent prostate cancer (AIPC) cells, the method comprising administering to the cells a PLA2 inhibitor. In one embodiment the PLA2 inhibitor is a conformationally constrained molecule derived from a peptide consisting essentially of amino acid residues 70-74 of a human sPLA2-IIA protein, or the equivalent residues in other sPLA2 proteins.

Abstract: In one aspect the invention discloses a gas cooktop which is relatively easy to clean and which is not visually complex. The gas cooktop surface is provided with a trivet having two operating conditions. In a first condition the trivet is retracted and is substantially flush with the cooktop surface. In a second condition the trivet is extended to support a cooking vessel above a gas burner. In another aspect the invention discloses an improved gas burner with a high turn-down ratio. The improved burner includes first and second gas flow passages, a flame front locator, in one of the passages and a burner head. Fuel gas is injected into an end of one of said passages and is ignited to establish a flame at the flame front locator. Secondary combustion air is provided through the other of the passages which on a high setting enables secondary combustion and on a low setting may mix with the hot gases and cool them resulting in a lower temperature at the cooking vessel.

Abstract: Improved methods and apparatus for continuously molding chocolate are disclosed, including a method and apparatus for removing flash from chocolate pieces and products (both molded and otherwise); and a manifold for continuously providing liquid chocolate to a continuous mold and directing excess liquid chocolate away.

Abstract: A method for forming thin edible pieces uses two continuous belts that cooperate to form a fill cavity. An edible mass, such as chocolate, is flowed into the fill cavity where it forms an edible blank which is transported on a belt path with the two belts moving in tandem. After the edible blank is released from the first or second continuous belt, a three-dimensional shape may be imparted to the edible blank at a forming station using one or more stamping dies or a forming drum. Using the techniques and apparatus described herein, novel edible products, and particularly novel chocolate products, can be made having shape characteristics that cannot be obtained using known molding or forming techniques.

Abstract: A method of providing an automobile exhaust catalyst composition. The method includes acidifying a support composition with a conjugate base oxide of an inorganic acid having a Ka to obtain an acidified support exhaust catalyst composition. The support composition includes a combination of a cerium-containing oxide compound and non-cerium-containing compound selected from the group consisting of alkali metal containing compounds, alkaline-earth metal containing compounds and combinations thereof.

Abstract: A method for forming thin edible pieces uses two continuous belts that cooperate to form a fill cavity. An edible mass, such as chocolate, is flowed into the fill cavity where it forms an edible blank which is transported on a belt path with the two belts moving in tandem. After the edible blank is released from the first or second continuous belt, a three-dimensional shape may be imparted to the edible blank at a forming station using one or more stamping dies or a forming drum. Using the techniques and apparatus described herein, novel edible products, and particularly novel chocolate products, can be made having shape characteristics that cannot be obtained using known molding or forming techniques.

Abstract: According to one embodiment of the present invention, an enhanced NH3 adsorbing automotive exhaust composition including a catalyst composition suitable for use in a selective catalytic reduction (SCR) system and an acidified support composition for enhancing NH3 adsorption capacity of the automotive exhaust composition is disclosed.

Abstract: A lean NOx trap composition. The lean NOx trap composition utilizes ruthenium in place of higher cost metals such as platinum. The lean NOx trap composition provides high NOx storage efficiency and high NOx conversion efficiency when incorporated in a lean NOx trap. A method of removing harmful gases using the lean NOx trap composition is also described.

Abstract: Improved methods and apparatus for continuously molding chocolate are disclosed, including a method and apparatus for removing flash from chocolate pieces and products (both molded and otherwise); and a manifold for continuously providing liquid chocolate to a continuous mold and directing excess liquid chocolate away.

Abstract: Ice detection apparatus for monitoring ice accretion on aircraft surfaces, comprising an array of optical fibres which are mounted flush with an outer surface of an aircraft skin, and an intermediately located electromagnetic radiation emitter which is provided by an optical fibre. In use radiation is emitted by the emitter generally outwardly of the aircraft surface, and the layer of accreted ice diffuses the emitted radiation scattered and reflected. The diffused radiation is detected by the sensors, and the spatial distribution of the detected intensity diffused radiation about the emitter can be used to calculate the thickness of the layer of ice and the type of ice.

Abstract: Improved methods and apparatus for continuously molding chocolate are disclosed, including a method and apparatus for removing flash from chocolate pieces and products (both molded and otherwise); and a manifold for continuously providing liquid chocolate to a continuous mold and directing excess liquid chocolate away.

Abstract: A method for acquiring a gel-forming polymer and an absorbent article containing the gel-forming polymer. In one embodiment, the method includes the steps of providing a Hagfish, stimulating the Hagfish to excrete a gel-forming polymer, and drying the gel-forming polymer. In another embodiment, the method for acquiring a gel-forming polymer includes the steps of providing a Hagfish, placing the Hagfish in a container of water, stimulating the Hagfish to excrete a gel-forming polymer into the water, and drying the gel-forming polymer.

Abstract: In one aspect the invention discloses an improved gas burner with a high turn-down ratio. The improved burner includes first and second gas flow passages (44, 47), a flame front locator (49) in one of the passages of the burner head. Fuel gas is injected into an end of one of one of the passages (47) and is ignited to establish a flame at the flame front locator (49). Secondary combustion air is provided through the other of the passages (44) which on a high setting enables secondary combustion and on a low setting may mix with the hot gases and cool them resulting in a lower temperature at the cooking vessel.

Abstract: The present invention relates to a method of inhibiting or reducing the proliferation of prostate cancer cells, such as androgen independent prostate cancer (AIPC) cells, the method comprising administering to the cells a PLA2 inhibitor. In one embodiment the PLA2 inhibitor is a conformationally constrained molecule derived from a peptide consisting essentially of amino acid residues 70-74 of a human sPLA2-IIA protein, or the equivalent residues in other sPLA2 proteins.