Patents by Inventor George F. Huhn

George F. Huhn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline 10,10-Bis((2-fluoro-4-pyridinyl)methyl)-9(10H)-Anthracenone and an improved process for preparing the same
    Patent number: 6214847
    Abstract: The present invention relates to processes for the synthesis of a crystalline polymorph of 10,10-Bis((2-fluoro-4-pyridinyl)methyl)-9(10H)-Anthracenone in high purity. The product is useful in the synthesis of pharmaceutical compounds for the reduction of cholinergic system dysfunction.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: April 10, 2001
    Assignee: Dupont Pharmaceuticals Company
    Inventors: Jaan A. Pesti, Joseph M. Fortunak, George F. Huhn, Michael Maurin, Jianguo Yin
  • Process for purifying nucleoside-5'-diphosphates
    Patent number: 5109125
    Abstract: This invention is a process for purifying nucleoside-5'-diphosphates containing substituents other than primary amines (hereinafter designated as NDPs) from complex mixtures by contacting the aqueous solution mixture with a strongly basic ion exchange resin in the chloride form, eluting certain absorbed impurities with an alkali metal salt solution, converting the column to the hydroxide form by contacting the resin with an alkali metal hydroxide solution such that the effluent becomes basic, and eluting absorbed NDP with a weakly acidic alkali metal salt solution such that solutions of highly pure NDP are obtained in basic effluent fractions. The new process is particularly valuable for purification of NDPs directly from chemical synthesis reaction media.
    Type: Grant
    Filed: April 7, 1989
    Date of Patent: April 28, 1992
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: George F. Huhn, James H. Jensen
  • Process for preparing 3,3-disubstituted indolines
    Patent number: 4806651
    Abstract: Processes for preparing 3,3-disubstituted indolines, particularly 3,3-dipyridine substituted indolines useful to treat cognitive or neurological dysfunction in a mammal, are provided.
    Type: Grant
    Filed: October 7, 1987
    Date of Patent: February 21, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Walter M. Bryant, III, George F. Huhn