Patents by Inventor George Grills

George Grills has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biomolecular processing platform and uses thereof
    Patent number: 10870881
    Abstract: The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure within each bioreactor; a cleaving enzyme immobilized to the support structure and operatively positioned within the bioreactor chamber to cleave monomer or multimer units of a biopolymer molecule operatively engaged by the cleaving enzyme; and one or more time-of-flight channels formed in the solid substrate and fluidically coupled to said one or more bioreactor chambers. Each of the time-of-flight channels have two or more sensors including at least (i) a first sensor contacting the time-of-flight channel proximate to the input end of the channel and (ii) a second sensor contacting the time-of-flight channel proximate to the output end of channel. The present invention further relates to methods of sequencing and identifying biopolymer molecules using the device.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: December 22, 2020
    Assignees: CORNELL UNIVERSITY, UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, NORTHEASTERN UNIVERSITY, BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
    Inventors: Steven A. Soper, Francis Barany, George Grills, Robin McCarley, Collin J. McKinney, Dorel Moldovan, Michael C. Murphy, Dimitris Nikitopoulos, Sunggook Park, Elizabeth J. Podlaha-Murphy
  • BIOMOLECULAR PROCESSING PLATFORM AND USES THEREOF
    Publication number: 20180187257
    Abstract: The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure within each bioreactor; a cleaving enzyme immobilized to the support structure and operatively positioned within the bioreactor chamber to cleave monomer or multimer units of a biopolymer molecule operatively engaged by the cleaving enzyme; and one or more time-of-flight channels formed in the solid substrate and fluidically coupled to said one or more bioreactor chambers. Each of the time-of-flight channels have two or more sensors including at least (i) a first sensor contacting the time-of-flight channel proximate to the input end of the channel and (ii) a second sensor contacting the time-of-flight channel proximate to the output end of channel. The present invention further relates to methods of sequencing and identifying biopolymer molecules using the device.
    Type: Application
    Filed: February 19, 2018
    Publication date: July 5, 2018
    Inventors: Steven A. SOPER, Francis BARANY, George GRILLS, Robin McCARLEY, Collin J. McKINNEY, Doral MOLDOVAN, Michael C. MURPHY, Dimitris NIKITOPOULOS, Sunggook PARK, Elizabeth J. PODLAHA-MURPHY
  • Biomolecular processing platform and uses thereof
    Patent number: 9909173
    Abstract: The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure within each bioreactor; a cleaving enzyme immobilized to the support structure and operatively positioned within the bioreactor chamber to cleave monomer or multimer units of a biopolymer molecule operatively engaged by the cleaving enzyme; and one or more time-of-flight channels formed in the solid substrate and fluidically coupled to said one or more bioreactor chambers. Each of the time-of-flight channels have two or more sensors including at least (i) a first sensor contacting the time-of-flight channel proximate to the input end of the channel and (ii) a second sensor contacting the time-of-flight channel proximate to the output end of channel. The present invention further relates to methods of sequencing and identifying biopolymer molecules using the device.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: March 6, 2018
    Assignees: Cornell University, University of North Carolina at Chapel Hill, Northeastern University, Board of Supervisors of Louisiana State University and Agriculture and Mechanical College
    Inventors: Steven A. Soper, Francis Barany, George Grills, Robin McCarley, Collin J. McKinney, Dorel Moldovan, Michael C. Murphy, Dimitris Nikitopoulos, Sunggook Park, Elizabeth J. Podlaha-Murphy
  • Methods and devices for DNA sequencing and molecular diagnostics
    Patent number: 9670540
    Abstract: The present invention is directed to methods for capturing, amplifying and identifying one or more of a plurality of target nucleotide sequences in a sample. The present invention is further directed to a device comprising a solid support having a plurality of wells or pillars and a plurality of oligonucleotides attached to the wells or pillars. Other aspects of the invention are directed to methods of making such devices.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: June 6, 2017
    Assignees: Cornell University, Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Francis A. Barany, Steven A. Soper, George Grills, Yu-wei Cheng, Jianmin Huang, Hong Wang, Malgorzata A. Witek, Daniel Sang-won Park, Michael C. Murphy, Robin Lindsey McCarley, Mateusz L. Hupert
  • BIOMOLECULAR PROCESSING PLATFORM AND USES THEREOF
    Publication number: 20150361489
    Abstract: The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure within each bioreactor; a cleaving enzyme immobilized to the support structure and operatively positioned within the bioreactor chamber to cleave monomer or multimer units of a biopolymer molecule operatively engaged by the cleaving enzyme; and one or more time-of-flight channels formed in the solid substrate and fluidically coupled to said one or more bioreactor chambers. Each of the time-of-flight channels have two or more sensors including at least (i) a first sensor contacting the time-of-flight channel proximate to the input end of the channel and (ii) a second sensor contacting the time-of-flight channel proximate to the output end of channel. The present invention further relates to methods of sequencing and identifying biopolymer molecules using the device.
    Type: Application
    Filed: February 10, 2014
    Publication date: December 17, 2015
    Inventors: Steven A. SOPER, Francis BARANY, George GRILLS, Robin McCARLEY, Collin J. McKINNEY, Dorel MOLDOVAN, Michael C. MURPHY, Dimitris NIKITOPOULOS, Sunggook PARK, Elizabeth J. PODLAHA-MURPHY
  • METHODS AND DEVICES FOR DNA SEQUENCING AND MOLECULAR DIAGNOSTICS
    Publication number: 20150099642
    Abstract: The present invention is directed to methods for capturing, amplifying and identifying one or more of a plurality of target nucleotide sequences in a sample. The present invention is further directed to a device comprising a solid support having a plurality of wells or pillars and a plurality of oligonucleotides attached to the wells or pillars. Other aspects of the invention are directed to methods of making such devices.
    Type: Application
    Filed: July 23, 2012
    Publication date: April 9, 2015
    Applicants: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, CORNELL UNIVERSITY
    Inventors: Francis A. Barany, Steven A. Soper, George Grills, Yu-wei Cheng, Jianmin Huang, Malgorzata A. Witek, Daniel San-won Park, Michael C. Murphy, Robin Lindsey McCarley, Mateusz L. Hupert