Patents by Inventor George J. Poiani

George J. Poiani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor
    Patent number: 6517824
    Abstract: A method for treating pulmonary hypertension and other diseases involving a defect in collagen metabolism, by administration of an effective amount of a liposome encapsulated copolymer conjugate antifibrotic composition, is disclosed. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). Consistent, high loadings (>98%) of the antifibrotic agent are achieved by first forming a dipeptide with L-lysine, after which the dipeptide is copolymerized with the polymer component to form the copolymer conjugate. The polymer is preferably poly(ethylene glycol) having a weight average molecular weight of from about 500 to about 15,000. There is thus provided the efficient delivery and rateable release of the antifibrotic agent to inhibit collagen accumulation and thereby treat the diseases involved.
    Type: Grant
    Filed: May 20, 1996
    Date of Patent: February 11, 2003
    Assignees: University of Medicine & Denistry of New Jersey, Rutgers University
    Inventors: Joachim Kohn, John E. Kemnitzer, III, George J. Poiani, David J. Riley
  • Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use
    Patent number: 5720950
    Abstract: The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collagen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.
    Type: Grant
    Filed: June 15, 1994
    Date of Patent: February 24, 1998
    Assignee: University of Medicine & Dentistry of New Jersey
    Inventors: George J. Poiani, David J. Riley, Wei-Chi Liao, Joachim Kahn, Keria Fiorella Gean
  • Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use
    Patent number: 5660822
    Abstract: The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collegen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 26, 1997
    Assignees: University of Medicine & Dentistry of N.J., Rutgers University
    Inventors: George J. Poiani, David J. Riley, Wei-Chi Liao, Joachim Kahn, Keria Fiorella Gean
  • Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use
    Patent number: 5372807
    Abstract: The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collegen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.
    Type: Grant
    Filed: August 24, 1992
    Date of Patent: December 13, 1994
    Assignees: University of Medicine and Dentistry of New Jersey, Rutgers University
    Inventors: George J. Poiani, David J. Riley, Wei-Chi Liao, Joachim Kahn, Keria F. Gean