Patents by Inventor George Harb

George Harb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12215355
    Abstract: Provided herein are methods of producing ? cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.
    Type: Grant
    Filed: February 9, 2021
    Date of Patent: February 4, 2025
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Felicia J. Pagliuca, George Harb, Lillian Ye
  • Patent number: 12195765
    Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.
    Type: Grant
    Filed: March 27, 2023
    Date of Patent: January 14, 2025
    Assignee: Cellino Biotech, Inc.
    Inventors: Matthias Wagner, Suvi Aivio, Mariangela Amenduni, Catherine Pilsmaker, Arnaldo Pereira, Ananya Zutshi, Anthia Toure, Steven Nagle, Ozge Whiting, George Harb, Matthew Sullivan, Maya Berlin-Udi, Stefanie Morgan, Nick Seay, Sang Lee, Scott Luro
  • Publication number: 20250011723
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Application
    Filed: September 4, 2024
    Publication date: January 9, 2025
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: George Harb, Chunhi Xie
  • Publication number: 20240425818
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Application
    Filed: September 4, 2024
    Publication date: December 26, 2024
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: George Harb, Chunhi Xie
  • Patent number: 12173327
    Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.
    Type: Grant
    Filed: June 22, 2023
    Date of Patent: December 24, 2024
    Assignee: Cellino Biotech, Inc.
    Inventors: Matthias Wagner, Suvi Aivio, Mariangela Amenduni, Catherine Pilsmaker, Arnaldo Pereira, Ananya Zutshi, Anthia Toure, Steven Nagle, Ozge Whiting, George Harb, Matthew Sullivan, Maya Berlin-Udi, Stefanie Morgan, Nick Seay, Sang Lee, Scott Luro
  • Patent number: 12173324
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Grant
    Filed: November 16, 2022
    Date of Patent: December 24, 2024
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: George Harb, Chunhui Xie
  • Publication number: 20240382532
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Application
    Filed: April 26, 2024
    Publication date: November 21, 2024
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: George Harb, Chunhui Xie, Bryce W. Carey, Aleksander Szymaniak, Christopher Thanos, Evrett Thompson, Rebecca Chinn, Suyash Raj
  • Publication number: 20240358767
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro in the presence of one or more chemical compounds that inhibit PI3K/Akt/mTOR signaling. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of making use thereof.
    Type: Application
    Filed: November 7, 2022
    Publication date: October 31, 2024
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Chunhui XIE, George HARB, Elizabeth RYU, Nicholas TECENO, Christopher FARRAR
  • Publication number: 20240271100
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Application
    Filed: July 30, 2021
    Publication date: August 15, 2024
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: George HARB, Chunhui XIE
  • Publication number: 20240253032
    Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.
    Type: Application
    Filed: December 20, 2023
    Publication date: August 1, 2024
    Inventors: Matthias WAGNER, Suvi AIVIO, Mariangela AMENDUNI, Catherine PILSMAKER, Arnaldo PEREIRA, Ananya ZUTSHI, Ozge WHITING, George HARB, Steven NAGLE, Anthia TOURE, Matthew SULLIVAN, Maya BERLIN-UDI, Lukas VASADI, Alexander STANGE, Sangkyun LEE, Stefanie MORGAN, Nick SEAY, Scott LURO
  • Patent number: 12049645
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: July 30, 2024
    Inventors: George Harb, Chunhui Xie
  • Publication number: 20240240153
    Abstract: The present application discloses cell clusters resembling the function and characteristics of endogenous pancreatic islets, and methods for making and using such cell clusters.
    Type: Application
    Filed: December 21, 2023
    Publication date: July 18, 2024
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Yeh-Chuin POH, George HARB, Felicia J. PAGLIUCA
  • Publication number: 20240191204
    Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.
    Type: Application
    Filed: December 20, 2023
    Publication date: June 13, 2024
    Inventors: Matthias WAGNER, Suvi AIVIO, Mariangela AMENDUNI, Catherine PILSMAKER, Arnaldo PEREIRA, Ananya ZUTSHI, Anthia TOURE, Steven NAGLE, Ozge WHITING, George HARB, Matthew SULLIVAN, Maya BERLIN-UDI, Stefanie MORGAN, Nick SEAY, Sang LEE, Scott LURO
  • Patent number: 12006516
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Grant
    Filed: December 21, 2023
    Date of Patent: June 11, 2024
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: George Harb, Chunhi Xie
  • Patent number: 11999971
    Abstract: Provided herein are methods of producing ? cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.
    Type: Grant
    Filed: November 14, 2022
    Date of Patent: June 4, 2024
    Assignee: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Felicia J. Pagliuca, George Harb, Lillian Ye
  • Patent number: 11992506
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Grant
    Filed: November 1, 2022
    Date of Patent: May 28, 2024
    Assignee: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: George Harb, Chunhui Xie, Bryce W. Carey, Aleksander Szymaniak, Christopher Thanos, Evrett Thompson, Rebecca Chinn, Suyash Raj
  • Publication number: 20240117319
    Abstract: The present application discloses cell clusters resembling the function and characteristics of endogenous pancreatic islets, and methods for making and using such cell clusters.
    Type: Application
    Filed: December 21, 2023
    Publication date: April 11, 2024
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Yeh-Chuin POH, George HARB, Felicia J. PAGLIUCA
  • Publication number: 20240117318
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Application
    Filed: December 21, 2023
    Publication date: April 11, 2024
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: George Harb, Chunhi Xie
  • Patent number: 11931737
    Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.
    Type: Grant
    Filed: September 7, 2022
    Date of Patent: March 19, 2024
    Assignee: CELLINO BIOTECH, INC.
    Inventors: Matthias Wagner, Suvi Aivio, Mariangela Amenduni, Catherine Pilsmaker, Arnaldo Pereira, Ananya Zutshi, Ozge Whiting, George Harb, Steven Nagle, Anthia Toure, Matthew Sullivan, Maya Berlin-Udi, Lukas Vasadi, Alexander Stange, Sangkyun Lee, Stefanie Morgan, Nick Seay, Scott Luro
  • Patent number: 11913029
    Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.
    Type: Grant
    Filed: December 5, 2022
    Date of Patent: February 27, 2024
    Assignee: CELLINO BIOTECH, INC.
    Inventors: Matthias Wagner, Suvi Aivio, Mariangela Amenduni, Catherine Pilsmaker, Arnaldo Pereira, Ananya Zutshi, Anthia Toure, Steven Nagle, Ozge Whiting, George Harb, Matthew Sullivan, Maya Berlin-Udi, Stefanie Morgan, Nick Seay, Sang Lee, Scott Luro