Patents by Inventor George C. Morton

George C. Morton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aminothiazole compounds and methods using same
    Patent number: 11787794
    Abstract: The present invention includes novel aminothiazole compounds of formula (I), which are useful in preventing or treating cancer in a subject in need thereof.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: October 17, 2023
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Jean-Pierre J. Issa, Hanghang Zhang, Magid Abou-Gharbia, Wayne E. Childers, George C. Morton
  • (S)-2-AMINO-6-((3-AMINOPROPYL)AMINO)HEXANOIC ACID (APL) FOR USE IN THE TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS (NASH), LIVER INFLAMMATION, HEPATOCELLULAR BALLOONING, LIVER FIBROSIS AND STEATOSIS
    Publication number: 20230172886
    Abstract: (S)-2-amino-6-((3-aminopropyl)amino)hexanoic acid (APL) for use in the treatment of non-alcoholic steatohepatitis (NASH), liver inflammation, hepatocellular ballooning, liver fibrosis and steatosis.
    Type: Application
    Filed: April 23, 2021
    Publication date: June 8, 2023
    Inventors: Salim MERALI, Wayne E. CHILDERS, Carlos BARRERO, George C. MORTON, Mario Cesar RICO
  • Compositions and methods for treatment of insulin resistance
    Patent number: 11596615
    Abstract: Compounds of Formula (I), and pharmaceutically effective salts thereof; wherein R1-R14, m, n, o, p, q and r are as defined herein, are provided for treatment of for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: March 7, 2023
    Assignee: TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Salim Merali, Carlos A. Barrero, Wayne E. Childers, George C. Morton
  • Bridged bicycloalkyl-substituted aminothiazoles and their methods of use
    Patent number: 10941126
    Abstract: The present invention includes novel bridged bicycloalkyl-substituted aminothiazole compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: March 9, 2021
    Assignee: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Wayne C. Childers, Magid A. Abou-Gharbia, George C. Morton, Jean-Pierre J. Issa, Hanghang Zhang
  • COMPOSITIONS AND METHODS FOR TREATMENT OF INSULIN RESISTANCE
    Publication number: 20210052532
    Abstract: In certain embodiments, this disclosure relates to methods of treating or preventing type 2 diabetes, pre-diabetes and conditions characterized by an increase in the levels of A1C, glucose, insulin, homeostasis model of assessment of insulin resistance HOMA-IR), oxidative stress in adipose tissue, and earbonvlation of GLUT4 comprising administering an effective amount of a compound of Formula I-III as described herein, to a subject in need thereof.
    Type: Application
    Filed: March 7, 2019
    Publication date: February 25, 2021
    Applicant: Temple University - Of The Commonwealth System Of Higher Education
    Inventors: Salim MERALI, Carlos A. BARRERO, Wayne E. CHILDERS, George C. MORTON
  • COMPOSITIONS AND METHODS FOR TREATMENT OF INSULIN RESISTANCE
    Publication number: 20210046030
    Abstract: Compounds of Formula (I), and pharmaceutically effective salts thereof; wherein R1-R14, m, n, o, p, q and r are as defined herein, are provided for treatment of for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.
    Type: Application
    Filed: July 17, 2020
    Publication date: February 18, 2021
    Inventors: Salim Merali, Carlos A. Barrero, Wayne e. Childers, George c. Morton
  • COMPOSITIONS AND METHODS FOR TREATMENT OF INSULIN RESISTANCE
    Publication number: 20200392075
    Abstract: Compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein X is selected from the group consisting of —O—, —S—, —NR14—O—, —O—NR14—, —NR14—NR15— and —S—S—; R1-R15, m, n, o, p, q and r are as defined herein, are provided for treatment for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.
    Type: Application
    Filed: March 7, 2019
    Publication date: December 17, 2020
    Inventors: Salim Merali, Carlos A. Barrero, Wayne E. Childers, George C. Morton
  • Beta lactams as modulators of glutamate uptake and methods for use thereof
    Patent number: 10759750
    Abstract: Pharmaceutical compositions of the invention comprise compounds, compositions, methods useful for the treatment of drug addiction, drug withdrawal, and diseases or conditions that involve dysregulation of glutamate homeostasis in its etiology.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: September 1, 2020
    Assignee: Temple University—Of The Commonwealth System Of Higher Education
    Inventors: Magid A. Abou-Gharbia, Benjamin E. Blass, Wayne E. Childers, Mercy Ramanjulu, George C. Morton
  • Compositions and methods for treatment of insulin resistance
    Patent number: 10729670
    Abstract: Compounds of Formula (I), and pharmaceutically effective salts thereof; wherein R1-R14, m, n, o, p, q and r are as defined herein, are provided for treatment of for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: August 4, 2020
    Assignee: Temple University—Of The Commonwealth Systems Of Higher Education
    Inventors: Salim Merali, Carlos A. Barrero, Wayne E. Childers, George C. Morton
  • Novel Aminothiazole Compounds and Methods Using Same
    Publication number: 20200071314
    Abstract: The present invention includes novel aminothiazole compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.
    Type: Application
    Filed: November 7, 2019
    Publication date: March 5, 2020
    Inventors: Jean-Pierre J. Issa, Hanghang Zhang, Magid Abou-Gharbia, Wayne E. Childers, George C. Morton
  • Aminothiazole compounds and methods using same
    Patent number: 10513516
    Abstract: The present invention includes novel aminothiazole compounds of formula (I) useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: December 24, 2019
    Assignee: Temple University—Of The Commonwealth System of Higher Education
    Inventors: Jean-Pierre J. Issa, Hanghang Zhang, Magid Abu-Gharbia, Wayne E. Childers, George C. Morton
  • Novel Bridged Bicycloalkyl-Substituted Aminothiazoles and Their Methods of Use
    Publication number: 20190352272
    Abstract: The present invention includes novel bridged bicycloalkyl-substituted aminothiazole compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.
    Type: Application
    Filed: January 19, 2018
    Publication date: November 21, 2019
    Inventors: Wayne C. Childers, Magid A. Abou-Gharbia, George C. Morton, Jean-Pierre J. Issa, Hanghang Zhang
  • COMPOSITIONS AND METHODS FOR TREATMENT OF INSULIN RESISTANCE
    Publication number: 20190192462
    Abstract: Compounds of Formula (I), and pharmaceutically effective salts thereof; wherein R1-R14, m, n, o, p, q and r are as defined herein, are provided for treatment of for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.
    Type: Application
    Filed: September 7, 2017
    Publication date: June 27, 2019
    Inventors: Salim Merali, Carlos A. Barrero, Wayne E. Childers, George C. Morton
  • Novel Beta Lactams as Modulators of Glutamate Uptake and Methods for Use Thereof
    Publication number: 20190127323
    Abstract: Pharmaceutical compositions of the invention comprise compounds, compositions, methods useful for the treatment of drug addiction, drug withdrawal, and diseases or conditions that involve dysregulation of glutamate homeostasis in its etiology.
    Type: Application
    Filed: April 27, 2017
    Publication date: May 2, 2019
    Inventors: Magid A. Abou-Gharbia, Benjamin E. Blass, Wayne E. Childers, Mercy Ramanjalu, George C. Morton
  • Novel Aminothiazole Compounds and Methods Using Same
    Publication number: 20180215750
    Abstract: The present invention includes novel aminothiazole compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.
    Type: Application
    Filed: July 21, 2016
    Publication date: August 2, 2018
    Inventors: Jean-Pierre J. Issa, Hanghang Zhang, Magid Abu-Gharbia, Wayne E. Childers, George C. Morton
  • Tricyclic Derivatives and Their Pharmaceutical Use and Compositions
    Publication number: 20150368257
    Abstract: This application relates to tricyclic compounds of Formula I: including all stereoisomeric forms, all mixtures of stereoisomeric forms, and salts of these compounds. This application also relates to compositions comprising compounds of Formula I, stereoisomeric forms, all mixtures of stereoisomeric forms, and salts thereof and uses therefor.
    Type: Application
    Filed: August 21, 2015
    Publication date: December 24, 2015
    Inventors: Shawn P. Allwein, George C. Morton, Gerard C. Rosse, Yi Wang
  • Tricyclic derivatives and their pharmaceutical use and compositions
    Patent number: 9115147
    Abstract: This application relates to tricyclic compounds of Formula I: including all stereoisomeric forms, all mixtures of stereoisomeric forms, and salts of these compounds. This application also relates to compositions comprising compounds of Formula I, stereoisomeric forms, all mixtures of stereoisomeric forms, and salts thereof and uses therefor.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: August 25, 2015
    Assignee: Cephalon, Inc.
    Inventors: Shawn P. Allwein, George C. Morton, Gerard C. Rosse, Yi Wang
  • Tricyclic derivatives and their pharmaceutical use and compositions
    Patent number: 8765779
    Abstract: This application relates to tricyclic compounds of Formula I: including all stereoisomers, mixtures of stereoisomers, and salts thereof. This application also relates to compositions comprising compounds of Formula I and uses therefore.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: July 1, 2014
    Assignee: Cephalon, Inc.
    Inventors: Edward R. Bacon, Thomas R. Bailey, Derek D. Dunn, Greg A. Hostetler, Robert J. McHugh, George C. Morton, Gerard C. Rosse, Joseph M. Salvino, Babu G. Sundar, Rabindranath Tripathy
  • Tricyclic Derivatives and Their Pharmaceutical Use and Compositions
    Publication number: 20120295882
    Abstract: This application relates to tricyclic compounds of Formula I: including all stereoisomers, mixtures of stereoisomers, and salts thereof. This application also relates to compositions comprising compounds of Formula I and uses therefore.
    Type: Application
    Filed: June 21, 2012
    Publication date: November 22, 2012
    Applicant: Cephalon, Inc.
    Inventors: Edward R. Bacon, Thomas R. Bailey, Derek D. Dunn, Greg A. Hostetler, Robert J. McHugh, George C. Morton, Gerard C. Rosse, Joseph M. Salvino, Babu G. Sundar, Rabindranath Tripathy
  • Tricyclic Derivatives and Their Pharmaceutical Use and Compositions
    Publication number: 20120277186
    Abstract: This application relates to tricyclic compounds of Formula I: including all stereoisomeric forms, all mixtures of stereoisomeric forms, and salts of these compounds. This application also relates to compositions comprising compounds of Formula I, stereoisomeric forms, all mixtures of stereoisomeric forms, and salts thereof and uses therefor.
    Type: Application
    Filed: June 21, 2012
    Publication date: November 1, 2012
    Applicant: Cephalon, Inc.
    Inventors: Shawn P. Allwein, George C. Morton, Gerard C. Rosse, Yi Wang