Patents by Inventor George F. Glass

George F. Glass has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Serial multiple antigen colocalization in paraffin-embedded tissue
    Patent number: 8753824
    Abstract: The present invention provides a novel method called Sequential IMmunoPeroxidase Labeling and Erasing (SIMPLE) that enables the simultaneous visualization of at least five markers within a single tissue section. Utilizing the alcohol-soluble peroxidase substrate 3-amino-9-ethylcarbazole (AEC), combined with a rapid non-destructive method for antibody-antigen dissociation, the present application discloses the ability to erase the results of a single immunohistochemical stain while preserving tissue antigenicity for repeated rounds of labeling. The present invention also provides methods for visualizing multiple antigens simultaneously.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: June 17, 2014
    Assignee: University of Virginia Patent Foundation
    Inventors: Jason A. Papin, James W. Mandell, George F. Glass
  • SERIAL MULTIPLE ANTIGEN COLOCALIZATION IN PARAFFIN-EMBEDDED TISSUE
    Publication number: 20120021439
    Abstract: The present invention provides a novel method called Sequential IMmunoPeroxidase Labeling and Erasing (SIMPLE) that enables the simultaneous visualization of at least five markers within a single tissue section. Utilizing the alcohol-soluble peroxidase substrate 3-amino-9-ethylcarbazole (AEC), combined with a rapid non-destructive method for antibody-antigen dissociation, the present application discloses the ability to erase the results of a single immunohistochemical stain while preserving tissue antigenicity for repeated rounds of labeling. The present invention also provides methods for visualizing multiple antigens simultaneously.
    Type: Application
    Filed: April 2, 2010
    Publication date: January 26, 2012
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Jason A. Papin, James W. Mandell, George F. Glass