Patents by Inventor George E. Pierce
George E. Pierce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11504418Abstract: Disclosed herein is an endotoxin-free asparaginase enzyme. Also disclosed are methods of using the disclosed enzyme to treat subjects with a disease treatable by depletion of asparagine. For example, the disclosed endotoxin-free asparaginase enzyme is useful in the treatment or the manufacture of a medicament for use in the treatment of acute lymphoblastic leukemia (ALL) in both adults and children, as well as other conditions where asparagine depletion is expected to have a useful effect.Type: GrantFiled: November 2, 2017Date of Patent: November 22, 2022Assignee: CROWPIERCE TECHNOLOGIES, LLCInventors: George E. Pierce, Sidney A. Crow
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Publication number: 20200010503Abstract: Provided herein are methods of producing a heterologous polypeptide and compositions comprising same.Type: ApplicationFiled: September 5, 2018Publication date: January 9, 2020Inventors: George E. Pierce, Susan A. Burran, Trudy Ann Tucker, Shelby Jones-Dozier, Jennifer Hooker, Sidney A. Crow
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Publication number: 20190275121Abstract: Disclosed herein is an endotoxin-free asparaginase enzyme. Also disclosed are methods of using the disclosed enzyme to treat subjects with a disease treatable by depletion of asparagine. For example, the disclosed endotoxin-free asparaginase enzyme is useful in the treatment or the manufacture of a medicament for use in the treatment of acute lymphoblastic leukemia (ALL) in both adults and children, as well as other conditions where asparagine depletion is expected to have a useful effect.Type: ApplicationFiled: November 2, 2017Publication date: September 12, 2019Inventors: George E. Pierce, Sidney A. Crow
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Patent number: 10300093Abstract: Provided are methods and compositions for inhibiting or reducing fungal growth in or on a subject. The methods comprise exposing the subject to a composition comprising one or more enzymes, one or more bacteria, and/or an enzymatic extract, wherein the one or more enzymes, one or more bacteria, and/or the enzymatic extract isolated from one or more bacteria are exposed to the subject in a quantity sufficient to inhibit or reduce fungal growth.Type: GrantFiled: June 10, 2015Date of Patent: May 28, 2019Assignee: Georgia State University Research Foundation, Inc.Inventors: George E. Pierce, Sidney A. Crow, Jr., Trudy Ann Tucker, Christopher T. Cornelison
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Publication number: 20190133137Abstract: Provided are methods and compositions for inhibiting seed germination. The methods comprise exposing a seed to a composition comprising one or more enzymes, one or more bacteria, and/or an enzymatic extract, wherein the one or more enzymes, one or more bacteria, and/or the enzymatic extract isolated from one or more bacteria are exposed to seed in a quantity sufficient to inhibit seed germination.Type: ApplicationFiled: June 6, 2017Publication date: May 9, 2019Inventors: George E. Pierce, Sidney A. Crow
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Patent number: 10244765Abstract: Provided are methods and compositions for inhibiting or reducing fungal growth. The methods comprise exposing a location to a composition comprising one or more enzymes, one or more bacteria, and/or an enzymatic extract, wherein the one or more enzymes, one or more bacteria, and/or the enzymatic extract isolated from one or more bacteria are exposed to location in a quantity sufficient to inhibit or reduce fungal growth.Type: GrantFiled: May 21, 2018Date of Patent: April 2, 2019Assignee: Georgia State University Research Foundation, Inc.Inventors: George E. Pierce, Sidney Crow
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Publication number: 20180332859Abstract: Provided are methods and compositions for inhibiting or reducing fungal growth. The methods comprise exposing a location to a composition comprising one or more enzymes, one or more bacteria, and/or an enzymatic extract, wherein the one or more enzymes, one or more bacteria, and/or the enzymatic extract isolated from one or more bacteria are exposed to location in a quantity sufficient to inhibit or reduce fungal growth.Type: ApplicationFiled: May 21, 2018Publication date: November 22, 2018Inventors: George E. Pierce, Sidney Crow
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Patent number: 10004237Abstract: Provided are methods and compositions for inhibiting or reducing fungal growth. The methods comprise exposing a location to a composition comprising one or more enzymes, one or more bacteria, and/or an enzymatic extract, wherein the one or more enzymes, one or more bacteria, and/or the enzymatic extract isolated from one or more bacteria are exposed to location in a quantity sufficient to inhibit or reduce fungal growth.Type: GrantFiled: March 13, 2014Date of Patent: June 26, 2018Assignee: Georgia State University Research Foundation, Inc.Inventors: George E. Pierce, Sidney Crow
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Patent number: 9993005Abstract: Provided are methods and compositions for preventing or delaying a chill injury response of a plant or plant part that exhibits a chill injury response. The methods comprise exposing the plant or plant part to one or more bacteria, one or more enzymes, and/or an enzymatic extract isolated from one or more bacteria. The one or more bacteria, one or more enzymes, and/or the enzymatic extract isolated from one or more bacteria are exposed to the plant or plant part in a quantity sufficient to prevent or delay the chill injury response of the plant or plant part.Type: GrantFiled: March 12, 2014Date of Patent: June 12, 2018Assignee: Georgia State University Research Foundation, Inc.Inventor: George E. Pierce
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Publication number: 20170112882Abstract: Provided are methods and compositions for inhibiting or reducing fungal growth in or on a subject. The methods comprise exposing the subject to a composition comprising one or more enzymes, one or more bacteria, and/or an enzymatic extract, wherein the one or more enzymes, one or more bacteria, and/or the enzymatic extract isolated from one or more bacteria are exposed to the subject in a quantity sufficient to inhibit or reduce fungal growth.Type: ApplicationFiled: June 10, 2015Publication date: April 27, 2017Applicant: GEORGIA STATE UNIVERSITY AND RESEARCH FOUNDATION INC.Inventors: George E. Pierce, Sidney A. Crow, Jr., Trudy Ann Tucker, Christopher T. Cornelison
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Publication number: 20170114383Abstract: Provided herein are methods of producing a heterologous polypeptide and compositions comprising same.Type: ApplicationFiled: January 6, 2017Publication date: April 27, 2017Inventors: George E. Pierce, Susan A. Burran, Trudy Ann Tucker, Shelby Jones-Dozier, Jennifer Hooker, Sidney A. Crow, JR.
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Patent number: 9605241Abstract: The present invention is directed to methods for inducing desired activity in enzymes or microorganisms capable of producing the enzymes. The invention is further directed to methods of stabilizing activity in microorganisms. In specific embodiments, the invention provides methods for inducing and stabilizing nitrile hydratase activity, amidase activity, and asparaginase I activity. The invention further provides compositions comprising enzymes or microorganisms having induced and/or stabilized activity.Type: GrantFiled: November 2, 2012Date of Patent: March 28, 2017Assignee: Georgia State University Research Foundation, Inc.Inventors: George E. Pierce, Gene K. Drago, Sangeeta Ganguly
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Patent number: 9462813Abstract: The present invention is directed to methods for delaying a plant development process comprising exposing a plant or plant part to one or more bacteria or enzymes. In specific embodiments, the one or more bacteria are selected from the group consisting of Rhodococcus spp., Pseudomonas chloroaphis, Brevibacterium ketoglutamicum, and a mixture comprising any combination of these bacteria. Apparatuses for delaying a plant development process comprising a catalyst that comprises one or more of the above bacteria.Type: GrantFiled: March 4, 2013Date of Patent: October 11, 2016Assignee: Georgia State University Research Foundation, Inc.Inventors: George E. Pierce, Sangeeta Ganguly-Mink, Gene K. Drago
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Publication number: 20160021890Abstract: Provided are methods and compositions for inhibiting or reducing fungal growth. The methods comprise exposing a location to a composition comprising one or more enzymes, one or more bacteria, and/or an enzymatic extract, wherein the one or more enzymes, one or more bacteria, and/or the enzymatic extract isolated from one or more bacteria are exposed to location in a quantity sufficient to inhibit or reduce fungal growth.Type: ApplicationFiled: March 13, 2014Publication date: January 28, 2016Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: George E. Pierce, Sidney Crow
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Publication number: 20160015039Abstract: Provided are methods and compositions for preventing or delaying a chill injury response of a plant or plant part that exhibits a chill injury response. The methods comprise exposing the plant or plant part to one or more bacteria, one or more enzymes, and/or an enzymatic extract isolated from one or more bacteria. The one or more bacteria, one or more enzymes, and/or the enzymatic extract isolated from one or more bacteria are exposed to the plant or plant part in a quantity sufficient to prevent or delay the chill injury response of the plant or plant part.Type: ApplicationFiled: March 12, 2014Publication date: January 21, 2016Inventor: George E. Pierce
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Publication number: 20150056653Abstract: Provided herein are methods of producing a heterologous polypeptide and compositions comprising same.Type: ApplicationFiled: July 27, 2012Publication date: February 26, 2015Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: George E. Pierce, Susan A. Burran, Trudy Ann Tucker, Shelby Jones-Dozier, Jennifer Hooker, Sidney A. Crow, JR.
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Patent number: 8389441Abstract: The present invention is directed to methods for delaying a plant development process comprising exposing a plant or plant part to one or more bacteria or enzymes. In specific embodiments, the one or more bacteria are selected from the group consisting of Rhodococcus spp., Pseudomonas chloroaphis, Brevibacterium ketoglutamicum, and a mixture comprising any combination of these bacteria. Apparatuses for delaying a plant development process comprising a catalyst that comprises one or more of the above bacteria.Type: GrantFiled: April 11, 2011Date of Patent: March 5, 2013Assignee: Georgia State University Research Foundation, Inc.Inventors: George E. Pierce, Sangeeta Ganguly, Gene K. Drago
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Publication number: 20130035232Abstract: Provided herein are methods for inducing and stabilizing an enzyme activity. Optionally, the enzyme is in a microorganism capable of producing the enzyme. In some embodiments, the enzyme can be nitrile hydratase, amidase, or asparaginase I. Provided are compositions comprising enzymes or microorganisms having induced and/or stabilized activity. Also provided are methods of delaying a plant development process by exposing a plant or plant part to the enzymes or microorganisms having induced and/or stabilized activity.Type: ApplicationFiled: January 24, 2011Publication date: February 7, 2013Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: George E. Pierce, Trudy Ann Tucker
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Patent number: 8323942Abstract: The present invention is directed to methods for inducing desired activity in enzymes or microorganisms capable of producing the enzymes. The invention is further directed to methods of stabilizing activity in microorganisms. In specific embodiments, the invention provides methods for inducing and stabilizing nitrile hydratase activity, amidase activity, and asparaginase I activity. The invention further provides compositions comprising enzymes or microorganisms having induced and/or stabilized activity.Type: GrantFiled: April 3, 2009Date of Patent: December 4, 2012Assignee: Georgia State University Research FoundationInventors: George E. Pierce, Gene K. Drago, Sangeeta Ganguly
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Publication number: 20110183847Abstract: The present invention is directed to methods for delaying a plant development process comprising exposing a plant or plant part to one or more bacteria or enzymes. In specific embodiments, the one or more bacteria are selected from the group consisting of Rhodococcus spp., Pseudomonas chloroaphis, Brevibacterium ketoglutamicum, and a mixture comprising any combination of these bacteria. Apparatuses for delaying a plant development process comprising a catalyst that comprises one or more of the above bacteria.Type: ApplicationFiled: April 11, 2011Publication date: July 28, 2011Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: George E. Pierce, Sangeeta Ganguly, Gene K. Drago