Abstract: The method, system, and a computer program product are directed to dynamic batching of messages for network optimization, such as Quality of Service (QoS) optimization. The edge server dynamically decides which messages can be processed locally, which messages should be batched and transmitted asynchronously as a batch, and which messages should be processed synchronously. Such message processing improves the QoS of a network.

Abstract: A coffee machine for wirelessly driving a coffee filter cup to rotate relates to a coffee brewing device. The coffee machine comprises a machine body and a cup holder, wherein an annular frame is provided on the cup holder, an annular bracket for supporting a coffee filter cup is provided in the annular frame, and the annular bracket is rotatable relative to the annular frame; the machine body is provided with a charging coil, the cup holder is provided with a power receiving coil, and the power receiving coil is provided corresponding to the charging coil; a motor is provided on the cup holder, and the motor is capable of obtaining power through the power receiving coil to drive the annular bracket to rotate, thereby driving the coffee filter cup to rotate.

Abstract: A system to augment the collected odometer data points with more precise location data which provides an indication of a location of a vehicle associated with the odometer at a given time, such as Global Positioning System (GPS) GPS data points. Additionally, the GPS data points may be collected at a higher sampling rate than the odometer data points, thus providing a more precise indication of a distance traveled by a vehicle at any given time.

Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: An example method includes receiving a selection of an item; retrieving a user interaction history and a user profile; determining a pattern of user behavior based on the user interaction history and on the user profile; receiving a set of active promotions for the third party; receiving a set of donation-receiving organizations; receiving, from an investment provider, a set of investments; determining an amount of savings based on a comparison of the selected item to the set of active promotions; determining at least one donation-receiving organization and at least one investment based on the pattern of user behavior; and presenting, on a GUI, an interactive element that enables a user to complete a transaction involving the selected item and direct the amount of savings to the at least one determined donation-receiving organization or to the at least one determined investment.

Abstract: An example method includes receiving a request for a transaction; associating the request with a user; receiving, from the user, identification information; retrieving, from a database, first stored authentication information associated with the user; retrieving, from a distributed ledger, second stored authentication information associated with the user; and determining that the received authentication information matches the first stored authentication details and the second stored authentication details and, in response, outputting, by the computing system, a proof of authentication to enable the transaction.

Abstract: This invention is useful for determining the permeability of a geological formation using 1H NMR diffusion measurements acquired in the laboratory and using downhole 1H NMR well logging. The current technology for obtaining formation permeability downhole using NMR is not adequate for low-permeability, unconventional source rock formations with high organic content. This new method uses laboratory 1H NMR diffusion measurements for creating continuous downhole well logs of the mobile-hydrocarbon permeability of the hydrocarbon-filled pore space of downhole geological formations.

Abstract: A treatment probe for treating an eye of a patient includes an elongate body that defines a handle and a treatment fiber that is housed within the elongate body. The treatment fiber is configured to deliver treatment light energy to the eye. A contact member is disposed on an end of the elongate body. The contact member has a contact surface for positioning on a surface of the eye, two side edges that are positioned on opposite sides of the contact surface, and a fluid channel. The contact surface conforms to the shape of the eye's sclera and the two side edges are shaped to direct fluid that is present on the surface of the eye toward the fluid channel when the contact member is moved laterally across the surface of the eye. The fluid aggregates within the fluid channel and contacts a distal end of the treatment fiber.

Abstract: Provided are compounds of Formula (I?): or pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined herein; and methods for their use and production.

Abstract: The following invention is used for determining the relative permeability of a fluid in a rock for three different phases: water, oil, and gas, in both conventional and unconventional formations. The permeability of a phase describes how much it can flow in porous media given a pressure gradient and is useful in evaluating reservoir quality and productivity. The following invention is a method to determine the three-phase relative permeabilities in both conventional and unconventional formations using NMR restricted diffusion measurements on core with NMR-active nuclei, combined with centrifugation of the core. In addition, the tortuosity, pore size (surface-to-volume ratio), fluid-filled porosity, and permeability is determined for each of the three phases in a rock.

Abstract: Systems and techniques for providing security data points from an electronic message are presented. A system can determine a first interne protocol (IP) address of a computing device in response to a user of the computing device opening an email sent to an email address corresponding to a particular electronic account of the user, the email comprising an IP address tracking mechanism. The system can also compare the first IP address with one or more second IP addresses corresponding to one or more electronic accesses of the particular electronic account. Furthermore, the system can determine if an account access anomaly exists in regard to the particular electronic account based on a result of the comparing. The system can also implement a security measure impacting an ability of the particular electronic account to conduct one or more transactions in response to the account access anomaly existing for the particular electronic account.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Systems, apparatuses, and methods for scanning a shopping space. The system pace comprises a locomotion system of a motorized unit, a camera system, and a central computer system. The central computer system is configured to receive motorized unit location information from the locomotion system, the motorized unit location information comprises a plurality of sets of coordinates each associated with a timestamp, receive item identifier instances from the camera system, wherein each item identifier instance is associated with a timestamp, and determine a location for each item identifier instance based on the timestamps associated of the item identifier instances and the timestamps associated with the plurality of sets of coordinates of the motorized unit location information.

Abstract: There are provided systems and methods for streamlined and privacy protected data flows for entity onboarding with online data platforms. An online transaction processor or other service provider may provide computing services and platforms to entities including merchants for electronic transaction processing and other account services. To onboard entities with the transaction processor, the transaction processor may provide a multistep system that includes allowing entities to specify particular needs of input/output mechanisms, configure interface buttons having a wrapper layer, and submit feedback on error logs. The transaction processor may also provide a masking service to detect, mask, and notify the entity of sensitive data exposures during onboarding and usage of merchant systems. Additionally, the transaction processor may provide a sandbox environment for the entity to test different accounts having different permissions.

Abstract: Provided herein are clonal strains of a vaccinia virus that exhibits enhanced anti-tumor properties and/or reduced immunogenicity, and recombinant vaccinia virus derived from the same. Also provided herein are recombinant oncolytic virus strains that include an inactivating mutation in one or more viral genes, and/or one of more heterologous nucleic acids each encoding one or more heterologous gene products. The viruses, e.g., vaccinia viruses, provided herein, including recombinant vaccinia viruses, can be used as an oncolytic virus therapy, e.g., an oncolytic vaccinia virus therapy, for treating cancer. Also provided herein are pharmaceutical compositions and methods and uses of the viruses, e.g., vaccinia viruses, for treating cancer, as well as nucleic acids encoding the viruses.

Abstract: Techniques are disclosed relating to retaining a log entry in response to detection of a respective triggering event occurring within a computer network. This triggering event may result in a set of processes being performed. A computer system may determine a trace signature for the log entry. This trace signature may track information related to the set of processes. The computer system may compute, using the trace signature, a log retention value for the log entry. This log retention value may be computed using weight factors for ones of the set of processes. The computer system may retain the log entry within a log file according to a retention period that corresponds to the log retention value.

Abstract: A method includes generating, a communication to a user, the communication including content, receiving a user request to serve a first webpage, and determining metadata associated with the request. The method further includes retrieving metadata associated with the communication and determining that the request is from the user according to the metadata associated with the request and according to the metadata associated with the communication. The method further includes transmitting data respective of a second webpage, the second webpage different from the first webpage, in response to determining that the request is from the user, the second webpage associated with the content.

Abstract: Techniques are disclosed for mitigating network-based attacks, brute-force attacks, enumeration account takeover type attacks, and generally attacks that might result in unauthorized access to user accounts, denial-of-service, loss of functionality to users, etc. Authenticating a user at an end-point of a network may occur using an activator. In some instances, an authentication module (e.g. on a server) receives and validates a key activator. If the key activator is valid, the authentication module is activated. After the authentication module is activated, the authentication module may receive and authenticate a security credential, such as a password, that is associated with the user. If the authentication module receives the security credential without being activated, the authentication module may not authenticate the security credential, even if the security credential is a valid credential.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: Techniques are disclosed relating to dynamically routing network traffic between defense layers. For example, in various embodiments, a server system may implement a traffic distribution module that is operable to distribute a particular type of network traffic across multiple different defense layers. The traffic distribution module may receive a first set of requests that have been identified as being indicative of that particular type of network traffic and then route this first set of requests across the different defense layers based on a set of distribution weightage values. In various embodiments, the disclosed techniques include determining an updated set of distribution weightage values based on an effectiveness of the defense layers in mitigating the particular type of network traffic. In such embodiments, the traffic distribution module may then use this updated set of distribution weightage values to route a second set of network traffic across the various defense layers.