Patents by Inventor George D. Hartman

George D. Hartman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HEPATITIS B ANTIVIRAL AGENTS
    Publication number: 20150259324
    Abstract: The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
    Type: Application
    Filed: June 2, 2015
    Publication date: September 17, 2015
    Inventors: George D. Hartman, Osvaldo A. Flores
  • Azepane derivatives and methods of treating hepatitis B infections
    Patent number: 9115113
    Abstract: Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: August 25, 2015
    Assignee: Novira Therapeutics, Inc.
    Inventor: George D Hartman
  • AZEPANE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
    Publication number: 20150225355
    Abstract: Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
    Type: Application
    Filed: April 23, 2015
    Publication date: August 13, 2015
    Inventor: George D. Hartman
  • COMBINATION THERAPY FOR TREATMENT OF HBV INFECTIONS
    Publication number: 20150216938
    Abstract: Provided herein is a combination therapy comprising a compound of Formula I and peginterferon alfa-2a, or another interferon analog. The combination therapy is useful for the treatment of HBV infection. Also provided herein are compositions comprising a compound of Formula I and peginterferon alfa-2a, or another interferon analog.
    Type: Application
    Filed: February 5, 2015
    Publication date: August 6, 2015
    Inventor: George D. Hartman
  • AZEPANE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
    Publication number: 20150197533
    Abstract: Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
    Type: Application
    Filed: January 15, 2015
    Publication date: July 16, 2015
    Inventors: George D. Hartman, Scott Kuduk
  • AZEPANE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
    Publication number: 20150197493
    Abstract: Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
    Type: Application
    Filed: October 10, 2014
    Publication date: July 16, 2015
    Inventor: George D. Hartman
  • Hepatitis B antiviral agents
    Patent number: 9066932
    Abstract: The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: June 30, 2015
    Assignee: Novira Therapeutics, Inc.
    Inventors: George D. Hartman, Osvaldo A. Flores
  • HEPATITIS B ANTIVIRAL AGENTS
    Publication number: 20150174115
    Abstract: Provided herein are compounds useful for the treatment of HBV infection in man.
    Type: Application
    Filed: March 9, 2015
    Publication date: June 25, 2015
    Inventor: George D. Hartman
  • Hepatitis B antiviral agents
    Patent number: 9061008
    Abstract: The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: June 23, 2015
    Assignee: Novira Therapeutics, Inc.
    Inventors: George D. Hartman, Osvaldo A. Flores
  • Hepatitis B Antiviral Agents
    Publication number: 20150152073
    Abstract: The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
    Type: Application
    Filed: October 17, 2014
    Publication date: June 4, 2015
    Inventors: George D. Hartman, Osvaldo A. Flores
  • AZEPANE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
    Publication number: 20150132258
    Abstract: Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
    Type: Application
    Filed: November 14, 2014
    Publication date: May 14, 2015
    Inventor: George D. Hartman
  • Hepatitis B antiviral agents
    Patent number: 8993771
    Abstract: Provided herein are compounds useful for the treatment of HBV infection in man.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: March 31, 2015
    Assignee: Novira Therapeutics, Inc.
    Inventor: George D. Hartman
  • HEPATITIS B ANTIVIRAL AGENTS
    Publication number: 20140275167
    Abstract: Provided herein are compounds useful for the treatment of HBV infection in man.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Inventor: George D. Hartman
  • HEPATITIS B ANTIVIRAL AGENTS
    Publication number: 20140179665
    Abstract: The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
    Type: Application
    Filed: December 9, 2013
    Publication date: June 26, 2014
    Inventors: George D. Hartman, Osvaldo A. Flores
  • HEPATITIS B ANTIVIRAL AGENTS
    Publication number: 20140178337
    Abstract: The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
    Type: Application
    Filed: December 19, 2013
    Publication date: June 26, 2014
    Inventors: George D. Hartman, Osvaldo A. Flores
  • Hepatitis B antiviral agents
    Patent number: 8629274
    Abstract: The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: January 14, 2014
    Assignee: Novira Therapeutics, Inc.
    Inventors: George D. Hartman, Osvaldo A. Flores
  • HEPATITIS B ANTIVIRAL AGENTS
    Publication number: 20130251673
    Abstract: The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
    Type: Application
    Filed: December 21, 2012
    Publication date: September 26, 2013
    Applicant: Novira Therapeutics, INC.
    Inventors: George D. HARTMAN, Osvaldo A. FLORES
  • Novel Lipid Nanoparticles and Novel Components for Delivery of Nucleic Acids
    Publication number: 20110224447
    Abstract: The instant invention provides for novel lipid nanoparticles and novel lipid nanoparticle components (specifically cationic lipids) that are useful for the delivery of nucleic acids, specifically siRNA, for therapeutic purposes.
    Type: Application
    Filed: August 11, 2009
    Publication date: September 15, 2011
    Inventors: Keith A. Bowman, James P. Guare, JR., George D. Hartman, Rubina G. Parmar, Chandra Vargeese, Weimin Wang, Ye Zhang
  • Heteroaryl piperidine glycine transporter inhibitors
    Patent number: 7825135
    Abstract: The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.
    Type: Grant
    Filed: March 23, 2005
    Date of Patent: November 2, 2010
    Assignees: Merck Sharp & Dohme Limited, Merck Sharp & Dohme Corp.
    Inventors: Wesley Blackaby, Mark E. Duggan, David Hallett, George D. Hartman, Andrew S. Jennings, William H. Leister, Richard T. Lewis, Craig W. Lindsley, Elizabeth Naylor, Leslie J. Street, Yi Wang, David D. Wisnoski, Scott E. Wolkenberg, Zhijian Zhao
  • Mitotic kinesin inhibitors
    Patent number: 7745639
    Abstract: The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
    Type: Grant
    Filed: March 4, 2003
    Date of Patent: June 29, 2010
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme Corp.
    Inventors: Michael J. Breslin, Paul J. Coleman, Christopher D. Cox, J. Christopher Culberson, George D. Hartman, Brenda J. Mariano, Maricel Torrent