Patents by Inventor George H. Douglas

George H. Douglas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic alkylene triazinones
    Patent number: 4387225
    Abstract: Heterocyclic alkyl s-triazine compounds are prepared from the corresponding amidinourea and amidinothiourea compounds by reacting with an activated form of an acid amide to give respectively substituted s-triazinones and thiones of the formula ##STR1## which have pharmacological properties that render them suitable for use for a variety of medicinal purposes, including use as antidiarrheal agents, and which are also useful derivatives in analyzing for the corresponding amidinourea or amidinothiourea precursors.
    Type: Grant
    Filed: May 12, 1981
    Date of Patent: June 7, 1983
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, William L. Studt, Chong M. Won, Stuart A. Dodson, Jerome J. Zalipsky
  • Amidinoureas
    Patent number: 4353842
    Abstract: A novel method of treating gastrointestinal, spasmolytic and ulcerogenic disorders by the administration of amidinoureas is disclosed.
    Type: Grant
    Filed: February 5, 1980
    Date of Patent: October 12, 1982
    Assignee: William H. Rorer, Inc.
    Inventors: Julius Diamond, George H. Douglas
  • Triazinones
    Patent number: 4338441
    Abstract: Novel s-triazine compounds are prepared as derivatives of the corresponding amidinourea and amidinothiourea compounds by reacting with an activated form of an acid amide to give substituted s-triazinones and thiones respectively, of the formula ##STR1## The s-triazinones and thiones are useful derivatives in analyzing for the corresponding amidinourea or amidinothiourea precursors and also have useful pharmacological properties which make them suitable for a variety of medicinal purposes including use as antidiarrheal agents.
    Type: Grant
    Filed: January 15, 1981
    Date of Patent: July 6, 1982
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, William L. Studt, Chong M. Won, Stuart A. Dodson, Jerome J. Zalipsky
  • Amidinoureas
    Patent number: 4326075
    Abstract: A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-diarrheal agents.
    Type: Grant
    Filed: February 5, 1980
    Date of Patent: April 20, 1982
    Assignee: William H. Rorer, Inc.
    Inventors: Julius Diamond, George H. Douglas
  • Amidinoureas
    Patent number: 4326074
    Abstract: A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-diarrheal agents.
    Type: Grant
    Filed: December 18, 1979
    Date of Patent: April 20, 1982
    Assignee: William H. Rorer, Inc.
    Inventors: Julius Diamond, George H. Douglas
  • Amidinoureas
    Patent number: 4304786
    Abstract: A novel method of treating gastrointestinal, spasmolytic and ulcerogenic disorders by the administration of amidinoureas is disclosed.
    Type: Grant
    Filed: July 23, 1979
    Date of Patent: December 8, 1981
    Assignee: William H. Rorer, Inc.
    Inventors: Julius Diamond, George H. Douglas
  • Method for blocking high frequency nerve stimulation
    Patent number: 4298608
    Abstract: 1,4-Disubstituted-1,2-dihydro-1,3,5-triazin-2-ones are used to block conduction of high frequency nerve impulses by selectively acting to substantially completely block high frequency impulses without significantly blocking conduction of a single impulse. The effect is reversible when the drug is withdrawn.
    Type: Grant
    Filed: April 11, 1980
    Date of Patent: November 3, 1981
    Assignee: William H. Rorer, Inc.
    Inventors: George A. Condouris, John Yelnosky, Richard L. Riley, Chong M. Won, George H. Douglas, William L. Studt
  • Method of lowering blood pressure
    Patent number: 4279928
    Abstract: Multiple daily dosing with amidinoureas of the formula ##STR1## produces a significant and sustained decrease in blood pressure in humans.
    Type: Grant
    Filed: April 2, 1979
    Date of Patent: July 21, 1981
    Assignee: William H. Rorer, Inc.
    Inventors: Richard L. Riley, George H. Douglas, John Yelnosky
  • Process for producing ethynylbenzenes
    Patent number: 4267388
    Abstract: There is disclosed a novel process for preparing anti-inflammatory ethynylbenzene derivatives represented by the general formula I: ##STR1## wherein Y is hydrogen, halogen or loweralkyl of 1 to 3 carbon atoms; R represents a ring having the structure: ##STR2## wherein x is 1 to 3, or a ring of the structure: ##STR3## wherein Y' is hydrogen, halogen, loweralkyl of 1 to 3 carbon atoms and loweralkoxy of 1 to 3 carbon atoms; Y" is hydrogen or halogen; and Y"' is hydrogen or halogen, provided Y, Y', Y" and Y"' are not all hydrogen at the same time, by reacting a benzyl alcohol of formula V: ##STR4## with a sulfonyl chloride, reducing the sulfonate VI of the formula: ##STR5## and dehydrohalogenating the formed .beta.
    Type: Grant
    Filed: July 12, 1979
    Date of Patent: May 12, 1981
    Assignee: William H. Rorer, Inc.
    Inventors: Paul R. Darkes, Henry F. Campbell, George H. Douglas
  • Triazinones
    Patent number: 4246409
    Abstract: Novel s-triazine compounds are prepared as derivatives of the corresponding amidinourea and amidinothiourea compounds by reacting with an activated form of an acid amide to give substituted s-triazinones and thiones respectively, of the formula ##STR1## The s-triazinones and thiones are useful derivatives in analyzing for the corresponding amidinourea or amidino thiourea precursors and also have useful pharmacological properties which make them suitable for a variety of medicinal purposes including use as antidiarrheal agents.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: January 20, 1981
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, William L. Studt, Chong M. Won, Stuart A. Dodson, Jerome J. Zalipsky
  • Method for treatment of diarrheal disease conditions or symptons in mammals
    Patent number: 4242337
    Abstract: A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: December 30, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, William L. Studt, Stuart A. Dodson
  • Method for the treatment of diarrheal disease conditions and symptoms in mammals
    Patent number: 4242340
    Abstract: A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: December 30, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, William L. Studt, Stuart A. Dodson
  • Method for treatment of gastrointestinal secretory and ulcerogenic disease conditions or symptoms in mammals
    Patent number: 4242338
    Abstract: A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: December 30, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, William L. Studt, Stuart A. Dodson
  • Method for treatment of gastrointestinal spasmodic disease conditions or symptoms in mammals
    Patent number: 4242339
    Abstract: A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: December 30, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, William L. Studt, Stuart A. Dodson
  • Method of treatment
    Patent number: 4235929
    Abstract: This invention describes a method of treating inflammation in warm blooded animals by topically administering an effective amount of benzylideneaniline or its derivatives.
    Type: Grant
    Filed: March 2, 1979
    Date of Patent: November 25, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George W. Nuss, Jr., Norman J. Santora, George H. Douglas
  • Compositions and method of treatment
    Patent number: 4230727
    Abstract: Compositions for inhibiting cellular proliferation in mammals containing as the active ingredient N-benzylideneaniline and its derivatives, and the method therefor.
    Type: Grant
    Filed: April 2, 1979
    Date of Patent: October 28, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George W. Nuss, Jr., Norman J. Santora, George H. Douglas
  • Anti-inflammatory compositions containing .alpha.-phenyl-N-phenylnitrone compounds
    Patent number: 4224340
    Abstract: This invention relates to novel compositions containing .alpha.-phenyl-n-phenylnitrone compounds which are useful for the topical treatment of inflammation in warm-blooded animals.
    Type: Grant
    Filed: March 15, 1979
    Date of Patent: September 23, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: Henry F. Campbell, Norman F. Santora, George H. Douglas
  • Treatment of hypertension with amidinoureas
    Patent number: 4220658
    Abstract: Novel phenylamidinourea compounds and processes for their preparation are described. These compounds have an effective degree of anti-hypertensive properties and exert activities on the cardiovascular system. A method for the treatment of hypertensive disorders is also described.
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: September 2, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, Julius Diamond
  • Method for treatment of gastrointestinal spasmodic disease conditions or symptoms in mammals
    Patent number: 4218450
    Abstract: A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: August 19, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, William L. Studt, Stuart A. Dodson
  • Method of treatment
    Patent number: 4214003
    Abstract: This invention describes a method of treating inflammation in warm-blooded animals by topically administering an effective amount of .alpha.-phenyl-N-phenylnitrone and derivatives thereof.
    Type: Grant
    Filed: October 3, 1978
    Date of Patent: July 22, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: Henry F. Campbell, Norman J. Santora, George H. Douglas