Patents by Inventor George Christou

George Christou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11505470
    Abstract: Described herein are compositions and methods relating to molecular cerium-oxide nanoclusters. Described herein are methods of producing cerium-oxide nanoclusters. Described herein are cerium-oxide nanoclusters. Further described herein are cerium-oxide nanoclusters produced by methods as described herein. Methods as described herein can comprise providing a first cerium source, an organic acid, and a solvent; and mixing the cerium source and the organic acid in the presence of a solvent to create a reaction mixture at a temperature and a pressure for a period of time to create a composition of molecular cerium-oxide nanoclusters containing a plurality of molecular cerium-oxide nanoclusters.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: November 22, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: George Christou, Bradley Keith Russell-Webster
  • Publication number: 20220072512
    Abstract: Described herein are compositions and methods relating to molecular cerium-oxide nanoclusters. In an aspect, described herein are methods of synthesizing molecular cerium-oxide nanocluster compositions and compositions thereof. In an aspect, described herein are methods of scavenging reactive oxygen species utilizing molecular cerium-oxide nanoclusters as described herein. Also described herein are pharmaceutical compositions and methods of use. Pharmaceutical compositions as described herein can comprise a therapeutically effective amount of a compound (such as a composition comprising one or more molecular cerium-oxide nanoclusters), or a pharmaceutically acceptable salt of the compound, and a pharmaceutically acceptable carrier. Methods of treating oxidative stress are also described herein, comprising administering pharmaceutical compositions as described herein to a subject in need thereof.
    Type: Application
    Filed: November 17, 2021
    Publication date: March 10, 2022
    Inventors: George CHRISTOU, Kylie J. MITCHELL
  • Patent number: 11207663
    Abstract: Described herein are compositions and methods relating to molecular cerium-oxide nanoclusters. In an aspect, described herein are methods of synthesizing molecular cerium-oxide nanocluster compositions and compositions thereof. In an aspect, described herein are methods of scavenging reactive oxygen species utilizing molecular cerium-oxide nanoclusters as described herein. Also described herein are pharmaceutical compositions and methods of use. Pharmaceutical compositions as described herein can comprise a therapeutically effective amount of a compound (such as a composition comprising one or more molecular cerium-oxide nanoclusters), or a pharmaceutically acceptable salt of the compound, and a pharmaceutically acceptable carrier. Methods of treating oxidative stress are also described herein, comprising administering pharmaceutical compositions as described herein to a subject in need thereof.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: December 28, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: George Christou, Kylie J. Mitchell
  • Publication number: 20210238207
    Abstract: Described herein are compositions and methods relating to molecular cerium-oxide nanoclusters. Described herein are methods of producing cerium-oxide nanoclusters. Described herein are cerium-oxide nanoclusters. Further described herein are cerium-oxide nanoclusters produced by methods as described herein. Methods as described herein can comprise providing a first cerium source, an organic acid, and a solvent; and mixing the cerium source and the organic acid in the presence of a solvent to create a reaction mixture at a temperature and a pressure for a period of time to create a composition of molecular cerium-oxide nanoclusters containing a plurality of molecular cerium-oxide nanoclusters.
    Type: Application
    Filed: May 3, 2019
    Publication date: August 5, 2021
    Inventors: George CHRISTOU, Bradley Keith RUSSELL-WEBSTER
  • Publication number: 20190308884
    Abstract: Described herein are compositions and methods relating to molecular cerium-oxide nanoclusters. In an aspect, described herein are methods of synthesizing molecular cerium-oxide nanocluster compositions and compositions thereof. In an aspect, described herein are methods of scavenging reactive oxygen species utilizing molecular cerium-oxide nanoclusters as described herein. Also described herein are pharmaceutical compositions and methods of use. Pharmaceutical compositions as described herein can comprise a therapeutically effective amount of a compound (such as a composition comprising one or more molecular cerium-oxide nanoclusters), or a pharmaceutically acceptable salt of the compound, and a pharmaceutically acceptable carrier. Methods of treating oxidative stress are also described herein, comprising administering pharmaceutical compositions as described herein to a subject in need thereof.
    Type: Application
    Filed: December 6, 2017
    Publication date: October 10, 2019
    Inventors: George CHRISTOU, Kylie J. MITCHELL
  • Patent number: 9365600
    Abstract: Embodiments of the present disclosure provide for polynuclear manganese cluster compounds, methods of making, methods of use, method of producing hydrogen and oxygen from water, and the like.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: June 14, 2016
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Galia Maayan, George Christou
  • Publication number: 20140042035
    Abstract: Embodiments of the present disclosure provide for polynuclear manganese cluster compounds, methods of making, methods of use, method of producing hydrogen and oxygen from water, and the like.
    Type: Application
    Filed: April 30, 2012
    Publication date: February 13, 2014
    Inventors: Galia Maayan, George Christou