Patents by Inventor George J. Brewer

George J. Brewer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GASTRORETENTIVE ORAL HIGH DOSE ZINC PREPARATIONS
    Publication number: 20110212189
    Abstract: A sustained-release zinc composition preferably includes potassium bicarbonate. A method of providing zinc to a subject in need of treatment includes administering to the subject an effective amount of a sustained-release zinc composition which preferably includes potassium bicarbonate.
    Type: Application
    Filed: November 1, 2010
    Publication date: September 1, 2011
    Applicant: ADEONA PHARMACEUTICALS, INC.
    Inventors: George J. BREWER, Steve H. KANZER, David A. NEWSOME
  • Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies
    Patent number: 7888389
    Abstract: Disclosed are copper-binding compounds with improved properties and methods of using such compounds in the prevention and treatment of angiogenic diseases, such as cancer. Advantages of the invention include the enhanced stability of the compounds, which is achieved without reduction in efficacy. Pharmaceutical compositions, therapeutic kits and combination treatment methods and uses are also provided.
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: February 15, 2011
    Assignee: The Regents of the University of Michigan
    Inventors: George J. Brewer, Sofia D. Merajver, Dimitri Coucouvanis
  • Copper lowering treatment of inflammatory and fibrotic diseases
    Patent number: 7758898
    Abstract: The present invention relates generally to the field of prophylaxis and therapy for inflammatory and/or fibrotic diseases which include responses to injuries. In particular, the present invention is related to agents that can bind or complex copper such as thiomolybdate, and to the use of these agents in the prevention and treatment of inflammatory and/or fibrotic diseases.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: July 20, 2010
    Assignee: The Regents of the University of Michigan
    Inventor: George J. Brewer
  • Methods and compositions for the treatment of angiogenic diseases
    Patent number: 7438931
    Abstract: Provided are agents that can bind to copper, and form a tripartite complex with protein, and the use of these agents in the prevention and treatment of diseases with a vascular component, such as solid tumors. Compositions and methods for combination therapy of these diseases, including cancer, as well as therapeutic kits, are also provided.
    Type: Grant
    Filed: March 9, 2004
    Date of Patent: October 21, 2008
    Assignee: The Regents of The University of Michigan
    Inventors: George J. Brewer, Sofia D. Merajver, Dimitri Coucouvanis
  • Copper Lowering Treatment Of Cardiac Disease
    Publication number: 20080213396
    Abstract: The present invention relates generally to the field of prophylaxis and therapy for cardiac fibrosis. In particular, the present invention is related to agents that can bind or complex copper, and to the use of these agents in the prevention and treatment of cardiac damage caused by chemotherapeutic and pharmaceutical agents.
    Type: Application
    Filed: January 8, 2008
    Publication date: September 4, 2008
    Applicant: The Regents of the University of Michigan
    Inventor: George J. Brewer
  • Copper lowering treatment of inflammatory and fibrotic diseases
    Patent number: 7416741
    Abstract: The present invention relates generally to the field of prophylaxis and therapy for inflammatory and/or fibrotic diseases which include responses to injuries. In particular, the present invention is related to agents that can bind or complex copper such as thiomolybdate, and to the use of these agents in the prevention and treatment of inflammatory and/or fibrotic diseases.
    Type: Grant
    Filed: February 14, 2005
    Date of Patent: August 26, 2008
    Assignee: The Regents of the University of Michigan
    Inventor: George J. Brewer
  • Copper lowering treatment of inflammatory and fibrotic diseases
    Publication number: 20080118519
    Abstract: The present invention relates generally to the field of prophylaxis and therapy for inflammatory and/or fibrotic diseases which include responses to injuries. In particular, the present invention is related to agents that can bind or complex copper such as thiomolybdate, and to the use of these agents in the prevention and treatment of inflammatory and/or fibrotic diseases.
    Type: Application
    Filed: May 29, 2007
    Publication date: May 22, 2008
    Inventor: George J. Brewer
  • Copper lowering treatment of inflammatory and fibrotic diseases
    Patent number: 6855340
    Abstract: The present invention relates generally to the field of prophylaxis and therapy for inflammatory and/or fibrotic diseases which include responses to injuries. In particular, the present invention is related to agents that can bind or complex copper such as thiomolybdate, and to the use of these agents in the prevention and treatment of inflammatory and/or fibrotic diseases.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: February 15, 2005
    Assignee: Regents of the University of Michigan
    Inventor: George J. Brewer
  • Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies
    Publication number: 20040259945
    Abstract: Disclosed are copper-binding compounds with improved properties and methods of using such compounds in the prevention and treatment of angiogenic diseases, such as cancer. Advantages of the invention include the enhanced stability of the compounds, which is achieved without reduction in efficacy. Pharmaceutical compositions, therapeutic kits and combination treatment methods and uses are also provided.
    Type: Application
    Filed: July 23, 2003
    Publication date: December 23, 2004
    Applicant: The Regents of The University of Michigan
    Inventors: George J. Brewer, Sofia D. Merajver, Dimitri Coucouvanis
  • DNA encoding canine von willebrand factor and methods of use
    Patent number: 6780583
    Abstract: The complete sequence of the canine von Willebrand Factor cDNA and deduced amino acid sequence is provided. The mutation which causes von Willebrand's Disease in Scottish Terriers, Doberman pinschers, Shetland sheepdogs, Manchester terriers and Poodles are also provided. Methods for detecting carriers of the defective vWF gene are also provided.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: August 24, 2004
    Assignee: Board of Trustees Operating Michigan State University
    Inventors: Patrick J. Venta, George J. Brewer, Vilma Yuzbasiyan-Gurkan, William D. Schall
  • DNA encoding canine von willebrand factor and methods of use
    Patent number: 6767707
    Abstract: The complete sequence of the canine von Willebrand Factor cDNA and deduced amino acid sequence is provided. The mutation which causes von Willebrand's Disease in Scottish Terriers, Doberman pinschers, Shetland sheepdogs, Manchester terriers and Poodles are also provided. Methods for detecting carriers of the defective vWF gene are also provided.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: July 27, 2004
    Assignee: University of Michigan
    Inventors: Patrick J. Venta, George J. Brewer, Vilma Yuzbasiyan-Gurkan, William D. Schall
  • Methods and compositions for the prevention or treatment of cancer
    Patent number: 6703050
    Abstract: Provided are agents that can bind to copper, and form a tripartite complex with protein, and the use of these agents in the prevention and treatment of diseases with a vascular component, such as solid tumors. Compositions and methods for combination therapy of these diseases, including cancer, as well as therapeutic kits, are also provided.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: March 9, 2004
    Assignee: The Regents of the University of Michigan
    Inventors: George J. Brewer, Sofia D. Merajver, Dimitri Coucouvanis
  • Copper lowering treatment of inflammatory and fibrotic diseases
    Publication number: 20040009237
    Abstract: The present invention relates generally to the field of prophylaxis and therapy for inflammatory and/or fibrotic diseases which include responses to injuries. In particular, the present invention is related to agents that can bind or complex copper such as thiomolybdate, and to the use of these agents in the prevention and treatment of inflammatory and/or fibrotic diseases.
    Type: Application
    Filed: May 23, 2003
    Publication date: January 15, 2004
    Applicant: The Regents of the University of Michigan
    Inventor: George J. Brewer
  • DNA encoding canine von willebrand factor and methods of use
    Publication number: 20020137051
    Abstract: The complete sequence of the canine von Willebrand Factor cDNA and deduced amino acid sequence is provided. The mutation which causes von Willebrand's Disease in Scottish Terriers, Doberman pinschers, Shetland sheepdogs, Manchester terriers and Poodles are also provided. Methods for detecting carriers of the defective vWF gene are also provided.
    Type: Application
    Filed: June 21, 2001
    Publication date: September 26, 2002
    Applicant: The Regents of the University of michigan Board of Trustees operating MN State University
    Inventors: Patrick J. Venta, George J. Brewer, Vilma Yuzbasiyan-Gurkan, William D. Schall
  • DNA encoding canine von Willebrand factor and methods of use
    Patent number: 6410237
    Abstract: The complete sequence of the canine von Willebrand Factor cDNA and deduced amino acid sequence is provided. The mutation which causes von Willebrand's Disease in Scottish Terriers, a single base deletion in exon 4, has also been determined. Methods for detecting carriers of the defective vWF gene are also provided.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: June 25, 2002
    Assignees: Board of Trustees operating Michigan State University, The Regents of the University of Michigan
    Inventors: George J. Brewer, Patrick J. Venta, Vilma Yuzbasiyan-Gurkan, William D. Schall
  • DNA encoding canine von Willebrand factor and methods of use
    Patent number: 6074832
    Abstract: The complete sequence of the canine von Willebrand Factor cDNA and deduced amino acid sequence is provided. The mutation which causes von Willebrand's Disease in Scottish Terriers, Doberman pinschers, Shetland sheepdogs, Manchester terriers and Poodles are also provided. Methods for detecting carriers of the defective vWF gene are also provided.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: June 13, 2000
    Assignee: The Regents of the University of Michigan
    Inventors: Patrick J. Venta, George J. Brewer, Vilma Yuzbasiyan-Gurkan, William D. Schall, John Duffendeck
  • DNA encoding von Willebrand factor and methods of use
    Patent number: 6040143
    Abstract: The complete sequence of the canine von Willebrand Factor cDNA and deduced amino acid sequence is provided. The mutation which causes von Willebrand's Disease in Scottish Terriers, a single base deletion in exon 4, has also been determined. Methods for detecting carriers of the defective vWF gene are also provided.
    Type: Grant
    Filed: July 18, 1997
    Date of Patent: March 21, 2000
    Assignee: The Regents of the University of Michigan
    Inventors: Patrick J. Venta, George J. Brewer, Vilma Yuzbasiyan-Gurkan, William D. Schall