Patents by Inventor George Digenis

George Digenis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CO-SOLVENT COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF DANTROLENE THERAPEUTIC AGENTS
    Publication number: 20110160261
    Abstract: The present invention provides for methods of using tert-butyl alcohol (TBA) co-solvent systems in the formulation and production of a pharmaceutical agent with low solubility. The present invention also provides for pharmaceutical compositions made using the novel co-solvent system. In one embodiment, the invention provides for a method of making dantrolene sodium (DS) formulation for intravenous use (DS-IV). This instantaneous reconstitution of the DS-IV product constitutes a significant improvement in the pharmacotherapy of patients undergoing malignant hyperthermia during surgery.
    Type: Application
    Filed: September 5, 2008
    Publication date: June 30, 2011
    Applicant: US WorldMeds, LLC
    Inventors: Ahmad Malkawi, Abeer Al-Ghananeem, Patrick DeLuca, George Digenis
  • LOFEXIDINE ENANTIOMERS FOR USE AS A TREATMENT FOR CNS DISEASE AND PATHOLOGIES AND ITS CHIRAL SYNTHESIS
    Publication number: 20110015246
    Abstract: The invention relates to methods for treatment of CNS disease and pathologies using non-racemic mixtures of lofexidine enantiomers. The invention also relates to processes for the manufacture of chirally pure enantiomers of lofexidine.
    Type: Application
    Filed: March 14, 2006
    Publication date: January 20, 2011
    Applicant: Agean LLC
    Inventors: George Digenis, Peter Crooks, Abeer Al-Ghananeem
  • CO-SOLVENT COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF DANTROLENE THERAPUTIC AGENTS
    Publication number: 20110015243
    Abstract: The present invention provides for methods of using tert-butyl alcohol (TBA) co-solvent systems in the formulation and production of a pharmaceutical agent with low solubility. The present invention also provides for pharmaceutical compositions made using the novel co-solvent system. In one embodiment, the invention provides for a method of making dantrolene sodium (DS) formulation for intravenous use (DS-IV). This instantaneous reconstitution of the DS-IV product constitutes a significant improvement in the pharmacotherapy of patients undergoing malignant hyperthermia during surgery.
    Type: Application
    Filed: September 5, 2008
    Publication date: January 20, 2011
    Applicant: US WorldMeds, LLC
    Inventors: Ahmad Malkawi, Abeer Al-Ghananeem, Patrick DeLuca, George Digenis
  • Lofexidine enantiomers for use as a treatment for CNS disease and pathologies and its chiral synthesis
    Publication number: 20080319041
    Abstract: The invention relates to methods for treatment of CNS disease and pathologies using non-racemic mixtures of lofexidine enantiomers. The invention also relates to processes for the manufacture of chirally pure enantiomers of lofexidine.
    Type: Application
    Filed: March 14, 2006
    Publication date: December 25, 2008
    Inventors: George Digenis, Peter A. Crooks, Abeer Al-Ghananeem
  • Iodo-nonoxynol-9-derivatives and methods for their use
    Publication number: 20010036965
    Abstract: Mono- and di-iodinated nonoxynol-9-derivatives and methods for their use are disclosed.
    Type: Application
    Filed: April 3, 2001
    Publication date: November 1, 2001
    Applicant: The Medical College of Hampton Roads, Eastern Virginia Medical School
    Inventors: George Digenis, Philip Fowler, Kazuya Matsumoto, Gustavo Doncel
  • Iodo-nonoxynol-9-derivatives and methods for their use
    Patent number: 6281251
    Abstract: Mono- and di-iodinated nonoxynol-9-derivatives and methods for their use are disclosed.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: August 28, 2001
    Assignees: University of Kentucky Research Foundation, The Medical College of Hampton Roads, Eastern Virginia Medical School
    Inventors: George Digenis, Philip Fowler, Kazuya Matsumoto, Gustavo Doncel