Patents by Inventor GEORGE CLEMENT DOBBINS

GEORGE CLEMENT DOBBINS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multitargeting onocolytic adenovirus, methods of use, and methods of making
    Patent number: 10617729
    Abstract: To increase the therapeutic potential of these oncolytic viruses based on a 24 base pair deletion in the viral E1 A gene (D24), a conditionally replicating adenovirus targeting multiple receptors upregulated on tumors was generated by incorporating an Ad5/3 fiber with a carboxyl terminus RGD ligand. The virus displayed full cytopathic effect in tumor lines assayed at low titers with improved cytotoxicity over Ad5-RGD D24, Ad5/3 D24 and an HSV oncolytic virus. The virus was further engineered to deliver immunotherapeutic agents such as GMCSF while maintaining enhanced heterogenic oncolysis.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: April 14, 2020
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventor: George Clement Dobbins
  • MULTITARGETING ONOCOLYTIC ADENOVIRUS, METHODS OF USE, AND METHODS OF MAKING
    Publication number: 20170368117
    Abstract: To increase the therapeutic potential of these oncolytic viruses based on a 24 base pair deletion in the viral E1 A gene (D24), a conditionally replicating adenovirus targeting multiple receptors upregulated on tumors was generated by incorporating an Ad5/3 fiber with a carboxyl terminus RGD ligand. The virus displayed full cytopathic effect in tumor lines assayed at low titers with improved cytotoxicity over Ad5-RGD D24, Ad5/3 D24 and an HSV oncolytic virus. The virus was further engineered to deliver immunotherapeutic agents such as GMCSF while maintaining enhanced heterogenic oncolysis.
    Type: Application
    Filed: December 21, 2015
    Publication date: December 28, 2017
    Inventor: GEORGE CLEMENT DOBBINS