Patent number: 6184226
Abstract: The invention describes compounds of the formula
and the pharmaceutically acceptable salts thereof
and the pharmaceutically acceptable salts thereof
wherein each R2 is independently a noninterfering substituent;
m is an integer of 0-4;
Z is CH or N;
R1 is H, alkyl (1-6C) or arylalkyl optionally substituted on the aryl group with 1-3 substituents independently selected from alkyl (1-6C), halo, OR, NR2, SR, —OOCR, —NROCR, RCO, —COOR, —CONR2, —SO2NR2, CN, CF3, and NO2, wherein each R is independently H or lower alkyl (1-4C);
n is 0, 1 or 2;
Ar is phenyl, pyridyl, indolyl, or pyrimidyl, each optionally substituted with a group selected from the group consisting of optionally substituted alkyl (1-6C), halo, OR, NR2, SR, —OOCR, —NROCR, RCO, —COOR, —CONR2, SO2NR2, CN, CF3, and NO2, wherein each R is independently H or lower alkyl (1-4C); and
R3 is a branched or cyclic alkyl group (5-7C) or is phenyl optionally substituted with 1-2 substi
Type:
Grant
Filed:
August 28, 1998
Date of Patent:
February 6, 2001
Assignee:
Scios Inc.
Inventors:
Sarvajit Chakravarty, John J. Perumattam, George F. Schreiner, David Y. Liu, John A. Lewicki