Abstract: Described herein are methods and computer systems for classification of CD8 T-cell topology using a patient response-based linear cutoff model. A plurality of histology images of tissue samples in a plurality of patients are received by a computer system. An image analysis of the plurality of histology images is performed to obtain a CD8+ T-cell abundance in the tumor parenchyma and stroma in each of the plurality of histology images. Real inflammation scores and tumor infiltration scores are determined based on a polar coordinate transformation of the CD8+ T-cell abundance in the tumor parenchyma and stroma. Based on the real inflammation scores and tumor infiltration scores, a feature space is generated, and linear boundaries or linear cutoffs between a plurality of classifications in the feature space are identified based on the real inflammation scores, the tumor infiltration scores, and patient response data.

Abstract: Described herein are methods and computer systems for classification of CD8 T-cell topology using artificial intelligence and machine learning. A plurality of histology images of tissue samples in a plurality of patients are received by a computer system. An image analysis of the plurality of histology images is performed to obtain a CD8+ T-cell abundance in the tumor parenchyma and stroma in each of the plurality of histology images. A machine learning algorithm is then trained using results of the image analysis and the CD8+ T-cell abundance in the tumor parenchyma and stroma. Based on the training, a machine learning feature space comprising a plurality of classifications is generated, and boundaries between the plurality of classifications in the machine learning feature space are identified.

Abstract: The present disclosure provides methods of identifying a subject suitable for an anti-PD-?PD-L1 antagonist therapy comprising measuring assay CD8 localization and PD-L1 expression in a tumor sample obtained from the subject. In some aspects, method further comprises administering (i) an anti-PD-?PD-L1 antagonist therapy or (ii) an anti-PD-?PD-L1 antagonist and anti-CT-LA-4 antagonist combination therapy to a subject identified as having a tumor exhibiting an excluded CD8 localization phenotype, wherein the tumor is PD-L1 negative.

Abstract: The disclosure provides LAG-3 antagonists and methods comprising the same for treating a cancer in a subject based on a LAG-3 density score and/or a LAG-3 proportion score in a tumor sample from the subject. The disclosure also provides methods of identifying a subject responsive to a LAG-3 antagonist therapy.

Abstract: The present disclosure provides methods of identifying a subject suitable for an immunooncology (I-O) therapy comprising measuring the expression of one or more of STAT1, IFN?, NECTIN2, and CSFIR. In some aspects, the I-O therapy comprises administering an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or antigen-binding portion thereof to the subject.

Abstract: The present disclosure provides methods of identifying a subject suitable for an immuno-oncology (I-O) therapy comprising measuring the expression of one or more of STAT1, IFN?, NECTIN2, and CSF1R. In some aspects, the I-O therapy comprises administering an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or antigen-binding portion thereof to the subject.

Abstract: Systems and methods for controlling object/document access in a content management system. The content management system may have several layers of access controls, which may include a layer of access control at the object level, a layer of access control at the row level and a layer of access control at the field level. Access may be controlled at the object level by a user's security profile, at the object record level (or row level) by the user's role, and/or at the object field level by the user's role or a state in a document lifecycle. In other words, the object level access control may grant access (e.g., Create, Read, Edit and Delete) on objects, the object record level access control may grant access (e.g., Read, Edit and Delete) on object records, and field level access control may grant access (e.g., Read, Edit and Hidden) on object field level.

Abstract: Systems and methods for controlling object/document access in a content management system. The content management system may have several layers of access controls, which may include a layer of access control at the object level, a layer of access control at the row level and a layer of access control at the field level. Access may be controlled at the object level by a user's security profile, at the object record level (or row level) by the user's role, and/or at the object field level by the user's role or a state in a document lifecycle. In other words, the object level access control may grant access (e.g., Create, Read, Edit and Delete) on objects, the object record level access control may grant access (e.g., Read, Edit and Delete) on object records, and field level access control may grant access (e.g., Read, Edit and Hidden) on object field level.

Abstract: A friction damper comprises a channel member including at least one friction channel and a wedge member including at least one friction wedge received by a corresponding friction channel for sliding motion along the channel relative to the channel member. Each friction channel has a pair of internal sidewalls connected by an internal transverse wall, wherein at least one of the pair of sidewalls forms an obtuse angle with the transverse wall. In a preferred construction, the sidewalls are symmetrically convergent as they approach the connecting transverse wall. Each friction wedge includes a pair of external sidewalls parallel to the internal sidewalls of the channel, wherein the external sidewalls of the friction wedge are movable into surface-to-surface engagement with the internal sidewalls of the friction channel by adjusting the depth of receipt of the friction wedge in the friction channel.

Abstract: A seismic isolation bearing comprises a lower plate, an upper plate, and a cylindrical roller in rolling contact with an upwardly facing, bearing surface of the lower plate and a downwardly facing surface of the upper plate. The lower plate is fixable to a base, while the upper plate is fixable to a superstructure. One or both bearing surfaces are sloped to form a central trough at which the cylindrical roller resides under normal weight of the superstructure, and toward which the roller is biased when displacement between the plates occurs. A pair of sidewall members are fixed to the lower plate to withstand strong forces directed laterally with respect to the isolation axis along which rolling displacement occurs, and a pair of sliding guides carried one at each end of the roller provide dry frictional damping as they engage an inner wall surface of a corresponding sidewall member.

Abstract: A seismic isolation bearing assembly includes a frame unit including upper and lower frames and defining a plurality of upper and lower sub-frames, and a plurality of bearing units, each of which is mounted in a mounting cell defined by a respective one of the upper sub-frames and a respective one of the lower sub-frames, and each of which includes spaced apart upper and lower load plates and a bearing interposed between and in sliding contact with the upper and lower load plates. The upper load plate is secured to the respective one of the upper sub-frames. The lower load plate is secured to the respective one of the lower sub-frames.

Abstract: A fluid filtration assembly (10) operable to provide both return-side and supply-side filtration, as, for example, of a fluid entering and leaving a sump (14) as it circulates in a vehicle transmission (12). The fluid filtration assembly (10) broadly comprises a return-side filter (18) and a supply-side filter (20). The return-side filter (18) includes a filter media (33) operable to filter relatively small particles. Fluid flow through the return-side filter (18) may be accomplished using any of three described alternative embodiments, including upflow, downflow, and direct feed. The supply-side filter (20) includes a filter media (42) for filtering needed fluid as it is drawn back into circulation. The supply-side filter media (42) is a low restriction filter media operable to filter only relatively large particles, thereby decreasing bottle-neck effects and minimizing pressure drops.

Abstract: A seismic isolation bearing comprises a lower plate, an upper plate, and a cylindrical roller in rolling contact with an upwardly facing bearing surface of the lower plate and a downwardly facing surface of the upper plate. The lower plate is fixable to a base, while the upper plate is fixable to a superstructure, for example a bridge deck. One or both bearing surfaces are sloped to form a central trough at which the cylindrical roller resides under normal weight of the superstructure, and toward which the roller is biased when relative displacement between the lower and upper plates occurs to provide a constant restoring force. A pair of sidewall members are fixed to the lower plate to withstand strong forces directed laterally with respect to the isolation axis along which rolling displacement occurs, and a pair of sliding guides carried one at each end of the roller provide dry frictional damping as they engage an inner wall surface of a corresponding sidewall member.

Abstract: A friction damper comprises a channel member including at least one friction channel and a wedge member including at least one friction wedge received by a corresponding friction channel for sliding motion along the channel relative to the channel member. Each friction channel has a pair of internal sidewalls connected by an internal transverse wall, wherein at least one of the pair of sidewalls forms an obtuse angle with the transverse wall. In a preferred construction, the sidewalls are symmetrically convergent as they approach the connecting transverse wall. Each friction wedge includes a pair of external sidewalls parallel to the internal sidewalls of the channel, wherein the external sidewalls of the friction wedge are movable into surface-to-surface engagement with the internal sidewalls of the friction channel by adjusting the depth of receipt of the friction wedge in the friction channel.

Abstract: A seismic isolation bearing comprises a lower plate, an upper plate, and a cylindrical roller in rolling contact with an upwardly facing bearing surface of the lower plate and a downwardly facing surface of the upper plate. The lower plate is fixable to a base, while the upper plate is fixable to a superstructure, for example a bridge deck. One or both bearing surfaces are sloped to form a central trough at which the cylindrical roller resides under normal weight of the superstructure, and toward which the roller is biased when relative displacement between the lower and upper plates occurs to provide a constant restoring force. A pair of sidewall members are fixed to the lower plate to withstand strong forces directed laterally with respect to the isolation axis along which rolling displacement occurs, and a pair of sliding guides carried one at each end of the roller provide dry frictional damping as they engage an inner wall surface of a corresponding sidewall member.

Abstract: A fluid filtration assembly (10) operable to provide both return-side and supply-side filtration, as, for example, of a fluid entering and leaving a sump (14) as it circulates in a vehicle transmission (12). The fluid filtration assembly (10) broadly comprises a return-side filter (18) and a supply-side filter (20). The return-side filter (18) includes a filter media (33) operable to filter relatively small particles. Fluid flow through the return-side filter (18) maybe accomplished using any of three described alternative embodiments, including upflow, downflow, and direct feed. The supply-side filter (20) includes a filter media (42) for filtering needed fluid as it is drawn back into circulation. The supply-side filter media (42) is a low restriction filter media operable to filter only relatively large particles, thereby decreasing bottleneck effects and minimizing pressure drops.

Abstract: A method for generating authentication identification symbols, such as numbers, letters, etc., generates sequences of unpredictable symbols which are employed by vendors of various types of goods to authenticate the goods. Using special mathematical functions, an agent generates a first unpredictable subset of symbols to be supplied to a vendor for marking the vendor's goods. The subset is unpredictable in that knowledge of one or more symbols in the subset cannot be employed to predict other symbols in the subset. Preferably, the vendor then selects another subset of symbols from the first subset, and the symbols in this sub-subset are employed for marking the vendor's goods. The unpredictability of the symbol sequences prevents a counterfeiter from being able to predict other symbols in the sequence. In addition, the vendor's use of a sub-subset of symbols prevents the agent from knowing which of the original subset of symbols the vendor is employing to mark the goods.

Abstract: The present invention is a seismic accelerometer to measure and record low frequencies and large dynamic measurement ranges. The accelerometer comprises at least one directional piezoelectric sensing element and an integrated circuit. Each directional piezoelectric sensing element senses inertial forces applied to the accelerometer from a particular direction, X, Y or Z, and generates a force voltage signal in response to the inertial forces applied to the accelerometer. The sensitivity of each directional piezoelectric sensing element is in direct proportion to the sensitivity of the integrated circuit and the mass of a first mass. The integrated circuit system receives the force voltage signal from each directional piezoelectric sensing element and generates an output signal for each direction.

Abstract: A method and apparatus for structural deflection control, as well as associated sequential controls that are based on new control laws. The apparatus of this invention is of relatively low cost and performs better than prior art devices. The essence of the invention is to adjust the dynamic parameters (mass, damping, stiffness coefficients of the structure and/or input forcing coefficients) adaptive to input dynamic loads, by using the new devices and the suggested control laws. In so doing, the structure performs an adaptive function to effectively counter the effects induced by multi-directional external excitations. The required control power can be nil, or many times lower than prior art active control devices, and the effectiveness can be equivalent or even better than the current state-of-the-art active controls. The devices used by the apparatus of this invention can readily be manufactured for immediate application in structures, buildings and contents, and other constructed facilities.

Abstract: A centrifugal oil separator assembly (36) mounts to the front cover (26) of an internal combustion engine (20) adjacent to the engine crankcase (34). The oil separator assembly (36) includes a first rotational member (42) that has turbo fan blades (52) and a second rotational member (56) that has centrifugal fan blades (60) and air seal grooves (66). A driven pulley (44) causes the oil separator assembly ( 36 ) to rotate. As it rotates, blowby gas is drawn through the centrifugal fan blades (60) where oil is separated from the gas and then through the turbo fan blades (52) which pushes the filtered gas into an air flow passage (28, 30) leading to the air intake system (31).