Patents by Inventor George F. Widhopf, II

George F. Widhopf, II has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MONOCLONAL ANTIBODIES SPECIFIC FOR HUMAN ROR1
    Publication number: 20240117047
    Abstract: Provided herein are, inter alia, antibodies (e.g. humanized antibodies, monoclonal antibodies, antibody fragments (e.g., scFvs) and antibody compositions (e.g., chimeric antigen receptors, bispecific antibodies), which bind human tyrosine kinase-like orphan receptor 1 (ROR1) with high efficiency and specificity. The antibodies and antibody compositions provided herein include novel light and heavy chain domain CDRs and framework regions and are, inter alia, useful for diagnosing and treating cancer and other ROR1-related diseases.
    Type: Application
    Filed: February 11, 2022
    Publication date: April 11, 2024
    Inventors: Thomas J. KIPPS, Charles E. PRUSSAK, George F. WIDHOPF, II
  • THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND METHODS FOR USE OF SAME
    Publication number: 20230341412
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Application
    Filed: November 22, 2022
    Publication date: October 26, 2023
    Inventors: Thomas J. KIPPS, George F. WIDHOPF, II, Bing CUI
  • CHIMERIC ANTIGEN RECEPTOR MODIFIED T-CELLS (CAR-T) FOR THE TREATMENT OF HEMATOLOGICAL AND SOLID TUMOR CANCERS
    Publication number: 20230312708
    Abstract: Provided herein is a chimeric antigen receptor (CAR) and CAR-expressing immune cells that target human RORI expressed aberrantly on a tumor cancers. Described herein are chimeric antigen receptors that target human ROR-1, cell compositions expressing the chimeric antigen receptors, and methods and uses of the chimeric antigen receptors and/or the cell compositions. The chimeric antigen receptors described herein can be expressed by the T lymphocytes isolated from an individual afflicted with cancer and re-administered to the individual.
    Type: Application
    Filed: March 26, 2020
    Publication date: October 5, 2023
    Inventors: Charles E. PRUSSAK, Thomas J. KIPPS, George F. WIDHOPF, II, Christopher S. OH
  • Therapeutic antibodies against ROR-1 protein and methods for use of same
    Patent number: 11536727
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Grant
    Filed: December 22, 2020
    Date of Patent: December 27, 2022
    Assignee: The Regents of the University of California
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • Antibodies and vaccines for use in treating ROR1 cancers and inhibiting metastasis
    Patent number: 11312787
    Abstract: The present invention relates to pharmaceutical compositions and a method of inhibiting metastasis using anti-ROR1 antibodies or antigen binding fragments, ROR1 binding peptides and ROR1 vaccines.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: April 26, 2022
    Assignee: The Regents of the University of California
    Inventors: Thomas James Kipps, Jian Yu, Bing Cui, Liguang Chen, George F. Widhopf, II, Charles Prussak
  • THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND METHODS FOR USE OF SAME
    Publication number: 20210208158
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Application
    Filed: December 22, 2020
    Publication date: July 8, 2021
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • Therapeutic antibodies against ROR-1 protein and methods for use of same
    Patent number: 10900973
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: January 26, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND METHODS FOR USE OF SAME
    Publication number: 20200309785
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Application
    Filed: January 30, 2020
    Publication date: October 1, 2020
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • Therapeutic antibodies against ROR-1 protein and methods for use of same
    Patent number: 10627409
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: April 21, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • ANTIBODIES AND VACCINES FOR USE IN TREATING ROR1 CANCERS AND INHIBITING METASTASIS
    Publication number: 20190389962
    Abstract: The present invention relates to pharmaceutical compositions and a method of inhibiting metastasis using anti-ROR1 antibodies or antigen binding fragments, ROR1 binding peptides and ROR1 vaccines.
    Type: Application
    Filed: May 14, 2019
    Publication date: December 26, 2019
    Inventors: Thomas James Kipps, Jian Yu, Bing Cui, Liguang Chen, George F. Widhopf, II, Charles Prussak
  • Antibodies and vaccines for use in treating ROR1 cancers and inhibiting metastasis
    Patent number: 10344096
    Abstract: The present invention relates to pharmaceutical compositions and a method of inhibiting metastasis using anti-ROR1 antibodies or antigen binding fragments, ROR1 binding peptides and ROR1 vaccines.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: July 9, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Thomas James Kipps, Jian Yu, Bing Cui, Liguang Chen, George F. Widhopf, II, Charles Prussak
  • THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND METHODS FOR USE OF SAME
    Publication number: 20180348232
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Application
    Filed: February 12, 2018
    Publication date: December 6, 2018
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • Therapeutic antibodies against ROR-1 protein and methods for use of same
    Patent number: 9933434
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: April 3, 2018
    Assignee: The Regents of the University of California
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • ANTIBODIES AND VACCINES FOR USE IN TREATING ROR1 CANCERS AND INHIBITING METASTASIS
    Publication number: 20180066063
    Abstract: The present invention relates to pharmaceutical compositions and a method of inhibiting metastasis using anti-ROR1 antibodies or antigen binding fragments, ROR1 binding peptides and ROR1 vaccines.
    Type: Application
    Filed: June 9, 2017
    Publication date: March 8, 2018
    Inventors: Thomas James Kipps, Jian Yu, Bing Cui, Liguang Chen, George F. Widhopf, II, Charles Prussak
  • Antibodies and vaccines for use in treating ROR1 cancers and inhibiting metastasis
    Patent number: 9758591
    Abstract: The present invention relates to pharmaceutical compositions and a method of inhibiting metastasis using anti-ROR1 antibodies or antigen binding fragments, ROR1 binding peptides and ROR1 vaccines.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 12, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Thomas James Kipps, Jian Yu, Bing Cui, Liguang Chen, George F. Widhopf, II, Charles Prussak
  • THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND METHODS FOR USE OF SAME
    Publication number: 20170248585
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Application
    Filed: November 9, 2016
    Publication date: August 31, 2017
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • Therapeutic antibodies against ROR-1 protein and methods for use of same
    Patent number: 9523695
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: December 20, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND METHODS FOR USE OF SAME
    Publication number: 20160097776
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Application
    Filed: September 4, 2015
    Publication date: April 7, 2016
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • Therapeutic antibodies against ROR-1 protein and methods for use of same
    Patent number: 9217040
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: December 22, 2015
    Assignee: The Regents of the University of California
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • Therapeutic Antibodies against ROR-1 Protein and Methods for Use of Same
    Publication number: 20130273073
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Application
    Filed: January 13, 2012
    Publication date: October 17, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui