Abstract: Apparatus for interfacing a liquid chromatograph (LC) with a spectrometer such as a Fourier transform infrared spectrometer, the LC having an eluant, the eluant containing a solvent and a component of interest. The apparatus includes five basic parts. The first is a means for generating a stream of droplets of the eluant, such as a nebulizer. The second is a means for removing most of the solvent from the stream of droplets of the eluant to thereby generate a stream of particles, the particles containing the component of interest and any residual solvent, such as a membrane solvent separator/momentum separator combination. The third is a cryogenic receiving surface, such as a gold drum.

Abstract: Method of quantitatively determining chloromethyl methyl ether and/or bis-chloromethyl ether at greater sensitivity comprising utilizing an alkali metal salt of a lower alcohol and a readily detectable organic hydroxy compound in lower alcohol medium in a salt-to-hydroxy compound molar ratio of from about 0.2:1 to about 5:1 to react, when warmed, with either or both of said ethers, to form derivatives thereof; adding water to the reaction mixture and an immiscible hydrocarbon solvent; agitating and partitioning the mixture and directing at least a portion of the immiscible organic solvent extract onto a suitable gas chromatograph, preferably packed with glass beads with a stationary liquid phase thereon and more preferably with the beads coated with OV275 as the liquid phase; and eluting the reaction product or products off the column and through a detector therefor with an inert gas.