Patents by Inventor George Boguslawski

George Boguslawski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Proteases of altered stability to autolytic degradation
    Patent number: 5543302
    Abstract: Proteases are susceptible to autolytic degradation. The method of the invention provides a method to identify susceptible autolysis sites which are cleaved to produce a few discrete fragments. Once identified, amino acid(s) at or in the vicinity of the cleavage site may be chemically modified or the DNA sequence capable of encoding the amino acid present at the site may be changed or deleted by site directed mutagenesis to produce an autolysis stable protease. The invention is particularly applicable to alkaline proteases which are produced in large quantities and used as detergent additives. Stable alkaline proteases could then be used in liquid detergent formulations.
    Type: Grant
    Filed: November 30, 1993
    Date of Patent: August 6, 1996
    Assignee: Solvay Enzymes, Inc.
    Inventors: George Boguslawski, Josephine Grosch, John W. Shultz, Sethuraman Subramanian
  • Bleach stable enzymes
    Patent number: 5118623
    Abstract: The methods of the invention can be used to identify sites of cleavage of an enzyme in the presence of hypochlorite. It has been found that such cleavage occurs at tryptophan. Chemical modifications or genetic manipulation to change or delete tryptophan can be done to produce a more stable enzyme which retains activity in the presence of hypochlorite. The invention is particularly applicable to alkaline proteases which are useful in detergent compositions.
    Type: Grant
    Filed: May 27, 1988
    Date of Patent: June 2, 1992
    Assignee: Solvay Enzymes, Inc.
    Inventors: George Boguslawski, John W. Shultz
  • Use of glucose oxime to increase glucose isomerase activity in bacterial cells
    Patent number: 4510247
    Abstract: Disclosed is a method of increasing the production of enzymes involved in carbohydrate metabolism by bacterium of the species F. arborescens or E. coli. The method involves growing the bacterium on an aqueous nutrient medium containing glucose oxime.
    Type: Grant
    Filed: February 9, 1983
    Date of Patent: April 9, 1985
    Assignee: Miles Laboratories, Inc.
    Inventors: Beth E. Whitted, George Boguslawski
  • Preparation of an alkaline protease from flavobacterium arborescens
    Patent number: 4429044
    Abstract: The production of an alkaline serine protease by a soil bacterium, Flavobacterium arborescens is disclosed. Also disclosed is the use of the protease as an enzyme detergent.
    Type: Grant
    Filed: September 28, 1982
    Date of Patent: January 31, 1984
    Assignee: Miles Laboratories, Inc.
    Inventors: George Boguslawski, Ernest W. Boyer
  • Novel strain of Bacillus licheniformis useful in the production of glucose isomerase and method of screening Bacillus mutants for ability to produce glucose isomerase in the absence of xylose
    Patent number: 4355103
    Abstract: A novel strain of Bacillus licheniformis, ATCC 31667, capable of producing glucose isomerase in the absence of xylose is disclosed. Also disclosed is a novel method for screening Bacillus mutants for this property.
    Type: Grant
    Filed: January 23, 1981
    Date of Patent: October 19, 1982
    Assignee: Miles Laboratories, Inc.
    Inventors: George Boguslawski, Michael J. Rynski