Patents by Inventor George H. Hitchings

George H. Hitchings has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adenosine deaminase inhibitors
    Patent number: 4315920
    Abstract: Pharmaceutical preparations containing compounds of the formula ##STR1## where R is alkyl of 1 to 11 carbons. The preparations are useful in inhibiting adenosine deaminase in mammals thereby providing a method for prolonging the effectiveness of pharamaceutical agents which are biologically degraded by adenosine deaminase and thus converted into other compounds.
    Type: Grant
    Filed: January 14, 1980
    Date of Patent: February 16, 1982
    Assignee: Burroughs Wellcome Co.
    Inventors: Howard J. Schaeffer, Paulo M. S. DeMiranda, Gertrude B. Elion, George H. Hitchings
  • Treating CNS lymphoma
    Patent number: 4006235
    Abstract: Method and pharmaceutical preparations for treating meningeal leukemia, CNS lymphoma and neoplasms in the brain which comprises treating an infected mammal such as a human with a dose of an effective treatment amount of a compound of Formula I ##STR1## where R is a straight or branched chain lower alkyl of 1 to 4 carbon atoms, and X is a halogen atom (fluorine, chlorine, bromine or iodine) and pharmaceutically acceptable salts thereof.Preferred compounds for treatment of the aforementioned diseases are 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methyl-pyrimidine and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-ethyl-pyrimidine.
    Type: Grant
    Filed: February 12, 1975
    Date of Patent: February 1, 1977
    Assignee: Burroughs Wellcome Co.
    Inventors: Dwight R. Stickney, William S. Simmons, Charles A. Nichol, George H. Hitchings, Gertrude B. Elion
  • Treatment of neoplasms in the brain with diamino dichloroalkyl pyrimidine
    Patent number: 4005204
    Abstract: Method and pharmaceutical preparations for treating meningeal leukemia, CNS Iymphoma and neoplasms in the brain which comprises treating an infected mammal such as a human with a dose of an effective treatment amount of a compound of Formula I ##STR1## where R is a straight or branched chain lower alkyl of 1 to 4 carbon atoms, and X is a halogen atom (fluorine, chlorine, bromine or iodine) and pharmaceutically acceptable salts thereof.Preferred compounds for treatment of the aforementioned diseases are 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-ethylpyrimidine.
    Type: Grant
    Filed: February 12, 1975
    Date of Patent: January 25, 1977
    Assignee: Burroughs Wellcome Co.
    Inventors: Dwight R. Stickney, William S. Simmons, Charles A. Nichol, George H. Hitchings, Gertrude B. Elion
  • Treatment of meningeal leukemia with diamino dichlorophenyl pyrimidine
    Patent number: 4005203
    Abstract: Method and pharmaceutical preparations for treating meningeal leukemia, CNS Iymphoma and neoplasma in the brain which comprises treating an infected mammal such as a human with a dose of an effective treatment amount of a compound of Formula I ##STR1## where R is a straight or branched chain lower alkyl of 1 to 4 carbon atoms, and X is a halogen atom (fluorine, chlorine, bromine or iodine) and pharmaceutically acceptable salts thereof.Preferred compounds for treatment of the aforementioned diseases are 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-ethylpyrimidine.
    Type: Grant
    Filed: February 12, 1975
    Date of Patent: January 25, 1977
    Assignee: Burroughs Wellcome Co.
    Inventors: Dwight R. Stickney, William S. Simmons, Charles A. Nichol, George H. Hitchings, Gertrude B. Elion