Patents by Inventor George E. Pierce

George E. Pierce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11504418
    Abstract: Disclosed herein is an endotoxin-free asparaginase enzyme. Also disclosed are methods of using the disclosed enzyme to treat subjects with a disease treatable by depletion of asparagine. For example, the disclosed endotoxin-free asparaginase enzyme is useful in the treatment or the manufacture of a medicament for use in the treatment of acute lymphoblastic leukemia (ALL) in both adults and children, as well as other conditions where asparagine depletion is expected to have a useful effect.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: November 22, 2022
    Assignee: CROWPIERCE TECHNOLOGIES, LLC
    Inventors: George E. Pierce, Sidney A. Crow
  • Publication number: 20200010503
    Abstract: Provided herein are methods of producing a heterologous polypeptide and compositions comprising same.
    Type: Application
    Filed: September 5, 2018
    Publication date: January 9, 2020
    Inventors: George E. Pierce, Susan A. Burran, Trudy Ann Tucker, Shelby Jones-Dozier, Jennifer Hooker, Sidney A. Crow
  • Publication number: 20190275121
    Abstract: Disclosed herein is an endotoxin-free asparaginase enzyme. Also disclosed are methods of using the disclosed enzyme to treat subjects with a disease treatable by depletion of asparagine. For example, the disclosed endotoxin-free asparaginase enzyme is useful in the treatment or the manufacture of a medicament for use in the treatment of acute lymphoblastic leukemia (ALL) in both adults and children, as well as other conditions where asparagine depletion is expected to have a useful effect.
    Type: Application
    Filed: November 2, 2017
    Publication date: September 12, 2019
    Inventors: George E. Pierce, Sidney A. Crow
  • Patent number: 10300093
    Abstract: Provided are methods and compositions for inhibiting or reducing fungal growth in or on a subject. The methods comprise exposing the subject to a composition comprising one or more enzymes, one or more bacteria, and/or an enzymatic extract, wherein the one or more enzymes, one or more bacteria, and/or the enzymatic extract isolated from one or more bacteria are exposed to the subject in a quantity sufficient to inhibit or reduce fungal growth.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: May 28, 2019
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: George E. Pierce, Sidney A. Crow, Jr., Trudy Ann Tucker, Christopher T. Cornelison
  • Publication number: 20190133137
    Abstract: Provided are methods and compositions for inhibiting seed germination. The methods comprise exposing a seed to a composition comprising one or more enzymes, one or more bacteria, and/or an enzymatic extract, wherein the one or more enzymes, one or more bacteria, and/or the enzymatic extract isolated from one or more bacteria are exposed to seed in a quantity sufficient to inhibit seed germination.
    Type: Application
    Filed: June 6, 2017
    Publication date: May 9, 2019
    Inventors: George E. Pierce, Sidney A. Crow
  • Patent number: 10244765
    Abstract: Provided are methods and compositions for inhibiting or reducing fungal growth. The methods comprise exposing a location to a composition comprising one or more enzymes, one or more bacteria, and/or an enzymatic extract, wherein the one or more enzymes, one or more bacteria, and/or the enzymatic extract isolated from one or more bacteria are exposed to location in a quantity sufficient to inhibit or reduce fungal growth.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: April 2, 2019
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: George E. Pierce, Sidney Crow
  • Publication number: 20180332859
    Abstract: Provided are methods and compositions for inhibiting or reducing fungal growth. The methods comprise exposing a location to a composition comprising one or more enzymes, one or more bacteria, and/or an enzymatic extract, wherein the one or more enzymes, one or more bacteria, and/or the enzymatic extract isolated from one or more bacteria are exposed to location in a quantity sufficient to inhibit or reduce fungal growth.
    Type: Application
    Filed: May 21, 2018
    Publication date: November 22, 2018
    Inventors: George E. Pierce, Sidney Crow
  • Patent number: 10004237
    Abstract: Provided are methods and compositions for inhibiting or reducing fungal growth. The methods comprise exposing a location to a composition comprising one or more enzymes, one or more bacteria, and/or an enzymatic extract, wherein the one or more enzymes, one or more bacteria, and/or the enzymatic extract isolated from one or more bacteria are exposed to location in a quantity sufficient to inhibit or reduce fungal growth.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: June 26, 2018
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: George E. Pierce, Sidney Crow
  • Patent number: 9993005
    Abstract: Provided are methods and compositions for preventing or delaying a chill injury response of a plant or plant part that exhibits a chill injury response. The methods comprise exposing the plant or plant part to one or more bacteria, one or more enzymes, and/or an enzymatic extract isolated from one or more bacteria. The one or more bacteria, one or more enzymes, and/or the enzymatic extract isolated from one or more bacteria are exposed to the plant or plant part in a quantity sufficient to prevent or delay the chill injury response of the plant or plant part.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: June 12, 2018
    Assignee: Georgia State University Research Foundation, Inc.
    Inventor: George E. Pierce
  • Publication number: 20170112882
    Abstract: Provided are methods and compositions for inhibiting or reducing fungal growth in or on a subject. The methods comprise exposing the subject to a composition comprising one or more enzymes, one or more bacteria, and/or an enzymatic extract, wherein the one or more enzymes, one or more bacteria, and/or the enzymatic extract isolated from one or more bacteria are exposed to the subject in a quantity sufficient to inhibit or reduce fungal growth.
    Type: Application
    Filed: June 10, 2015
    Publication date: April 27, 2017
    Applicant: GEORGIA STATE UNIVERSITY AND RESEARCH FOUNDATION INC.
    Inventors: George E. Pierce, Sidney A. Crow, Jr., Trudy Ann Tucker, Christopher T. Cornelison
  • Publication number: 20170114383
    Abstract: Provided herein are methods of producing a heterologous polypeptide and compositions comprising same.
    Type: Application
    Filed: January 6, 2017
    Publication date: April 27, 2017
    Inventors: George E. Pierce, Susan A. Burran, Trudy Ann Tucker, Shelby Jones-Dozier, Jennifer Hooker, Sidney A. Crow, JR.
  • Patent number: 9605241
    Abstract: The present invention is directed to methods for inducing desired activity in enzymes or microorganisms capable of producing the enzymes. The invention is further directed to methods of stabilizing activity in microorganisms. In specific embodiments, the invention provides methods for inducing and stabilizing nitrile hydratase activity, amidase activity, and asparaginase I activity. The invention further provides compositions comprising enzymes or microorganisms having induced and/or stabilized activity.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: March 28, 2017
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: George E. Pierce, Gene K. Drago, Sangeeta Ganguly
  • Patent number: 9462813
    Abstract: The present invention is directed to methods for delaying a plant development process comprising exposing a plant or plant part to one or more bacteria or enzymes. In specific embodiments, the one or more bacteria are selected from the group consisting of Rhodococcus spp., Pseudomonas chloroaphis, Brevibacterium ketoglutamicum, and a mixture comprising any combination of these bacteria. Apparatuses for delaying a plant development process comprising a catalyst that comprises one or more of the above bacteria.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: October 11, 2016
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: George E. Pierce, Sangeeta Ganguly-Mink, Gene K. Drago
  • Publication number: 20160021890
    Abstract: Provided are methods and compositions for inhibiting or reducing fungal growth. The methods comprise exposing a location to a composition comprising one or more enzymes, one or more bacteria, and/or an enzymatic extract, wherein the one or more enzymes, one or more bacteria, and/or the enzymatic extract isolated from one or more bacteria are exposed to location in a quantity sufficient to inhibit or reduce fungal growth.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 28, 2016
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: George E. Pierce, Sidney Crow
  • Publication number: 20160015039
    Abstract: Provided are methods and compositions for preventing or delaying a chill injury response of a plant or plant part that exhibits a chill injury response. The methods comprise exposing the plant or plant part to one or more bacteria, one or more enzymes, and/or an enzymatic extract isolated from one or more bacteria. The one or more bacteria, one or more enzymes, and/or the enzymatic extract isolated from one or more bacteria are exposed to the plant or plant part in a quantity sufficient to prevent or delay the chill injury response of the plant or plant part.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 21, 2016
    Inventor: George E. Pierce
  • Publication number: 20150056653
    Abstract: Provided herein are methods of producing a heterologous polypeptide and compositions comprising same.
    Type: Application
    Filed: July 27, 2012
    Publication date: February 26, 2015
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: George E. Pierce, Susan A. Burran, Trudy Ann Tucker, Shelby Jones-Dozier, Jennifer Hooker, Sidney A. Crow, JR.
  • Patent number: 8389441
    Abstract: The present invention is directed to methods for delaying a plant development process comprising exposing a plant or plant part to one or more bacteria or enzymes. In specific embodiments, the one or more bacteria are selected from the group consisting of Rhodococcus spp., Pseudomonas chloroaphis, Brevibacterium ketoglutamicum, and a mixture comprising any combination of these bacteria. Apparatuses for delaying a plant development process comprising a catalyst that comprises one or more of the above bacteria.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: March 5, 2013
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: George E. Pierce, Sangeeta Ganguly, Gene K. Drago
  • Publication number: 20130035232
    Abstract: Provided herein are methods for inducing and stabilizing an enzyme activity. Optionally, the enzyme is in a microorganism capable of producing the enzyme. In some embodiments, the enzyme can be nitrile hydratase, amidase, or asparaginase I. Provided are compositions comprising enzymes or microorganisms having induced and/or stabilized activity. Also provided are methods of delaying a plant development process by exposing a plant or plant part to the enzymes or microorganisms having induced and/or stabilized activity.
    Type: Application
    Filed: January 24, 2011
    Publication date: February 7, 2013
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: George E. Pierce, Trudy Ann Tucker
  • Patent number: 8323942
    Abstract: The present invention is directed to methods for inducing desired activity in enzymes or microorganisms capable of producing the enzymes. The invention is further directed to methods of stabilizing activity in microorganisms. In specific embodiments, the invention provides methods for inducing and stabilizing nitrile hydratase activity, amidase activity, and asparaginase I activity. The invention further provides compositions comprising enzymes or microorganisms having induced and/or stabilized activity.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: December 4, 2012
    Assignee: Georgia State University Research Foundation
    Inventors: George E. Pierce, Gene K. Drago, Sangeeta Ganguly
  • Publication number: 20110183847
    Abstract: The present invention is directed to methods for delaying a plant development process comprising exposing a plant or plant part to one or more bacteria or enzymes. In specific embodiments, the one or more bacteria are selected from the group consisting of Rhodococcus spp., Pseudomonas chloroaphis, Brevibacterium ketoglutamicum, and a mixture comprising any combination of these bacteria. Apparatuses for delaying a plant development process comprising a catalyst that comprises one or more of the above bacteria.
    Type: Application
    Filed: April 11, 2011
    Publication date: July 28, 2011
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: George E. Pierce, Sangeeta Ganguly, Gene K. Drago