Patents by Inventor George Anello Chiarello

George Anello Chiarello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for making hydrazides
    Patent number: 9738602
    Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: August 22, 2017
    Assignee: Wyeth LLC
    Inventors: George Anello Chiarello, Ayman Sahli
  • PROCESSES FOR MAKING HYDRAZIDES
    Publication number: 20160176809
    Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
    Type: Application
    Filed: December 18, 2015
    Publication date: June 23, 2016
    Applicant: WYETH LLC
    Inventors: George Anello CHIARELLO, Ayman SAHLI
  • Processes for making hydrazides
    Patent number: 9227924
    Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: January 5, 2016
    Assignee: WYETH LLC
    Inventors: George Anello Chiarello, Ayman Sahli
  • PROCESSES FOR MAKING HYDRAZIDES
    Publication number: 20150099865
    Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
    Type: Application
    Filed: October 2, 2014
    Publication date: April 9, 2015
    Applicant: WYETH LLC
    Inventors: George Anello CHIARELLO, Ayman SAHLI
  • Processes for making hydrazides
    Patent number: 8853451
    Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: October 7, 2014
    Assignee: Wyeth LLC
    Inventors: George Anello Chiarello, Ayman Sahli
  • PROCESSES FOR MAKING HYDRAZIDES
    Publication number: 20130211053
    Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
    Type: Application
    Filed: January 31, 2013
    Publication date: August 15, 2013
    Applicant: WYETH LLC
    Inventors: George Anello CHIARELLO, Ayman SAHLI
  • Processes for making hydrazides
    Patent number: 8383857
    Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: February 26, 2013
    Assignee: Wyeth LLC
    Inventors: George Anello Chiarello, Ayman Sahli
  • PROCESSES FOR MAKING HYDRAZIDES
    Publication number: 20120130052
    Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
    Type: Application
    Filed: January 27, 2012
    Publication date: May 24, 2012
    Applicant: WYETH LLC
    Inventors: George Anello CHIARELLO, Ayman SAHLI
  • Processes for making hydrazides
    Patent number: 8110705
    Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
    Type: Grant
    Filed: May 20, 2008
    Date of Patent: February 7, 2012
    Assignee: Wyeth LLC
    Inventors: George Anello Chiarello, Ayman Sahli
  • PROCESSES FOR MAKING HYDRAZIDES
    Publication number: 20080312422
    Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
    Type: Application
    Filed: May 20, 2008
    Publication date: December 18, 2008
    Applicant: Wyeth
    Inventors: George Anello Chiarello, Ayman Sahli