Patents by Inventor George Holan
George Holan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8158575Abstract: Use of a polylysine, polyamidoamine or polypropylenimine dendrimer having naphthyl disulphonate terminal groups as a topically applied agent in prophylaxis or treatment of sexually transmitted diseases.Type: GrantFiled: July 6, 2009Date of Patent: April 17, 2012Assignee: Starpharma Pty., LtdInventors: Barry Ross Matthews, George Holan, Peter Karellas, Scott Andrew Henderson, David Francis O'Keefe
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Publication number: 20090269298Abstract: Use of a polylysine, polyamidoamine or polypropylenimine dendrimer having naphthyl disulphonate terminal groups as a topically applied agent in prophylaxis or treatment of sexually transmitted diseases.Type: ApplicationFiled: July 6, 2009Publication date: October 29, 2009Inventors: Barry Ross MATTHEWS, George HOLAN, Peter KARELLAS, Scott Andrew HENDERSON, David Francis O'KEEFE
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Patent number: 7589056Abstract: Use of a polylysine, polyamidoamine or polypropylenimine dendrimer having naphthyl disulphonate terminal groups as a topically applied agent in prophylaxis or treatment of sexually transmitted diseases.Type: GrantFiled: March 28, 2002Date of Patent: September 15, 2009Assignee: Starpharma Pty. Ltd.Inventors: Barry Ross Matthews, George Holan, Peter Karellas, Scott Andrew Henderson, David Francis O'Keefe
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Patent number: 7572459Abstract: To inhibit, prophylactically or therapeutically, a bacterial, yeast, fungal, or parasitic agent in a patient, an effective amount of a dendrimer is administered to the patient, which dendrimer has a plurality of terminal groups, at least one of which has an anionic- or cationic-moiety covalently bonded or linked thereto. The anionic-containing moiety is not a disaccharide or oligosaccharide moiety, and, where the anionic-containing moiety is a neuraminic- or sialic acid-containing moiety, it is modified in the 4-position by substitution with an amino, amido, cyano, azido or guanido group, or is unsaturated.Type: GrantFiled: August 26, 2002Date of Patent: August 11, 2009Assignee: Starpharma Pty Ltd.Inventors: Barry Ross Matthews, George Holan
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Publication number: 20050038248Abstract: The invention provides 1,2-substituted cyclic compounds useful for treatment of diseases or disorders arising from abnormal or inappropriate cell proliferation, such as tumour growth, tumour metastasis and associated angiogenesis, as well as pharmaceutical compositions comprising these compounds and their use in methods of treatment.Type: ApplicationFiled: August 29, 2002Publication date: February 17, 2005Inventors: Scott Henderson, George Holan, Barry Matthews
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Publication number: 20050008611Abstract: Use of a polylysine, polyamidoamine or polypropylenimine dendrimer having naphthyl disulphonate terminal groups as a topically applied agent in prophylaxis or treatment of sexually transmitted diseases.Type: ApplicationFiled: March 28, 2002Publication date: January 13, 2005Inventors: Barry Matthews, George Holan, Peter Karellas, Scott Henderson, David O'Keefe
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Patent number: 6740635Abstract: An antiviral compound comprises a linear non-carbohydrate polymer having a plurality of side chain groups, wherein at least one of the side chain groups has an anionic- or cationic-containing moiety bonded or linked thereto.Type: GrantFiled: August 15, 2001Date of Patent: May 25, 2004Assignee: Biomolecular Research Institute Ltd.Inventors: Barry Ross Matthews, George Holan
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Publication number: 20030129158Abstract: To inhibit, prophylactically or therapeutically, a bacterial, yeast, fungal, or parasitic agent in a patient, an effective amount of a dendrimer is administered to the patient, which dendrimer has a plurality of terminal groups, at least one of which has an anionic- or cationic-moiety covalently bonded or linked thereto. The anionic-containing moiety is not a disaccharide or oligosaccharide moiety, and, where the anionic-containing moiety is a neuraminic- or sialic acid-containing moiety, it is modified in the 4-position by substitution with an amino, amido, cyano, azido or guanido group, or is unsaturated.Type: ApplicationFiled: August 26, 2002Publication date: July 10, 2003Applicant: STARPHARMA LIMITEDInventors: Barry Ross Matthews, George Holan
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Patent number: 6464971Abstract: To inhibit, prophylactically or therapeutically, a bacterial, yeast, fungal, or parasitic agent in a patient, an effective amount of a dendrimer is administered to the patient, which dendrimer has a plurality of terminal groups, at least one of which has an anionic- or cationic-moiety covalently bonded or linked thereto. The anionic-containing moiety is not a disaccharide or oligosaccharide moiety, and, where the anionic-containing moiety is a neuraminic- or sialic acid-containing. moiety, it is modified in the 4-position by substitution with an amino, amido, cyano, azido or guanido group, or is unsaturated.Type: GrantFiled: May 8, 2001Date of Patent: October 15, 2002Assignee: Starpharma LimitedInventors: Barry Ross Matthews, George Holan
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Patent number: 6426067Abstract: For proposes of prophylactic or treatment of diseases related to inappropriate angiogenesis, a compound can be administered that is (i) a linear, non-carbohydrate polymer having a plurality of side chain groups or (ii) a dendrimer having a plurality of terminal groups. At least one of the side chain groups of the linear, non-carbohydrate polymer has an anionic- or cationic-containing moiety bonded or linked thereto. The plurality of terminal groups of the dendrimer has at least one anionic- or cationic-containing moiety bonded or linked thereto.Type: GrantFiled: March 22, 1999Date of Patent: July 30, 2002Assignee: Biomolecular Research Institute, Ltd.Inventors: Barry Ross Matthews, George Holan
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Publication number: 20020025919Abstract: An antiviral compound comprises a linear non-carbohydrate polymer having a plurality of side chain groups, wherein at least one of the side chain groups has an anionic-or cationic-containing moiety bonded or linked thereto.Type: ApplicationFiled: August 15, 2001Publication date: February 28, 2002Inventors: Barry Ross Matthews, George Holan
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Patent number: 6190650Abstract: An antiviral compound comprises a dendrimer such as a polyamidoamine or polyly sine dendrimer having a plurality of terminal groups, wherein at least one of the terminal groups has an anionic- or cationic-containing moiety bonded thereto, particularly a sulfonic acid-containing, carboxylic acid-containing or trimethylammonium-containing moiety or the like.Type: GrantFiled: April 28, 1997Date of Patent: February 20, 2001Assignee: Biomolecular Research Institute Ltd.Inventors: Barry Ross Matthews, George Holan
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Patent number: 4849450Abstract: Compounds with arthropodicidal activity having the general formula (I); ##STR1## wherein R.sup.1 is a halo group; or a lower alkyl, lower alkoxy or lower alkylthio group, in each of which the alkyl group may be substituted with one or more halo groups; R.sup.2 is hydrogen or a halo or methyl group; or R.sup.1 and R.sup.2 together form a methylenedioxy, or a difluoro-methylenedioxy group or, R.sup.1 and R.sup.2 together with the carbon atoms to which they are attached, form an aromatic ring; R.sup.3 is hydrogen, CN, or C.ident.CH; Y is --CH-- or --N--; Z is H or F; and X.sup.1, X.sup.2, X.sup.3, and X.sup.4 are the same or different and each is hydrogen or a fluoro, bromo or chloro group; with the proviso that Y is --N-- when Z is H.Type: GrantFiled: May 1, 1987Date of Patent: July 18, 1989Assignee: Dunlena Pty. Ltd.Inventors: George Holan, Reimund A. Walser, Bryan C. Elmes
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Patent number: 4753960Abstract: Compounds with anthropodicidal activities having the general formula (1) ##STR1## and their isomeric forms wherein R represents F, Cl, Br, ethoxy, methoxy or propxy and n is an integer between 1 and 5; or R represents 3,4-methylenedioxyl; and R.sup.40 represents di- or trichloromethyl, fluorodichloromethyl or trifluoromethyl.Type: GrantFiled: March 10, 1986Date of Patent: June 28, 1988Assignee: Dunlena Pty. Ltd.Inventors: George Holan, Kurt Rihs, Wynona M. P. Johnson
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Patent number: 4540710Abstract: The (-)(-) diastereoisomers of the .alpha.-cyano-3-phenoxybenzyl and .alpha.-ethynyl-3-phenoxybenzyl esters of 1-(4-ethoxyphenyl)-, 1-(4-chlorophenyl)-, and 1-(3,4-methylenedioxyphenyl)-2,2,3,3-tetrafluorocyclobutane carboxylic acid.Type: GrantFiled: March 8, 1983Date of Patent: September 10, 1985Assignee: The Commonwealth Scientific and Industrial Research OrganizationInventors: George Holan, Reimund A. Walser
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Patent number: 4474815Abstract: Compounds of the general formula (I) ##STR1## wherein R represents F, Cl, Br, I, ethoxy, methoxy or propoxy and n is an integer between 1 and 5; orR represents 3,4-methylenedioxy; andR.sup.1 represents di- or tri-chloromethyl.The compounds have arthropodicidal (especially insecticidal and acaricidal) activity.Type: GrantFiled: April 2, 1982Date of Patent: October 2, 1984Assignee: Commonwealth Scientific and Industrial Research OrganizationInventors: George Holan, Wynona M. P. Johnson
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Patent number: 4391820Abstract: The (-) (-) diastereoisomers of the .alpha.-cyano-3-phenoxybenzyl and .alpha.-ethynyl-3-phenoxybenzyl esters of 1-(4-ethoxyphenyl)-, 1-(4-chlorophenyl)-, and 1-(3,4-methylenedioxyphenyl)-2,2,3,3-tetrafluorocyclobutane carboxylic acid.Type: GrantFiled: June 2, 1981Date of Patent: July 5, 1983Assignee: Commonwealth Scientific and Industrial Research OrganizationInventors: George Holan, Reimund Walser
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Patent number: 4390715Abstract: The (+), (-) and (.+-.) forms of the compounds of the general formula (I) ##STR1## characterized in that R.sup.1 is a halo group; or a lower alkyl, lower alkoxy or lower alkylthio group, each of which may be substituted with one or more halo groups;R.sup.2 is hydrogen or a methyl group; or R.sup.1 and R.sup.2 together form a methylenedioxy, or a difluoromethylenedioxy group or, with the carbon atoms to which they are attached, an aromatic or heteroaromatic ring; andA is one of the groups X or Y ##STR2## wherein X.sup.1 and X.sup.2 are the same or different and each is hydrogen or a fluoro, chloro, bromo or methyl group, with the proviso that if X.sup.1 is a fluoro group, then X.sup.2 should not be a bromo group; and X.sup.3 and X.sup.4 are the same or different and each is hydrogen or a fluoro group; andY.sup.1, Y.sup.2, Y.sup.3, Y.sup.4, Y.sup.5 and Y.sup.6 are the same or different groups and each is hydrogen or a fluoro, bromo, chloro, or methyl group.The compounds (I) are insecticidally active.Type: GrantFiled: July 10, 1981Date of Patent: June 28, 1983Assignee: Commonwealth Scientific and Industrial Research OrganizationInventors: George Holan, David F. O'Keefe
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Patent number: 4355042Abstract: Compounds of the general formula I ##STR1## wherein R.sup.1 is hydrogen or a methoxy, ethoxy, propoxy, butoxy, tetrafluoroethoxy, methylthio, ethylthio, propylthio, fluoro, chloro, bromo, methyl, ethyl, or nitro group, and R.sup.2 is hydrogen or a methyl group, orR.sup.1 and R.sup.2 together form a methylenedioxy group;R.sup.3 is hydrogen, or a lower alkyl group, or one of the following groups (a) to (f):(a) 3-phenoxybenzyl(b) 2-benzyl-4-furylmethyl(c) .alpha.-cyano-3-phenoxybenzyl(d) 3,4-methylenedioxybenzyl(e) .alpha.-ethynyl-3-phenoxybenzyl(f) .alpha.-cyano-3-(4'-chlorophenoxy)-benzyland Y.sup.1, Y.sup.2, Y.sup.3, Y.sup.4, Y.sup.5 and Y.sup.6 are the same or different groups and each is hydrogen or a fluoro, bromo or chloro group, with the proviso that when R.sup.1 is hydrogen, fluoro, chloro, bromo or methyl and R.sup.2 is hydrogen, then one of Y.sup.1 to Y.sup.6 is other than hydrogen.The compounds in which R.sup.3 is one of groups (a) to (f) are insecticides.Type: GrantFiled: October 9, 1980Date of Patent: October 19, 1982Assignee: Commonwealth Scientific and Industrial Research OrganizationInventors: George Holan, David F. O'Keefe
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Patent number: 4348409Abstract: Compounds of the general formula I ##STR1## wherein R.sup.1 is hydrogen or a methoxy, ethoxy, propoxy, butoxy, tetrafluoroethoxy, methylthio, ethylthio, propylthio, fluoro, chloro, bromo, methyl, ethyl, or nitro group, and R.sup.2 is hydrogen or a methyl group, or R.sup.1 and R.sup.2 together form a methylenedioxy group; R.sup.3 is hydrogen, or a lower alkyl group, or one of the following groups (a) to (f):(a) 3-phenoxybenzyl(b) 2-benzyl-4-furylmethyl(c) .alpha.-cyano-3-phenoxybenzyl(d) 3,4-methylenedioxybenzyl(e) .alpha.-ethynyl-3-phenoxybenzyl(f) .alpha.-cyano-3-(4'-chlorophenoxy)-benzyland Y.sup.1, Y.sup.2, Y.sup.3, Y.sup.4, Y.sup.5 and Y.sup.6 are the same or different groups and each is hydrogen or a fluoro, bromo or chloro group, with the proviso that when R.sup.1 is hydrogen, fluoro, chloro, bromo or methyl and R.sup.2 is hydrogen, then one of Y.sup.1 to Y.sup.6 is other than hydrogen.The compounds in which R.sup.3 is one of groups (a) to (f) are insecticides.Type: GrantFiled: June 20, 1979Date of Patent: September 7, 1982Assignee: Commonwealth Scientific and Industrial Research OrganizationInventors: George Holan, David F. O'Keefe