Patents by Inventor George Avgerinos

George Avgerinos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9913902
    Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: March 13, 2018
    Assignee: ABBVIE BIOTECHNOLOGY LTD.
    Inventors: Min M. Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Publication number: 20180036407
    Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Application
    Filed: September 28, 2017
    Publication date: February 8, 2018
    Inventors: Min M. Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Publication number: 20170136122
    Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Application
    Filed: June 7, 2016
    Publication date: May 18, 2017
    Inventors: Min M. Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Patent number: 9328165
    Abstract: The invention provides a method for producing a host cell protein—(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: May 3, 2016
    Assignee: AbbVie Biotechnology Ltd.
    Inventors: Min M. Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Patent number: 9273132
    Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: March 1, 2016
    Assignee: AbbVie Biotechnology Ltd
    Inventors: Min M. Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Publication number: 20150361169
    Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Application
    Filed: August 31, 2015
    Publication date: December 17, 2015
    Inventors: Min M. Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Publication number: 20150361168
    Abstract: The invention provides a method for producing a host cell protein—(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Application
    Filed: August 31, 2015
    Publication date: December 17, 2015
    Inventors: Min M. Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Publication number: 20150307605
    Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Application
    Filed: July 10, 2015
    Publication date: October 29, 2015
    Inventors: Min M. Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Patent number: 9102723
    Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: August 11, 2015
    Assignee: AbbVie Biotechnology Ltd
    Inventors: Min M Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Patent number: 9096666
    Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: August 4, 2015
    Assignee: AbbVie Biotechnology Ltd
    Inventors: Min M Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Publication number: 20150175694
    Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1? and IL-1? and neutralize IL-1? and IL-1? activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL-1? and IL-1?) and for inhibiting the activity of the antigens, e.g., in a human subject suffering from a disorder in which IL-1? and/or IL-1? activity is detrimental.
    Type: Application
    Filed: March 5, 2015
    Publication date: June 25, 2015
    Applicant: ABBVIE INC.
    Inventors: Albert COLLINSON, George Avgerinos, Richard DIXON, Tariq GHAYUR, Zehra KAYMAKCALAN
  • Publication number: 20150079102
    Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Application
    Filed: November 21, 2014
    Publication date: March 19, 2015
    Inventors: Min M Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Publication number: 20150079103
    Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Application
    Filed: November 21, 2014
    Publication date: March 19, 2015
    Inventors: Min M Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Publication number: 20140378666
    Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1? and IL-1? and neutralize IL-1? and IL-1? activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL-1? and IL-1?) and for inhibiting the activity of the antigens, e.g., in a human subject suffering from a disorder in which IL-1? and/or IL-1? activity is detrimental.
    Type: Application
    Filed: August 26, 2014
    Publication date: December 25, 2014
    Applicant: ABBVIE INC.
    Inventors: Albert COLLINSON, George Avgerinos, Richard DIXON, Tariq GHAYUR, Zehra KAYMAKCALAN
  • Patent number: 8916153
    Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: December 23, 2014
    Assignee: AbbVie Biotechnology Ltd.
    Inventors: Min M. Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Patent number: 8906372
    Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: December 9, 2014
    Assignee: AbbVie Biotechnology Ltd.
    Inventors: Min Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Patent number: 8895009
    Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: November 25, 2014
    Assignee: AbbVie Biotechnology Ltd.
    Inventors: Min Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Patent number: 8883156
    Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: November 11, 2014
    Assignee: AbbVie Biotechnology Ltd.
    Inventors: Min M. Wan, George Avgerinos, Gregory Zarbis-Papastoitsis
  • Publication number: 20140155579
    Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1? and IL-1? and neutralize IL-1? and IL-1? activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL-1? and IL-?) and for inhibiting the activity of the antigens, e.g., in a human subject suffering from a disorder in which IL-1? and/or IL-1? activity is detrimental.
    Type: Application
    Filed: May 23, 2013
    Publication date: June 5, 2014
    Applicant: AbbVie Inc.
    Inventors: Albert Collinson, George Avgerinos, Richard Dixon, Tariq Ghayur, Zehra Kaymakcalan
  • Publication number: 20130323261
    Abstract: The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained.
    Type: Application
    Filed: August 2, 2013
    Publication date: December 5, 2013
    Inventors: Min Wan, George Avgerinos, Gregory Zarbis-Papastoitsis