Abstract: A disposable scope cleaning device and method of use are provided that allow obstructions on a distal viewing end of a medical scope encountered during an invasive medical procedure to be mechanically and fluidically removed in vivo. To achieve mechanical scrubbing and cleaning, the distal viewing end of the medical scope can be reciprocated or otherwise moved with respect to a cleaning member portion of the disposable scope cleaner. The disposable scope cleaner can include a system for flushing the distal end of the scope with an irrigation fluid. The disposable scope cleaner can be made from inexpensive, non-sterilizable materials, for example, non-autoclavable materials, so that the scope cleaner cannot be re-used and is therefore, disposable.