Patents by Inventor George Harb
George Harb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 12215355Abstract: Provided herein are methods of producing ? cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.Type: GrantFiled: February 9, 2021Date of Patent: February 4, 2025Assignee: Vertex Pharmaceuticals IncorporatedInventors: Felicia J. Pagliuca, George Harb, Lillian Ye
-
Patent number: 12195765Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: GrantFiled: March 27, 2023Date of Patent: January 14, 2025Assignee: Cellino Biotech, Inc.Inventors: Matthias Wagner, Suvi Aivio, Mariangela Amenduni, Catherine Pilsmaker, Arnaldo Pereira, Ananya Zutshi, Anthia Toure, Steven Nagle, Ozge Whiting, George Harb, Matthew Sullivan, Maya Berlin-Udi, Stefanie Morgan, Nick Seay, Sang Lee, Scott Luro
-
Publication number: 20250011723Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: ApplicationFiled: September 4, 2024Publication date: January 9, 2025Applicant: Vertex Pharmaceuticals IncorporatedInventors: George Harb, Chunhi Xie
-
Publication number: 20240425818Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: ApplicationFiled: September 4, 2024Publication date: December 26, 2024Applicant: Vertex Pharmaceuticals IncorporatedInventors: George Harb, Chunhi Xie
-
Patent number: 12173327Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: GrantFiled: June 22, 2023Date of Patent: December 24, 2024Assignee: Cellino Biotech, Inc.Inventors: Matthias Wagner, Suvi Aivio, Mariangela Amenduni, Catherine Pilsmaker, Arnaldo Pereira, Ananya Zutshi, Anthia Toure, Steven Nagle, Ozge Whiting, George Harb, Matthew Sullivan, Maya Berlin-Udi, Stefanie Morgan, Nick Seay, Sang Lee, Scott Luro
-
Patent number: 12173324Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: GrantFiled: November 16, 2022Date of Patent: December 24, 2024Assignee: Vertex Pharmaceuticals IncorporatedInventors: George Harb, Chunhui Xie
-
Publication number: 20240382532Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: ApplicationFiled: April 26, 2024Publication date: November 21, 2024Applicant: Vertex Pharmaceuticals IncorporatedInventors: George Harb, Chunhui Xie, Bryce W. Carey, Aleksander Szymaniak, Christopher Thanos, Evrett Thompson, Rebecca Chinn, Suyash Raj
-
Publication number: 20240358767Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro in the presence of one or more chemical compounds that inhibit PI3K/Akt/mTOR signaling. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of making use thereof.Type: ApplicationFiled: November 7, 2022Publication date: October 31, 2024Applicant: VERTEX PHARMACEUTICALS INCORPORATEDInventors: Chunhui XIE, George HARB, Elizabeth RYU, Nicholas TECENO, Christopher FARRAR
-
Publication number: 20240271100Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: ApplicationFiled: July 30, 2021Publication date: August 15, 2024Applicant: VERTEX PHARMACEUTICALS INCORPORATEDInventors: George HARB, Chunhui XIE
-
Publication number: 20240253032Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: ApplicationFiled: December 20, 2023Publication date: August 1, 2024Inventors: Matthias WAGNER, Suvi AIVIO, Mariangela AMENDUNI, Catherine PILSMAKER, Arnaldo PEREIRA, Ananya ZUTSHI, Ozge WHITING, George HARB, Steven NAGLE, Anthia TOURE, Matthew SULLIVAN, Maya BERLIN-UDI, Lukas VASADI, Alexander STANGE, Sangkyun LEE, Stefanie MORGAN, Nick SEAY, Scott LURO
-
Patent number: 12049645Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: GrantFiled: July 30, 2021Date of Patent: July 30, 2024Inventors: George Harb, Chunhui Xie
-
Publication number: 20240240153Abstract: The present application discloses cell clusters resembling the function and characteristics of endogenous pancreatic islets, and methods for making and using such cell clusters.Type: ApplicationFiled: December 21, 2023Publication date: July 18, 2024Applicant: Vertex Pharmaceuticals IncorporatedInventors: Yeh-Chuin POH, George HARB, Felicia J. PAGLIUCA
-
Publication number: 20240191204Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: ApplicationFiled: December 20, 2023Publication date: June 13, 2024Inventors: Matthias WAGNER, Suvi AIVIO, Mariangela AMENDUNI, Catherine PILSMAKER, Arnaldo PEREIRA, Ananya ZUTSHI, Anthia TOURE, Steven NAGLE, Ozge WHITING, George HARB, Matthew SULLIVAN, Maya BERLIN-UDI, Stefanie MORGAN, Nick SEAY, Sang LEE, Scott LURO
-
Patent number: 12006516Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: GrantFiled: December 21, 2023Date of Patent: June 11, 2024Assignee: Vertex Pharmaceuticals IncorporatedInventors: George Harb, Chunhi Xie
-
Patent number: 11999971Abstract: Provided herein are methods of producing ? cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.Type: GrantFiled: November 14, 2022Date of Patent: June 4, 2024Assignee: VERTEX PHARMACEUTICALS INCORPORATEDInventors: Felicia J. Pagliuca, George Harb, Lillian Ye
-
Patent number: 11992506Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: GrantFiled: November 1, 2022Date of Patent: May 28, 2024Assignee: VERTEX PHARMACEUTICALS INCORPORATEDInventors: George Harb, Chunhui Xie, Bryce W. Carey, Aleksander Szymaniak, Christopher Thanos, Evrett Thompson, Rebecca Chinn, Suyash Raj
-
Publication number: 20240117319Abstract: The present application discloses cell clusters resembling the function and characteristics of endogenous pancreatic islets, and methods for making and using such cell clusters.Type: ApplicationFiled: December 21, 2023Publication date: April 11, 2024Applicant: Vertex Pharmaceuticals IncorporatedInventors: Yeh-Chuin POH, George HARB, Felicia J. PAGLIUCA
-
Publication number: 20240117318Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: ApplicationFiled: December 21, 2023Publication date: April 11, 2024Applicant: Vertex Pharmaceuticals IncorporatedInventors: George Harb, Chunhi Xie
-
Patent number: 11931737Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: GrantFiled: September 7, 2022Date of Patent: March 19, 2024Assignee: CELLINO BIOTECH, INC.Inventors: Matthias Wagner, Suvi Aivio, Mariangela Amenduni, Catherine Pilsmaker, Arnaldo Pereira, Ananya Zutshi, Ozge Whiting, George Harb, Steven Nagle, Anthia Toure, Matthew Sullivan, Maya Berlin-Udi, Lukas Vasadi, Alexander Stange, Sangkyun Lee, Stefanie Morgan, Nick Seay, Scott Luro
-
Patent number: 11913029Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: GrantFiled: December 5, 2022Date of Patent: February 27, 2024Assignee: CELLINO BIOTECH, INC.Inventors: Matthias Wagner, Suvi Aivio, Mariangela Amenduni, Catherine Pilsmaker, Arnaldo Pereira, Ananya Zutshi, Anthia Toure, Steven Nagle, Ozge Whiting, George Harb, Matthew Sullivan, Maya Berlin-Udi, Stefanie Morgan, Nick Seay, Sang Lee, Scott Luro