Patents by Inventor George C. Buzby, Jr.
George C. Buzby, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5144072Abstract: This invention provides Class III anti-arrhythmic agents of the formula: ##STR1## in which R.sup.1 is alkylsulfonamido, R.sup.2 is ethyl, R.sup.3 is hydrogen, R.sup.4 is ethyl, and n is 2 to 4, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: October 21, 1988Date of Patent: September 1, 1992Assignee: American Home Products CorporationInventors: George C. Buzby, Jr., Thomas J. Colatsky
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Patent number: 4794196Abstract: N-Aminoalkyl(perfluoroalkanoylaminophenyl)sulfonic acid amides of the formula: ##STR1## in which R.sup.1 is perfluoroalkanoylamino of 2 to 4 carbon atoms, in 3- or 4- position of the benzene ring;R.sup.2 is hydrogen or alkyl of 1 to 4 carbon atoms;R.sup.3 is hydrogen or straight or branched chain alkyl of 1 to 4 carbon atoms;R.sup.4 is straight or branched chain alkyl of 1 to 4 carbon atoms; andn is one of the integers 2, 3 or 4;or a pharmaceutically acceptable salt thereof, are Class I anti-arrhythmic agents useful in the treatment of cardiac arrhythmias and conditions characterized by coronary arteries vasospasm and myocardial ischemia.Type: GrantFiled: February 10, 1987Date of Patent: December 27, 1988Assignee: American Home Products CorporationInventors: George C. Buzby, Jr., Thomas J. Colatsky
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Patent number: 4727183Abstract: Disclosed herein is a process for producing an asymmetric indoline-2-carboxylic acid of the structural Formula: ##STR1## wherein X is hydrogen, bromine, chlorine, C.sub.1-4 alkyl or C.sub.1-4 alkoxy, which comprises:(a) assymetrically reducing an o-nitrophenylpyruvic acid III by contacting the acid III with a reducing complex formed from (R)-proline or (S)-proline, respectively, and sodium borohydride in an inert solvent to form, respectively, an (S) or (R)-.alpha.-hydroxy-2-nitrobenzenepropanoic acid IV;(b) reacting, respectively, said (S) or (R)-.alpha.-hydroxy-2-nitrobenzenepropanoic acid III with a Vilsmeier chlorinating reagent in which the chlorinating agent thereof is selected from a group consisting of thionyl chloride, oxalyl chloride, phosphorus oxychloride, phosphorus pentachloride and sulfuryl chloride and the amide thereof is selected from a group consisting of dimethylformamide, diethylformamide, dimethylacetamide and diethylacetamide, said reaction being run at temperatures of at least 20.Type: GrantFiled: October 31, 1986Date of Patent: February 23, 1988Assignee: American Home Products CorporationInventors: George C. Buzby, Jr., Michael W. Winkley, Ronald J. McCaully
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Patent number: 4721809Abstract: This invention provides Class III anti-arrhythmic agents of the formula: ##STR1## in which R.sup.1 is alkylsulfonamido, arylsulfonamido, perfluoroalkylsulfonamido, R.sup.2 and R.sup.3 are hydrogen or alkyl, R.sup.4 is alkyl, and n is 2 to 4, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: September 18, 1986Date of Patent: January 26, 1988Assignee: American Home Products CorporationInventors: George C. Buzby, Jr., Thomas J. Colatsky
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Patent number: 4720580Abstract: This invention provides a group of anti-arrhythmic agents of the formula: ##STR1## in which R.sup.1 is hydrogen, hydroxy, alkoxy or halo;R.sup.2 is hydrogen, alkoxy, halo or trifluoromethyl, with the proviso that R.sup.2 is not hydrogen when R.sup.1 is hydrogen;R.sup.3 is alkyl or, when R.sup.2 is trifluoromethyl and R.sup.1 is hydrogen, R.sup.3 may be hydrogen;R.sup.4 is alkyl, cycloalkyl or cycloalkylmethyl;R.sup.5 is hydrogen or alkyl;n is 2-4;or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 11, 1986Date of Patent: January 19, 1988Assignee: American Home Products CorporationInventor: George C. Buzby, Jr.
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Patent number: 4698445Abstract: N-Aminoalkyl(aminophenyl)sulfonic acid amides of the formula: ##STR1## in which R.sup.1 is --NH.sub.2, alkylamino of 1 to 3 carbon atoms or alkanoylamino of 2 to 4 carbon atoms, in 3- or 4-position of the benzene ring;R.sup.2 is hydrogen or alkyl of 1 to 4 carbon atoms;R.sup.3 is hydrogen or straight or branched chain alkyl of 1 to 4 carbon atoms;R.sup.4 is straight or branched chain alkyl of 1 to 4 carbon atoms; with the proviso that R.sup.3 and R.sup.4 are branched chain alkyl when R.sup.2 is hydrogen;and n is one of the integers 2, 3 or 4;or a pharmaceutically acceptable salt thereof, an anti-arrhythmic agents useful in the treatment of cardiac arrhythmias and conditions characterized by coronary arteries vasospasm.Type: GrantFiled: June 18, 1986Date of Patent: October 6, 1987Assignee: American Home Products CorporationInventors: George C. Buzby, Jr., Thomas J. Colatsky
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Patent number: 4665227Abstract: Compounds presenting the following structural formula: ##STR1## in which the nitro substituent is in 3 or 4 position of the phenyl ring; R.sup.1 is hydrogen or alkyl;R.sup.2 is alkyl;R.sup.3 is hydrogen or alkyl;and n is one of the integers 0, 1 or 2;or a pharmaceutically acceptable salt thereof, are Class III anti-arrhythmic agents.Type: GrantFiled: May 23, 1986Date of Patent: May 12, 1987Assignee: American Home Products CorporationInventors: Thomas J. Colatsky, George C. Buzby, Jr.
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Patent number: 4644081Abstract: Disclosed herein is a process for producing an asymmetric indoline-2-carboxylic acid of the structural Formula: ##STR1## wherein X is hydrogen, bromine, chlorine, C.sub.1-4 alkyl or C.sub.1-4 alkoxy, which comprises:(a) assymetrically reducing an o-nitrophenylpyruvic acid III by contacting the acid III with a reducing complex formed from (R)-proline or (S)-proline, respectively, and sodium borohydride in an inert solvent to form, respectively, an (S) or (R)-.alpha.-hydroxy-2-nitrobenzenepropanoic acid IV;(b) reacting, respectively, said (S) or (R)-.alpha.-hydroxy-2-nitrobenzenepropanoic acid III with a Vilsmeier chlorinating reagent in which the chlorinating agent thereof is selected from a group consisting of thionyl chloride, oxalyl chloride, phosphorus oxychloride, phosphorus pentachloride and sulfuryl chloride and the amide thereof is selected from a group consisting of dimethylformamide, diethylformamide, dimethylacetamide and diethylacetamide, said reaction being run at temperatures of at least 20.Type: GrantFiled: February 14, 1986Date of Patent: February 17, 1987Assignee: American Home Products CorporationInventors: George C. Buzby, Jr., Michael W. Winkley, Ronald J. McCaully
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Patent number: 4618711Abstract: Compounds of the formula: ##STR1## in which Z is ##STR2## where R is hydrogen, alkyl, polyfluorinated alkyl, --CN, cyanoalkyl, cycloalkyl or cycloalkylalkyl;R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7, independently, are hydrogen, alkoxy, trifluoromethyl or halo;R.sup.8 is hydrogen or alkyl;or a pharmaceutically acceptable salt thereof, are useful as anti-arrhythmic agents.Type: GrantFiled: March 29, 1985Date of Patent: October 21, 1986Assignee: American Home Products CorporationInventor: George C. Buzby, Jr.
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Patent number: 4614806Abstract: Disclosed herein is a process for producing an asymmetric indoline-2-carboxylic acid of the structural Formula: ##STR1## wherein X is hydrogen, bromine, chlorine, C.sub.1-4 alkyl or C.sub.1-4 alkoxy, which comprises:(a) assymetrically reducing an o-nitrophenylpyruvic acid III by contacting the acid III with a reducing complex formed from (R)-proline or (S)-proline, respectively, and sodium borohydride in an inert solvent to form, respectively, an (S) or (R)-.alpha.-hydroxy-2-nitrobenzenepropanoic acid IV;(b) reacting, respectively, said (S) or (R)-.alpha.-hydroxy-2-nitrobenzenepropanoic acid III with a Vilsmeier chlorinating reagent in which the chlorinating agent thereof is selected from a group consisting of thionyl chloride, oxalyl chloride, phosphorus oxychloride, phosphorus pentachloride and sulfuryl chloride and the amide thereof is selected from a group consisting of dimethylformamide, diethylformamide, dimethylacetamide and diethylacetamide, said reaction being run at temperatures of at least 20.Type: GrantFiled: February 11, 1985Date of Patent: September 30, 1986Assignee: American Home Products CorporationInventors: George C. Buzby, Jr., Michael W. Winkley, Ronald J. McCaully
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Patent number: 4587360Abstract: An anti-arrhythmic agent which is N-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-N-(1-methylethyl)- 2,3,4-trimethoxy-benzenesulfonamide or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 16, 1985Date of Patent: May 6, 1986Assignee: American Home Products CorporationInventor: George C. Buzby, Jr.
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Patent number: 4559178Abstract: Disclosed herein is a process for the preparation of optically active compounds of the formula: ##STR1## in which R is a lower alkyl, lower alkoxy, benzyloxy, phenyl, o-nitrophenyl, p-nitrophenyl, or p-tolyl group, or salts or esters thereof, which process comprises the following steps:(a) starting with a racemic mixture of the compound of Formula I in which R is phenyl, namely, (+)-3-benzoylthio-2-methylpropanoic acid;(b) adding thereto 0.40-0.Type: GrantFiled: April 9, 1982Date of Patent: December 17, 1985Assignee: American Home Products CorporationInventors: George C. Buzby, Jr., Henry G. Schouten
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Patent number: 4539426Abstract: Compounds of the formula: ##STR1## in which Y is --(CH.sub.2).sub.n -- where n is one of the integers 1,2,3 or 4 or ##STR2## where R is hydrogen, alkyl, polyfluorinated alkyl, --CN, cyanoalkyl, cycloalkyl or cycloalkylalkyl;R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7, independently, are hydrogen, alkoxy, trifluoromethyl or halo;R.sup.8 is hydrogen or alkyl;R.sup.9 is alkyl;R.sup.10 is alkyl;m is one of the integers 0 or 1;p is one of the integers 0, 1, 2 or 3; ands is one of the integers 0 or 1;or a pharmaceutically acceptable salt thereof, are useful as anti-arrhythmic agents.Type: GrantFiled: May 11, 1984Date of Patent: September 3, 1985Assignee: American Home Products CorporationInventor: George C. Buzby, Jr.
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Patent number: 4520205Abstract: Described herein is a process for separating the enantiomers of (+)-2,3-dihydroindole-2-carboxylic acid, which process utilizes (+) or (-)-ephedrine as the resolving agent. The resolved acids are useful as intermediates in the preparation of angiotensin converting enzyme inhibitors.Type: GrantFiled: February 10, 1984Date of Patent: May 28, 1985Assignee: American Home Products CorporationInventor: George C. Buzby, Jr.