Abstract: A unique method is disclosed for identifying and replacing immunoglobulin surface amino acid residues which converts the antigenicity of a first mammalian species to that of a second mammalian species. The method will simultaneously change immunogenicity and strictly preserve ligind binding properties. The judicious replacement of exterior amino acid residues has no effect on the ligind binding properties but greatly alters immunogenicity.

Abstract: A unique method is disclosed for identifying and replacing immunoglobulin surface amino acid residues which converts the antigenicity of a first mammalian species to that of a second mammalian species. The method will simultaneously change immunogenicity and strictly preserve ligind binding properties. The judicious replacement of exterior amino acid residues has no effect on the ligind binding properties but greatly alters immunogenicity.

Abstract: A specific locus in the genome of a murine host cell is identified which causes high levels of recombinant gene expression following stable integration, via homologous recombination, of the recombinant gene into the specific chromosomal locus. The selection of a favorable genome locus for the insertion and expression of a recombinant gene is disclosed, as are DNA vectors and host cells.

Abstract: A specific locus in the genome of a murine host cell is identified which causes high levels of recombinant gene expression following stable integration, via homologous recombination, of the recombinant gene into the specific chromosomal locus. The selection of a favorable genome locus for the insertion and expression of a recombinant gene is disclosed, as are DNA vectors and host cells.

Abstract: A specific locus in the genome of a murine host cell is identified which causes high levels of recombinant gene expression following stable integration, via homologous recombination, of the recombinant gene into the specific chromosomal locus. The selection of a favorable genome locus for the insertion and expression of a recombinant gene is disclosed, as are DNA vectors and host cells.

Abstract: A specific locus in the genome of a murine host cell is identified which causes high levels of recombinant gene expression following stable integration, via homologous recombination, of the recombinant gene into the specific chromosomal locus. The selection of a favorable genome locus for the insertion and expression of a recombinant gene is disclosed, as are DNA vectors and host cells.

Abstract: A sander for smoothing curvilinear surfaces includes a horizontal support surface having top and bottom sides. The support surface has two sets of inner and outer arcuate slots thereon. The inner arcuate slots each have idler rollers thereabove secured to a pivoting, spring biased circular plate therebelow. A continuous sanding belt encompasses the idler rollers and a drive roller and is moved along a substantially triangular path with a motor means. A section of the path defines a sanding portion immediately adjacent to which is a flexible plate. An adjustment mechanism is provided to bend the plate to a desired configuration to form a curved sanding portion. The plate has an anchoring post on each side that is received within an outer arcuate slot and is secured to the circular plate therebelow. The plates, idler rollers and anchoring posts maintain tension on the belt regardless of the orientation of the sanding surface.

Abstract: A unique method is disclosed for identifying and replacing immunoglobulin surface amino acid residues which converts the antigenicity of a first mammalian species to that of a second mammalian species. The method will simultaneously change immunogenicity and strictly preserve ligind binding properties. The judicious replacement of exterior amino acid residues has no effect on the ligind binding properties but greatly alters immunogenicity.

Abstract: Vaccine formulations comprising recombinant early (E) and late (L) proteins of papillomavirus and oxidized mannan as well as methods of making and using the formulations are provided.

Abstract: Purified plasminogen activator proteins obtained or derived from the vampire bat Desmodus rotundus saliva and salivary glands, methods for purifying the proteins, DNA sequences encoding these proteins, means for producing them using recombinant DNA technology, pharmaceutical compositions comprising these proteins and methods of treatment utilizing these proteins are provided.

Abstract: The present invention is a series of synthetic virus-like particles useful in the characterization of human papillomavirus infection and assays employing the synthetic virus-like particles.

Abstract: The present invention is a series of synthetic virus-like particles useful in the characterization of human papillomavirus infection and assays employing the synthetic virus-like particles. The synthetic virus-like particles are generated from constructs designated as HPV6:4; HPV6:5; HPV6:2; HPV6:4.DELTA.132; and HPV6:4,S131G.

Abstract: A door hinge assembly pivotably mounts a vehicle door member to a body structure member. The assembly includes a first hinge strap mounted to one of the members and having a vertical opening. A second hinge strap is mounted to the other member and has a spherical concave surface. A hinge pin is interposed between the hinge straps. The hinge pin has a portion received by the vertical opening of the first hinge strap. The hinge pin has a spherical convex surface for engaging the concave surface of the second hinge strap allowing variance in relative orientation of the hinge pin to the second hinge strap. The hinge pin is rotatably retained to one of the hinge straps allowing pivotable movement between the members. A removable retention bolt is carried between the hinge pin and the other hinge strap for retaining the hinge pin to the other hinge strap. The retention bolt allows removable retention of the door member to the body structure member.

Abstract: A protein having a molecular weight of about 6,000 daltons which is biologically active in the inhibition of Factor Xa during the blood coagulation cascade, a method for producing the protein, methods for inhibiting blood coagulation using the protein, and suitable pharmaceutical compositions.