Patents by Inventor George E. Davis
George E. Davis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240122934Abstract: Compositions and methods of treatment for inhibiting capillary tube regression and/or lymphatic tube regression are described, as well as factors and signaling pathways that control the regression of capillary tube networks. Capillary tube regression and/or lymphatic tube regression may be implicated in ischemia, infarction, hypertension, diabetes, malignant cancer, neurodegenerative disease, wound repair response, atherosclerosis, pro-inflammatory disease, pro-thrombotic disease, viral infection (e.g., influenza or SARS-CoV-2), bacterial infection.Type: ApplicationFiled: October 16, 2020Publication date: April 18, 2024Inventors: George E. Davis, Gretchen Margaret Koller
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Patent number: 10913737Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo[1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.Type: GrantFiled: February 5, 2018Date of Patent: February 9, 2021Assignee: UNIVERSITY OF NOTRE DAME DU LACInventors: Marvin J. Miller, Garrett C. Moraski, Lowell D. Markley, George E. Davis
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Publication number: 20180354944Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo [1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.Type: ApplicationFiled: February 5, 2018Publication date: December 13, 2018Applicant: UNIVERSITY OF NOTRE DAME DU LACInventors: Marvin J. MILLER, Garrett C. MORASKI, Lowell D. MARKLEY, George E. DAVIS
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Patent number: 9908876Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo[1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.Type: GrantFiled: February 29, 2016Date of Patent: March 6, 2018Assignee: UNIVERSITY OF NOTRE DAME DU LACInventors: Marvin J. Miller, Garrett C. Moraski, Lowell D. Markley, George E. Davis
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Publication number: 20160318925Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo[1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.Type: ApplicationFiled: February 29, 2016Publication date: November 3, 2016Applicant: UNIVERSITY OF NOTRE DAME DU LACInventors: Marvin J. MILLER, Garrett C. MORASKI, Lowell D. MARKLEY, George E. DAVIS
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Patent number: 9309238Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo[1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.Type: GrantFiled: November 5, 2010Date of Patent: April 12, 2016Assignee: UNIVERSITY OF NOTRE DAME DU LACInventors: Marvin J. Miller, Garrett C. Moraski, Lowell D. Markley, George E. Davis
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Patent number: 9174970Abstract: This present disclosure is related to the field of 5-fluoro pyrimidines and their derivatives and to the use of these compounds as fungicides.Type: GrantFiled: January 22, 2009Date of Patent: November 3, 2015Assignee: Dow AgroSciences LLCInventors: Zoltan L. Benko, Timothy Boebel, Nneka T. Breaux, Kristy Bryan, George E. Davis, Jeffrey B. Epp, Beth Lorsbach, Timothy P. Martin, Kevin G. Meyer, Bassam S. Nader, W. John Owen, Mark A. Pobanz, James M. Ruiz, Frisby D. Smith, Michael T. Sullenberger, Jeffery D. Webster, Chenglin Yao, David H. Young
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Patent number: 8859558Abstract: This present disclosure is related to the field of pyrazine carboxamides and their derivatives and the use of these compounds as fungicides.Type: GrantFiled: May 31, 2011Date of Patent: October 14, 2014Assignee: Dow AgroSciences, LLC.Inventors: Kristy Bryan, George E. Davis, Paul R. Graupner, Beth Lorsbach, W. John Owen, Francis E. Tisdell
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Publication number: 20140296065Abstract: The present disclosure is related to the field agrochemicals including 5-fluorocytosine and its derivatives and their use as fungicides.Type: ApplicationFiled: June 17, 2014Publication date: October 2, 2014Inventors: Zoltan L. Benko, Kristy Bryan, George E. Davis, Jeffrey B. Epp, Beth Lorsbach, Kevin G. Meyer, W. John Owen, Michael T. Sullenberger, Jeffery D. Webster, David H. Young, Chenglin Yao
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Publication number: 20140275123Abstract: Various aspects disclosed herein relate to aryl substituted aminopyrimidines according to Formula 1: wherein, X1 is N or C—R3; X2 is N or C—R4 provided that X1 and X2 are not both N; R1-R7 are H, CN, CHO, —SCN, NO2, F, Cl, Br, I, substituted or unsubstituted C1-C4-alkyl, substituted or unsubstituted halo-C1-C4-alkyl, substituted or unsubstituted C1-C4-alkoxy, substituted or unsubstituted halo-C1-C4-alkoxy, substituted or unsubstituted C1-C4-thioalkyl, substituted or unsubstituted halo-C1-C4-thioalkyl, substituted or unsubstituted C3-C-7-cycloalkyl, substituted or unsubstituted C2-C4-alkenyl, C2-C4-alkynyl, substituted or unsubstituted C1-C4-acylalkyl, C1-C4-acyloxy, C1-C4 alkoxycarbonyl, C1-C4-alkoxy-amino, C1-C4-alkyl-S(O)?NH, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, wherein the substituents are one or more of the following F, Cl, Br, OH, CN, NO2, CHO, —SCN, S(O)n-C1-C4-alkyl (where n=0-2), C1-C4-alkyl, halo-C1-C4-alkyl, C1-C4-alkylamine, C1-C4-alkoxy, halo-C1-C4-alkoxType: ApplicationFiled: May 28, 2014Publication date: September 18, 2014Inventors: Francis Tisdell, JR., James M. Renga, David H. Young, George E. Davis, William C. Lo, Maurice C.H. Yap
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Patent number: 8759356Abstract: Various aspects disclosed herein relate to aryl substituted aminopyrimidines according to Formula 1: wherein, X1 is N or C—R3; X2 is N or C—R4 provided that X1 and X2 are not both N; R1-R7 are H, CN, CHO, —SCN, NO2, F, Cl, Br, I, substituted or unsubstituted C1-C4-alkyl, substituted or unsubstituted halo-C1-C4-alkyl, substituted or unsubstituted C1-C4-alkoxy, substituted or unsubstituted halo-C1-C4-alkoxy, substituted or unsubstituted C1-C4-thioalkyl, substituted or unsubstituted halo-C1-C4-thioalkyl, substituted or unsubstituted C3-C-7-cycloalkyl, substituted or unsubstituted C2-C4-alkenyl, C2-C4-alkynyl, substituted or unsubstituted C1-C4-acylalkyl, C1-C4-acyloxy, C1-C4 alkoxycarbonyl, C1-C4-alkoxy-amino, C1-C4-alkyl-S(O)?NH, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, wherein the substituents are one or more of the following F, Cl, Br, OH, CN, NO2, CHO, —SCN, S(O)n-C1-C4-alkyl (where n=0-2), C1-C4-alkyl, halo-C1-C4-alkyl, C1-C4-alkylamine, C1-C4-alkoxy, halo-C1-C4-alkoxType: GrantFiled: May 3, 2010Date of Patent: June 24, 2014Assignee: Dow AgroSciences, LLC.Inventors: Francis E. Tisdell, James M. Renga, William C. Lo, Maurice C. H. Yap, David H. Young, George E. Davis
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Publication number: 20120220457Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo [1,2- a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.Type: ApplicationFiled: November 5, 2010Publication date: August 30, 2012Applicants: Dow AgroSciences LLC, University of Notre Dame du LacInventors: Marvin J. Miller, Garrett C. Moraski, Lowell D. Markley, George E. Davis
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Publication number: 20110301178Abstract: This present disclosure is related to the field of pyrazine carboxamides and their derivatives and the use of these compounds as fungicides.Type: ApplicationFiled: May 31, 2011Publication date: December 8, 2011Applicant: DOW AGROSCIENCES LLCInventors: Kristy Bryan, George E. Davis, Paul R. Graupner, Beth Lorsbach, W. John Owen, Francis E. Tisdell
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Publication number: 20100298143Abstract: Various aspects disclosed herein relate to aryl substituted aminopyrimidines according to Formula 1: wherein, X1 is N or C—R3; X2 is N or C—R4 provided that X1 and X2 are not both N; R1-R7 are H, CN, CHO, —SCN, NO2, F, Cl, Br, I, substituted or unsubstituted C1-C4-alkyl, substituted or unsubstituted halo-C1-C4-alkyl, substituted or unsubstituted C1-C4-alkoxy, substituted or unsubstituted halo-C1-C4-alkoxy, substituted or unsubstituted C1-C4-thioalkyl, substituted or unsubstituted halo-C1-C4-thioalkyl, substituted or unsubstituted C3-C-7-cycloalkyl, substituted or unsubstituted C2-C4-alkenyl, C2-C4-alkynyl, substituted or unsubstituted C1-C4-acylalkyl, C1-C4-acyloxy, C1-C4 alkoxycarbonyl, C1-C4-alkoxy-amino, C1-C4-alkyl-S(O)?NH, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, wherein the substituents are one or more of the following F, Cl, Br, OH, CN, NO2, CHO, —SCN, S(O)n-C1-C4-alkyl (where n=0-2), C1-C4-alkyl, halo-C1-C4-alkyl, C1-C4-alkylamine, C1-C4-alkoxy, halo-C1-C4-alkoxType: ApplicationFiled: May 3, 2010Publication date: November 25, 2010Applicant: DOW AGROSCIENCES LLCInventors: Francis E. Tisdell, James M. Renga, William C. Lo, Maurice C. H. Yap, David H. Young, George E. Davis
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Publication number: 20100029482Abstract: The present disclosure is related to the field agrochemicals including 5-fluorocytosine and its derivatives and their use as fungicides.Type: ApplicationFiled: July 31, 2009Publication date: February 4, 2010Inventors: Zoltan L. Benko, Kristy Bryan, George E. Davis, Jeffrey B. Epp, Beth Lorsbach, Kevin G. Meyer, W. J. Owen, Michael T. Sullenberger, Jeffery D. Webster, David H. Young, Chenglin Yao
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Publication number: 20090203647Abstract: This present disclosure is related to the field of 5-fluoro pyrimidines and their derivatives and to the use of these compounds as fungicides.Type: ApplicationFiled: January 22, 2009Publication date: August 13, 2009Applicant: DOW AGROSCIENCES LLCInventors: Zoltan L. Benko, Timothy Boebel, Nneka T. Breaux, Kristy Bryan, George E. Davis, Jeffrey B. Epp, Beth Lorsbach, Timothy P. Martin, Kevin G. Meyer, Bassam S. Nader, W. J. Owen, Mark A. Pobanz, James M. Ruiz, Frisby D. Smith, Michael T. Sullenberger, Jeffery D. Webster, Chenglin Yao, David H. Young
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Publication number: 20020064831Abstract: Differential gene expression assays were used to identify a number of sequences in an in vitro model of human capillary tube formation. Nucleic acid sequences encoding the capillary morphogenesis gene CMG-1 and CMG-2 proteins are disclosed. The nucleic acids and proteins are useful in constructing vectors, recombinant cells, fusion proteins, and in methods for the isolation of matrix proteins.Type: ApplicationFiled: October 12, 2001Publication date: May 30, 2002Applicant: The Texas A&M University SystemInventors: George E. Davis, Scott E. Bell
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Patent number: 6333432Abstract: Fungicidal compositions and methods comprising acylated aminosalicylamides (AASA) described herein. Novel amines and 3-nitrosalicylamides, and their use as pesticides and in the preparation of the antifungal AASA compounds are also disclosed.Type: GrantFiled: May 1, 2000Date of Patent: December 25, 2001Inventors: Gina M. Fitzpatrick, Ann B. Orth, Maurice C. H. Yap, Richard B. Rogers, Todd L. Werk, George E. Davis
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Patent number: 5976848Abstract: Dihydroorotate dehydrogenase (DHOD) inhibititon assays are utilized in a method for identifying new fungicides; DHOD inhibitors are useful in fungicidal methods and compositions. Resistance genes that are mutants of the wild-type Aspergillus nidulans dihydroorotate dehydrogenase gene have been isolated and found to impart resistance to certain DHOD inhibitors. The resistance genes are useful as selectable markers in fungi. The wild-type gene is also provided.Type: GrantFiled: January 30, 1992Date of Patent: November 2, 1999Assignee: Dow AgroSciences LLCInventors: George E. Davis, Gary D. Gustafson, Matthew J. Henry, Amy J. Smith, Clive Waldron
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Patent number: 5884971Abstract: A releasably mounted back rest is provided including a cushion and a pair of vertical stanchions coupled at top ends thereof to the rear surface of the cushion extended downwardly a predetermined distance. Also included is a joint assembly comprising a pair of lower members hingably coupled to the stanchions. By this structure, the stanchions and lower members of the joint assembly are adapted to pivot between a first orientation wherein the same are linearly aligned and a second orientation wherein the same are situated perpendicular with respect to each other. Lastly, a clamp is situated at bottom ends of the lower members for releasably coupling with a seat.Type: GrantFiled: December 17, 1997Date of Patent: March 23, 1999Inventors: Shelvie J. Davis, George E. Davis