Abstract: The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

Abstract: Technical solutions are described for disturbance feedforward compensation technique for improving the disturbance rejection properties of a closed loop position control system using a cascaded control structure with an inner velocity and outer position control loops. According to one or more embodiments, a system includes a position controller that receives an input rack-position command, and a measured rack-position, and computes a velocity command based on a difference in the input rack-position command and the measured rack-position. The system further includes a velocity controller that receives the velocity command, and a measured motor velocity, and computes an input torque command based on a difference in the velocity command and the measured motor velocity. The system adjusts a position of a rack by generating an amount of torque corresponding to the applying the input torque command to a motor.

Abstract: An indoor golf game, Tin Cup features super-lightweight, balanced balls that look like golf balls and fly, spin and land on a target golf green with very similar characteristics of standard golf shots. The target green has over 130 different setups of slope and hole combinations, and there are 8 different hole lengths, making for over 100 different hole set-ups with detailed setup and scoring instructions. Tin Cup can be played in a variety of ways that parallel the different types of standard golf games. Golf's chipping/pitching game is very difficult to master, and Tin Cup is also very difficult to master, providing incredibly accurate practice feedback that translates well when playing standard golf.

Abstract: An opacity engine for automatically and dynamically setting an opacity level for a scatterplot based on a predetermined value for a mean opacity level of utilized pixels (MOUP) in the scatterplot. The opacity engine may automatically set the opacity level for the scatterplot to produce the predetermined MOUP value in the scatterplot. A utilized pixel in the scatterplot comprises a pixel displaying at least one data point representing data. The MOUP value in the scatterplot may be equal to the sum of the final opacity levels of all utilized pixels in the chart, divided by the number of utilized pixels in the chart. The predetermined MOUP value may be between 35%-45%, such as 40%. The opacity engine may adjust the determined opacity level for charts having relatively low over-plotting factors.

Abstract: Controller, control actuator and bleed valve including a first chamber for the circulation of a discharge air stream when the valve is open and preventing it when the valve is closed, an inner housing, in which a mobile blocking unit is moved between a position for opening and a position for closing the valve, this unit delimiting, in the inner housing, two chambers, the second chamber including a mechanism for returning the blocking unit to the open position, and the third chamber, being used to be in fluidic connection with the control actuator in order to actuate the blocking unit against the return mechanism, the three chambers being isolated in a sealed manner from one another by way of the blocking unit. The device includes a regulation valve.

Abstract: A processing system for a motorized mobile system includes at least one sensor to measure one or more kinematic states of an object proximate to the motorized mobile system and at least one processor to use at least one state estimation filter and at least one object kinematic model. The processor uses the at least one state estimation filter and the at least one object kinematic model to predict a first kinematic state estimate of the object based on a prior knowledge of state for the object and output the predicted first kinematic state estimate of the object from the state estimation filter for use by at least one other process of the motorized mobile system, wherein the at least one other process causes one or more actions to be taken by the motorized mobile system based on the predicted first kinematic state estimate of the object.

Abstract: Controller for controlling a bleed valve including a first body with an internal cavity connected to an air inlet port and an air outlet port, a second body including a chamber, a mobile member in the cavity and in the chamber, connecting the two bodies. The member is mobile between a position whereby the ports fluidly communicate and a position whereby the ports are isolated, the member further including two pistons housed in the chamber and defining in this chamber at least two spaces. The controller also includes a fluid supply for at least one of the spaces for the purpose of moving the pistons in the chamber.

Abstract: Examples herein disclose an apparatus. The apparatus includes a first socket nested in a second socket. The first socket includes a cavity, disposed in the first socket, to accept a chipset. The first socket includes an electrical contact, disposed in the cavity, to couple the chipset to a board. The chipset detects when a modular infrastructure is coupled to the second socket.

Abstract: Methods of making mutant Cas9 proteins are described.

Abstract: The present disclosure describes a system, method and computer readable medium capable of verifying healthcare encounters. In one embodiment, an electronic verification process is described which may utilize geographical information to determine the proximity of a health care worker to the patient during a scheduled healthcare visit. The proximity information may then be compared to a threshold value and an electronic signature screen may be presented to the patient based upon the results of the comparison. In one embodiment, a time stamp may be generated and stored to provide confirmation as to the time that the patient's electronic signature was obtained via the electronic signature screen. Verification information stored by the system may be used to simplify the verification process, hasten payments to healthcare organizations and protect against healthcare fraud.

Abstract: A system, method, and computer program product are provided to: display, utilizing the touchscreen, a grid of a plurality of photos; receive, utilizing the touchscreen, an indication of a touch input for selection of a first photo of a subset of the plurality of photos in the grid; in response to the receipt of the indication of the touch input for selection of the first photo of the subset of the plurality of photos in the grid, cause selection of the first photo of the subset of the plurality of photos in the grid, utilizing the one or more processors; receive, utilizing the touchscreen, an indication of a continuation of the touch input for selection of a second photo of the subset of the plurality of photos in the grid; in response to the receipt of the indication of the continuation of the touch input for selection of the second photo of the subset of the plurality of photos in the grid, cause selection of the second photo of the subset of the plurality of photos in the grid, utilizing the one or more pr

Abstract: A seal system for an oil-filled cable termination including a cable extending through each of a cable gland and a stress cone that is spaced apart from the cable gland. The seal system includes: a first oil seal layer surrounding the cable between the cable gland and the stress cone; a second oil seal layer overlapping and contacting the first oil seal layer; a first oil barrier layer overlapping and contacting an upper portion of the second oil seal layer; a second oil barrier layer overlapping and contacting a lower portion of the second oil seal layer, the second oil barrier layer spaced apart from the first oil barrier layer; and a heat shrinkable tube secured around the first and second oil barrier layers.

Abstract: The present disclosure relates to making payments with a mobile device. In one example process, the mobile device receives and stores information for one or more payment accounts on the mobile device. The mobile device is used to make payments using the payment accounts. In some examples, authorization to proceed with a payment is performed before each purchase made by the user. The authorization process can include receiving a verification of the user, such as a fingerprint scan or passcode. In some examples, a payment account is selected from among available payment accounts. In some examples, an indication is displayed of a digital item associated with a purchased item. In some examples, a payment transaction is initiated with participants of an ongoing communication. In some examples, an application of a retailer is invoked based on the availability of the application. In some examples, a purchase recommendation is provided.

Abstract: The present invention, therefore, is directed to an antimicrobial compositions that decreases the bioavailability of iron by introducing a higher-affinity iron-selective chelating agent capable of competing with microbial siderophores. In one aspect, the present invention relates to an antimicrobial composition including a potentiating antimicrobial composition including one or more antimicrobial agents and a chelator having a weight ratio of the antimicrobial agent to the chelator from about 1:1000 to about 1000:1.

Abstract: A system and method for dynamically (re)configuring a service network based on profile information obtained from a Big Data Analytics platform. Received dynamic situation profiles relative to network states, subscriber states, etc. may be compared against corresponding characteristic situation profiles. If there is a similarity, a dynamic design change action may be effectuated for changing configuration of at least a part of the service network, e.g., a service chaining mechanism, operating to service user data flows of the subscribers.

Abstract: A battery system includes a battery, a monitoring circuit, a wireless communication device and a remote wireless communication unit, and a deployable drone parachute. The monitoring circuit includes a processing unit and non-volatile memory that stores a unique identification of the battery. The wireless communication device is disposed on the battery and is in data communication with sensor circuits. The wireless communication device transmits real time operational parameter data sensed by the sensor circuits. The remote wireless communication unit is in wireless data communication with the wireless communication device and receives the operational parameter data therefrom.

Abstract: The present invention relates to a drug delivery system comprising a core and a shell in which the core comprises a hydrolytically degradable polymer X which polymer backbone comprises pendant ester and acid functionalities and in which the shell comprises a hydrolytic degradable polymer Y. The hydrolytic degradable polymers X and Y are different polymers. Polymer X further comprises amino-acids in the polymer backbone and degrades via zero order degradation kinetics for a period of at least 3 months. Polymer Y degrades via auto-acceleration degradation kinetics.