Patents by Inventor George F. Field
George F. Field has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5792389Abstract: Novel water soluble dyes of the formula I are provided ##STR1## wherein R.sup.1 and R.sup.4 are alkyl of 1 to 4 carbon atoms or hydrogen; or R.sup.1 -R.sup.2 or R.sup.2 -R.sup.4 form part of aliphatic heterocyclic rings; R.sup.2 is hydrogen or joined with R.sup.1 or R.sup.4 as described above; R.sup.3 is --(CH.sub.2).sub.m --SO.sub.3.sup.-, where m is 1 to 6;X is N, CH or ##STR2## where Y is 2 --SO.sub.3.sup.- ; Z is 3, 4, 5 or 6 --SO.sub.3.sup.-. The novel dyes are particularly useful as the active media in water solution dye lasers.Type: GrantFiled: October 27, 1993Date of Patent: August 11, 1998Assignee: United States of AmericaInventors: Peter R. Hammond, James F. Feeman, George F. Field
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Patent number: 5256799Abstract: A novel method for the synthesis of 6-hydroxyindolines and new fluorescent dyes produced therefrom, which dyes are ring-constrained indoline-based rhodamine class dyes. These dyes have absorption and emission spectra which make them particularly useful in certain dye laser applications.Type: GrantFiled: July 14, 1992Date of Patent: October 26, 1993Assignee: The United States of Americas as represented by the United States Department of EnergyInventors: George F. Field, Peter R. Hammond
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Patent number: 5149807Abstract: New oxazine compounds useful as dye laser media in solution, are superiior to prior art materials. The oxazine dyes useful when pumped by the 578.Type: GrantFiled: September 18, 1991Date of Patent: September 22, 1992Assignee: The United States of America, as represented by the United States Department of EnergyInventors: Peter R. Hammond, George F. Field
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Patent number: 5001140Abstract: The invention relates to compounds of the formula: ##STR1## wherein R is hydrogen or lower alkyl, R.sub.1, R.sub.2, R.sub.3 and R.sub.4, independently, are hydrogen, lower alkyl, lower alkenyl, cycloalkyl or phenyl unsubstituted or substituted by up to 3 substituents independently selected from lower alkyl, lower alkoxy or halogen, or R.sub.1 and R.sub.2 taken together with the carbon atom are alkylene of 2 to 5 carbon atoms unsubstituted or substituted by lower alkyl, and n is an integer of from 0 to 3,and, when R.sub.1 is different from R.sub.2 and/or when R.sub.3 is different from R.sub.4, enantiomers, diastereomers and racemates thereof and, when R is hydrogen, salts thereof with pharmaceutically acceptable bases.The compounds of formula I and, when R is hydrogen, pharmaceutically exceptable salts thereof are useful as bronchopulmonary agents, for example, in the relief of asthma and allergic reactions.Type: GrantFiled: June 13, 1989Date of Patent: March 19, 1991Assignee: Hoffmann-La Roche Inc.Inventors: George F. Field, John R. Vermeulen, William J. Zally
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Patent number: 4560692Abstract: Disclosed are compounds of the formula ##STR1## wherein: R.sup.1 and R.sub.2 may be either the same or different and each is hydrogen or lower alkyl;and wherein R.sup.3 and R.sup.4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R.sup.3 and R.sup.4 cannot both be hydrogen.These compounds are useful as anticonvulsant or anxiolytic agents.Type: GrantFiled: July 18, 1984Date of Patent: December 24, 1985Assignee: Hoffmann-La Roche Inc.Inventors: George F. Field, William J. Zally
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Patent number: 4460781Abstract: There are presented compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.6 is halo and R.sub.5 is hydrogen or halo; and compounds of the formulas ##STR2## wherein R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen, lower alkyl, C.sub.2 to C.sub.7 carboxylic acids, hydroxy C.sub.2 to C.sub.7 alkyl, C.sub.2 to C.sub.7 carboxylic acid esters and amides and the group COR.sub.11 wherein R.sub.11 and is selected from the group consisting of alkoxy, amino or mono-lower alkyl amino; R.sub.35 is hydrogen or lower alkyl; R.sub.5 is hydrogen or halo; and R.sub.7 is methyl or chloromethyl, all of which are useful in the preparation of pyrazolobenzazepines.Type: GrantFiled: January 5, 1983Date of Patent: July 17, 1984Assignee: Hoffmann-La Roche Inc.Inventors: George F. Field, Rodney I. Fryer, Eugene J. Trybulski, Armin Walser
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Patent number: 4379765Abstract: There are presented compounds of the formulas ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen, lower alkyl, C.sub.2 to C.sub.7 carboxylic acids, hydroxy C.sub.2 to C.sub.7 alkyl, C.sub.2 to C.sub.7 carboxylic acid esters and amides and the group COR.sub.11 wherein R.sub.11 is alkoxy, amino or mono- lower alkyl amino; R.sub.6 is nitro or halo and R.sub.5 is hydrogen or halo,and the pharmaceutically acceptable salts thereof.The pyrazolobenzazepines are useful as anxiolytic and sedative agents.Also provided are processes and intermediates in the production of the above pyrazolobenzazepines.Type: GrantFiled: July 23, 1981Date of Patent: April 12, 1983Assignee: Hoffmann-La Roche Inc.Inventors: George F. Field, Rodney I. Fryer, Eugene J. Trybulski, Armin Walser
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Patent number: 4281142Abstract: A multistep process is presented for the preparation of imidazobenzodiazepines of the formula ##STR1## wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl.Also presented are novel intermediates utilized in the process.The end products are useful as sedatives, anxiolytics, muscle relaxants and anticonvulsants.The end products are especially useful in intravenous compositions for use in preoperative anesthesia.Type: GrantFiled: September 27, 1979Date of Patent: July 28, 1981Assignee: Hoffmann-La Roche Inc.Inventors: George F. Field, William J. Zally
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Patent number: 4256637Abstract: Novel intermediates of the formula ##STR1## wherein X and Y are hydrogen, halogen or trifluoromethyl and R.sub.1 is hydrogen or lower alkyl are presented.Also disclosed is a process leading to the intermediates and their conversion to imidazobenzodiazepines, compounds of pharmacological activity.Type: GrantFiled: July 7, 1980Date of Patent: March 17, 1981Assignee: Hoffmann-La Roche Inc.Inventors: George F. Field, William J. Zally
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Patent number: 4238610Abstract: Novel intermediates of the formula ##STR1## wherein X and Y are hydrogen, halogen or trifluoromethyl and R.sub.1 is hydrogen or lower alkyl are presented.Also disclosed is a process leading to the intermediates and their conversion to imidazobenzodiazepines, compounds of pharmacological activity.Type: GrantFiled: December 20, 1979Date of Patent: December 9, 1980Assignee: Hoffmann-La Roche Inc.Inventors: George F. Field, William J. Zally
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Patent number: 4194049Abstract: A multistep process is presented for the preparation of imidazobenzodiazepines of the formula ##STR1## wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl.Also presented are novel intermediates utilized in the process.The end products are useful as sedatives, anxiolytics, muscle relaxants and anticonvulsants.The end products are especially useful in intravenous compositions for use in preoperative anesthesia.Type: GrantFiled: March 29, 1979Date of Patent: March 18, 1980Assignee: Hoffmann-La Roche Inc.Inventors: George F. Field, William J. Zally