Patents by Inventor George D. Cimino
George D. Cimino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11474106Abstract: The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after administration of a microdose of therapeutic composition to the patient. The methods provides physicians with a diagnostic tool to segregate cancer patients into differential populations that have a higher or lower chance of responding to a particular therapeutic treatment.Type: GrantFiled: July 7, 2016Date of Patent: October 18, 2022Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Paul Henderson, George D. Cimino, Chong-Xian Pan, Ralph William de Vere White, Maike Zimmermann, Kenneth W. Turteltaub
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Publication number: 20200010910Abstract: The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after administration of a microdose of therapeutic composition to the patient or a sample from the patient. The methods provides physicians with a diagnostic tool to segregate cancer patients into differential populations that have a higher or lower chance of responding to a particular therapeutic treatment.Type: ApplicationFiled: July 10, 2019Publication date: January 9, 2020Inventors: Paul Henderson, George D. Cimino, Maike Zimmermann, Michael A. Malfatti, Kenneth W. Turteltaub, Ralph W. De Vere White, Brian Jonas, Tiffany Scharadin, Chong-Xian Pan
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Publication number: 20180209984Abstract: The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after administration of a microdose of therapeutic composition to the patient. The methods provides physicians with a diagnostic tool to segregate cancer patients into differential populations that have a higher or lower chance of responding to a particular therapeutic treatment.Type: ApplicationFiled: July 7, 2016Publication date: July 26, 2018Inventors: Paul Henderson, George D. Cimino, Chong-Xian Pan, Ralph William de Vere White, Maike Zimmermann, Kenneth W. Turteltaub
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Patent number: 7459695Abstract: Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.Type: GrantFiled: July 27, 2005Date of Patent: December 2, 2008Assignees: Fenwal, Inc., Cerus CorporationInventors: Kathleen A. Hanley, George D. Cimino, Peter R. H. Stark, Wendy M. Power, Paul A. Franzosa, Daniela Homza Stark, David F. Beittel, Peyton S. Metzel
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Patent number: 7433030Abstract: Apparatus (10), systems and methods are disclosed for treating a biological fluid with light. A container (206) of biological fluid is introduced into a fluid treatment chamber (40) where it is contacted with light provided by one or more light sources (60, 70) in proximity to the fluid treatment chamber (40). A light sensing system (650) senses the intensity of illumination of the light. A radiometer (460) may be inserted into fluid treatment chamber (40) to calibrate the light sensing system (650). An electronic control system (600) utilizes an interface circuit board (606) to interface a computer circuit board (602) to a display panel (37), a user interface panel (39, 39a), a relay circuit board (640), light sensors 404 and various other sensors (649). A detector (385) senses agitating movement of a tray (90) that contains biological fluids.Type: GrantFiled: May 31, 2006Date of Patent: October 7, 2008Assignees: Fenwal, Inc., Cerus CorporationInventors: Jeffrey M. Waldo, Walter Page Hatch, George D. Cimino, Peter Stark
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Patent number: 7425304Abstract: Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.Type: GrantFiled: February 13, 2006Date of Patent: September 16, 2008Assignees: Fenwal, Inc., Cerus CorporationInventors: Serge de Gheldere, Mahmood Mohiuddin, Peyton S. Metzel, George D. Cimino, Derek J. Hei, Michael S. Clarke
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Patent number: 7105093Abstract: Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.Type: GrantFiled: October 8, 2002Date of Patent: September 12, 2006Assignees: Baxter International Inc., Cerus CorporationInventors: Serge de Gheldere, Mahmood Mohiuddin, Peyton S. Metzel, George D. Cimino, Derek J. Hei, Michael S. Clarke
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Patent number: 7068361Abstract: Apparatus (10), systems and methods are disclosed for treating a biological fluid with light. A container (206) of biological fluid is introduced into a fluid treatment chamber (40) where it is contacted with light provided by one or more light sources (60, 70) in proximity to the fluid treatment chamber (40). A light sensing system (650) senses the intensity of illumination of the light. A radiometer (460) may be inserted into fluid treatment chamber (40) to calibrate the light sensing system (650). An electronic control system (600) utilizes an interface circuit board (606) to interface a computer circuit board (602) to a display panel (37), a user interface panel (39, 39a), a relay circuit board (640), light sensors 404 and various other sensors (649). A detector (385) senses agitating movement of a tray (90) that contains biological fluids.Type: GrantFiled: October 11, 2002Date of Patent: June 27, 2006Assignees: Baxter International, Cerus CorporationInventors: George D. Cimino, Peter Stark
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Patent number: 7025877Abstract: Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.Type: GrantFiled: June 3, 1999Date of Patent: April 11, 2006Assignees: Baxter International Inc., Cerus CorporationInventors: Serge de Gheldere, Mahmood Mohiuddin, Peyton S. Metzel, George D. Cimino, Derek J. Hei, Michael S. Clarke
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Patent number: 6986867Abstract: Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.Type: GrantFiled: July 29, 2002Date of Patent: January 17, 2006Assignee: Baxter International Inc.Inventors: Kathleen A. Hanley, George D. Cimino, Peter R. H. Stark, Wendy M. Power, Paul A. Franzosa, Daniela Homza Stark, David F. Beittel, Peyton S. Metzel
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Patent number: 6949753Abstract: Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell preparations are inactivated prior to long term storage and transfusion. Inactivation is accomplished using a device having a unique temperature control design.Type: GrantFiled: June 30, 2003Date of Patent: September 27, 2005Assignee: Cerus CorporationInventors: George D. Cimino, Romilly John Simms
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Publication number: 20040021089Abstract: Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell preparations are inactivated prior to long term storage and transfusion. Inactivation is accomplished using a device having a unique temperature control design.Type: ApplicationFiled: June 30, 2003Publication date: February 5, 2004Applicant: Cerus CorporationInventors: George D. Cimino, Romilly John Simms
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Patent number: 6680025Abstract: A device containing a light source, a sample support and a temperature control compartment. The sample support is positioned to support multiple sample vessels for irradiation by the light source. The temperature control compartment maintains the temperature of the sample vessels within a desired range. The light source, sample support and temperature control compartment are all contained within an opaque housing.Type: GrantFiled: September 6, 2002Date of Patent: January 20, 2004Assignee: Cerus CorporationInventors: David Paul Hearst, George D. Cimino, John Eugene Hearst, Stephen T. Isaacs
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Publication number: 20030170141Abstract: A device comprising a light source, a sample support and a temperature control compartment. The sample support is positioned to support multiple sample vessels for irradiation by the light source. The temperature control compartment maintains the temperature of the sample vessels within a desired range. The light source, sample support and temperature control compartment are all contained within an opaque housing.Type: ApplicationFiled: September 6, 2002Publication date: September 11, 2003Applicant: Cerus CorporationInventors: David Paul Hearst, George D. Cimino, John Eugene Hearst, Stephen T. Isaacs
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Publication number: 20030165398Abstract: Apparatus (10), systems and methods are disclosed for treating a biological fluid with light. A container (206) of biological fluid is introduced into a fluid treatment chamber (40) where it is contacted with light provided by one or more light sources (60, 70) in proximity to the fluid treatment chamber (40). A light sensing system (650) senses the intensity of illumination of the light. A radiometer (460) may be inserted into fluid treatment chamber (40) to calibrate the light sensing system (650). An electronic control system (600) utilizes an interface circuit board (606) to interface a computer circuit board (602) to a display panel (37), a user interface panel (39, 39a), a relay circuit board (640), light sensors 404 and various other sensors (649). A detector (385) senses agitating movement of a tray (90) that contains biological fluids.Type: ApplicationFiled: October 11, 2002Publication date: September 4, 2003Inventors: Jeffrey M. Waldo, Walter Page Hatch, George D. Cimino, Peter Stark
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Publication number: 20030146162Abstract: Apparatus, systems and methods are disclosed for treating a biological fluid with light. A disposable fluid processing set including integrally connected containers and tubing and a holder or organizer for receiving at least some of the containers and tubing are disclosed.Type: ApplicationFiled: October 11, 2002Publication date: August 7, 2003Inventors: Peyton S. Metzel, Daniel F. Bischof, Joseph S. Moore, Yuanpang Samuel Ding, Robert E. Herman, Veronique Mayaudon, Gregory Soudant, Daniel Lecour, Yvon Briere, George D. Cimino, Derek J. Hei, James Laird, Mahmood Mohiuddin
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Patent number: 6586749Abstract: Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell preparations are inactivated prior to long term storage and transfusion. Inactivation is accomplished using a device having a unique temperature control design.Type: GrantFiled: June 25, 2002Date of Patent: July 1, 2003Assignee: Cerus CorporationInventors: George D. Cimino, Romilly John Simms
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Patent number: 6565802Abstract: Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.Type: GrantFiled: June 3, 1999Date of Patent: May 20, 2003Assignees: Baxter International Inc., Cerus CorporationInventors: Kathleen A. Hanley, George D. Cimino, Peter R. H. Stark, Wendy M. Power, Paul A. Franzosa, Daniela Homza Stark, David F. Beittel, Peyton S. Metzel
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Publication number: 20030085173Abstract: Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.Type: ApplicationFiled: October 8, 2002Publication date: May 8, 2003Inventors: Serge deGheldere, Mahmood Mohiuddin, Peyton S. Metzel, George D. Cimino, Derek J. Hei, Michael S. Clarke
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Publication number: 20030062483Abstract: Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell preparations are inactivated prior to long term storage and transfusion. Inactivation is accomplished using a device having a unique temperature control design.Type: ApplicationFiled: June 25, 2002Publication date: April 3, 2003Applicant: Cerus CorporationInventors: George D. Cimino, Romilly John Simms