Patents by Inventor George H. Buchi

George H. Buchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacture of quinone derivatives
    Patent number: 4853156
    Abstract: A novel process for the manufacture of quinone derivatives is described.In this process a compound of the formula ##STR1## is reacted with a compound of the formula ##STR2## and the resulting compound of the formula ##STR3## is subjected to a retro-Diels-Alder reaction. The substituents R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the significance given in the description.
    Type: Grant
    Filed: March 24, 1986
    Date of Patent: August 1, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: August Ruttimann, George H. Buchi
  • Process for the preparation of (.+-.)-3a-6,6,9a-tetramethylperhydronaphto[2,]furan
    Patent number: 4677233
    Abstract: 3a,6,6,9a-Tetramethylperhydronaphto[2,1-b]furan, a typical ambergris perfume ingredient is prepared via a novel process from 1.beta.-(2-hydroxyethyl)-perhydro-2,5,5,8a.beta.-tetramethyl-2.beta.-trans -napthalenol by cyclization with an acidic cyclization agent in the presence of nitromethane.
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: June 30, 1987
    Assignee: Firmenich SA
    Inventors: George H. Buchi, Hans Wuest
  • Process for the preparation of (.+-.)-3a-6,6,9a-tetramethylperhydronaphto[2,]furan
    Patent number: 4633011
    Abstract: 3a,6,6,9a-Tetramethylperhydronaphto[2,1-b]furan, a typical ambergris perfume ingredient is prepared via a novel process from 1.beta.-(2-hydroxyethyl)-perhydro-2,5,5,8a.beta.-tetramethyl-2.beta.-trans -naphthalenol by cyclization with an acidic cyclization agent in the presence of nitromethane.
    Type: Grant
    Filed: March 10, 1986
    Date of Patent: December 30, 1986
    Assignee: Firmenich SA
    Inventors: George H. Buchi, Hans Wuest
  • Process for the preparation of (.+-.)-3a-6,6,9a-tetramethylperhydronaphto[2,]furan
    Patent number: 4613710
    Abstract: 3a,6,6,9a-Tetramethylperhydronaphto[2,1-b]furan, a typical ambergris perfume ingredient is prepared via a novel process from 1.beta.-(2-hydroxyethyl)-perhydro-2,5,5,8a.beta.-tetramethyl-2.beta.-trans -naphthalenol by cyclization with an acidic cyclization agent in the presence of nitromethane.
    Type: Grant
    Filed: August 8, 1984
    Date of Patent: September 23, 1986
    Assignee: Firmenich SA
    Inventors: George H. Buchi, Hans Wuest
  • Process for the manufacture of quinone derivatives
    Patent number: 4603223
    Abstract: A novel process for the manufacture of quinone derivatives is described.In this process a compound of the formula ##STR1## is reacted with a compound of the formula ##STR2## and the resulting compound of the formula ##STR3## is subjected to a retro-Diels-Alder reaction. The substituents R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the significance given in the description.
    Type: Grant
    Filed: July 24, 1984
    Date of Patent: July 29, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: August Ruttimann, George H. Buchi
  • Process for the preparation of novel unsaturated macrocyclic ketones
    Patent number: 4346023
    Abstract: New unsaturated macrocyclic ketones are obtained via a process which consists in reacting a dialdehyde with a tetraalkyldiphosphonate ester. The new ketones are useful intermediates for the preparation of cyclopentadecanone and its higher methyl-homologue, known fragrant substances. New ketones possess also direct utility as musky odorants.
    Type: Grant
    Filed: March 17, 1981
    Date of Patent: August 24, 1982
    Assignee: Firmenich SA
    Inventors: George H. Buchi, Hans Wuest
  • Process for the preparation of novel unsaturated macrocyclic ketones
    Patent number: 4302607
    Abstract: New unsaturated macrocyclic ketones are obtained via a process which consists in reacting a dialdehyde with a tetraalkyldiphosphonate ester. The new ketones are useful intermediates for the preparation of cyclopentadecanone and its higher methyl-homologue, known fragrant substances. New ketones possess also direct utility as musky odorants.
    Type: Grant
    Filed: September 19, 1979
    Date of Patent: November 24, 1981
    Assignee: Firmenich SA
    Inventors: George H. Buchi, Hans Wuest
  • Process for the preparation of macrocyclic ketones
    Patent number: 4296258
    Abstract: New process for the preparation of acetylenic macrocyclic ketones, which compounds represent useful intermediates for the synthesis of valuable perfuming ingredients, viz. muscone and EXALTONE.RTM. (cyclopentadecanone).
    Type: Grant
    Filed: December 28, 1979
    Date of Patent: October 20, 1981
    Assignee: Firmenich SA
    Inventors: Charles Fehr, Gunther Ohloff, Georges H. Buchi
  • 9-Hydroxy-undeca-4,10-dien-1-al
    Patent number: 4271048
    Abstract: 9-Hydroxy-undeca-4,10-dien-1-al, a novel unsaturated aliphatic hydroxy-aldehyde, has been found to possess useful odorous properties and consequently can be advantageously used as perfume ingredient.
    Type: Grant
    Filed: August 11, 1980
    Date of Patent: June 2, 1981
    Assignee: Firmenich, S.A.
    Inventors: George H. Buchi, Hans Wuest
  • 6,6,7-Trimethyl-tricyclo[5.2.2.0.sup.1,5 ]undec-8-en-2-one
    Patent number: 4124642
    Abstract: Novel tricyclo-ketone derivatives useful as perfume ingredients and as intermediates for the preparation of (.+-.) khusimone.
    Type: Grant
    Filed: September 19, 1977
    Date of Patent: November 7, 1978
    Assignee: Firmenich, S.A.
    Inventors: George H. Buchi, Arnold Hauser
  • Cycloaliphatic unsaturated ketones as fragrance modifying agents
    Patent number: 4028278
    Abstract: New cycloaliphatic unsaturated ketones and their use as perfuming and odor-modifying agents in the manufacture of perfumes and perfumed products, and as flavoring and taste-modifying agents in the preparation of foodstuffs in general and imitation flavors for foodstuffs, beverages, animal feeds, pharmaceutical preparations and tobacco products.Methods for preparing the said new compounds and certain of the starting materials used for their synthesis.
    Type: Grant
    Filed: May 6, 1976
    Date of Patent: June 7, 1977
    Assignee: Firmenich S.A.
    Inventors: George H. Buchi, Hans Wuest
  • Process for the preparation of unsaturated aldehydes
    Patent number: 3974225
    Abstract: Process for the preparation of unsaturated aldehydes, in particular .gamma.,.delta.-unsaturated aldehydes, which comprises reacting an amino-nitrile with a basic or a neutral agent.The products obtained in accordance with the process of the invention are useful intermediates for the preparation of flavoring ingredients.
    Type: Grant
    Filed: June 5, 1974
    Date of Patent: August 10, 1976
    Assignee: Firmenich S.A.
    Inventors: George H. Buchi, Hans Wuest
  • Preparation of polyenes
    Patent number: 3932546
    Abstract: Polyenes are synthesized from unsaturated materials having allylic hydroxyl groups, which react with imidosulfides to produce sulfones. Removal of the sulfone group, e.g. by reaction with alkyllithium and iodine, results in compounds in which the allylic carbons are joined by a double bond. The reactions take place easily over wide temperature ranges. The method is particularly advantageous in the synthesis of carotenoids from polyene alcohols, being much simpler and easier to use than previous carotenoid syntheses.
    Type: Grant
    Filed: February 8, 1974
    Date of Patent: January 13, 1976
    Assignee: Massachusetts Institute of Technology
    Inventors: George H. Buchi, Roger M. Freidinger