Abstract: The present invention refers to a sterile barrier system composed of: a minimum of one external 100% polypropylene SMS sheet with hydrophobic treatment (water repellent), providing a microbial barrier for bacterial and viral filtration efficiency (BFE and VFE), which meets the requirements of non aqueous propagation of microorganisms or recontamination of the packaging; and a minimum of one internal 100% polypropylene SMS sheet with hydrophilic treatment, that absorbs the excess vapor from inside the packaging and dissipates it by controlled porosity in the autoclave vacuum, under high temperature. This combined hydrophilic and hydrophobic system enhances effectively the performance of the drying cycle in the autoclave, obtaining dry packaging after the sterilization cycle, eliminating the risks of recontamination, preserving the sterility of the packages and reducing costs in the operation.