Patents by Inventor George Johns

George Johns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190323050
    Abstract: Methods and apparatus of modulating polynucleotide synthesis are provided. The methods include delivering reagents comprising enzymes, nucleotides and ions to oligonucleotide primers wherein the reagents catalyze incorporation of the nucleotides to 3? ends of the oligonucleotide primers, and modulating incorporation of the nucleotides to the 3? ends of the oligonucleotide primers. Polynucleotide synthesis is modulated by modulating presence or absence of catalytic cation cofactors to provide sequence defined synthesis of polynucleotides. In certain embodiments, the polynucleotides encode information.
    Type: Application
    Filed: December 21, 2017
    Publication date: October 24, 2019
    Applicant: President and Fellows of Harvard College
    Inventors: Kettner John Frederick Griswold, Jr., Howon Lee, George M. Church
  • Publication number: 20190281816
    Abstract: The present invention relates to a formulation for promoting non-spontaneous formation (nucleation) of ice during freeze processing of a water-containing quantity of a biological entity which comprises a framework silicate mineral capable of acting as an ice nucleant and an ammonium salt.
    Type: Application
    Filed: May 12, 2017
    Publication date: September 19, 2019
    Inventors: Benjamin John Murray, Thomas Francis Whale, Theodore William Wilson, George John Morris
  • Publication number: 20190276405
    Abstract: Crystals of [8-chloro-3-(4-chlorobenzyl)-4-difluoromethoxy-2-ethylquinolin-5-yloxy]acetic acid L-lysine salt, i.e., a crystal A which has peaks at diffraction angles 2?=6.0°, 10.0°, 10.7°, 12.1°, 18.4°, 19.2° and 20.1° in powder X-ray diffraction spectra and a crystal B which has peaks at diffraction angles 2?=6.0°, 11.7°, 12.4°, 15.2°, 16.4°, 20.3° and 22.6° in powder X-ray diffraction spectra. These crystals are chemically stable and have excellent thermal stability and physical properties, and are therefore suitable as medicinal substances.
    Type: Application
    Filed: May 15, 2017
    Publication date: September 12, 2019
    Inventors: Donald John Daley, John Gary Montana, George Hynd, Mitsuru Teramoto, Takahiro Ito, Taro Tameyama
  • Publication number: 20190277601
    Abstract: An optical sighting assembly including an improved scope body and detachable accessories is presented. The accessories can be magnetically attachable to the scope body and can include a lens cartridge, a light pack, power pack and/or an alignment ring. The lens cartridge can be keyed to be installed at a predetermined rotational orientation, and the lens cartridge can hold a small diameter lens. Lenses can include a fluorescent aiming point that can fluoresce due to ambient light and/or when illuminated by an LED. The light pack can include the LED, a power source, and a control interface for adjusting light output. Alternatively, the LED can be integrated into the scope body, and a battery pack can include a power source and a control interface for the LED.
    Type: Application
    Filed: March 6, 2019
    Publication date: September 12, 2019
    Inventors: Kolby John Hanley, George Dewey Ryals, IV, Zachary Bruce Harris
  • Publication number: 20190273985
    Abstract: An omni-directional acoustic deflector includes an acoustically reflective body having a substantially conical outer surface, and an inner surface opposite the outer surface. The inner surface defines a region that is configured to be coupled to a first electronic component such that heat is transferred from the first electronic component to the outer surface of the acoustically reflective body.
    Type: Application
    Filed: May 22, 2019
    Publication date: September 5, 2019
    Applicant: Bose Corporation
    Inventors: Jason L. Katz, Richmond Andrew Real, Karl Edward Jacobson, Steven Carl Pletcher, George E.P. Chute, Christopher John Breen, Kyle Brian McNicholas
  • Patent number: 10399859
    Abstract: Described herein are methods and compositions for zeolite synthesis. The methods and compositions involve modifying a colloidal silica sol with a metal compound and in the presence of a structure directing agent, followed by heating to form a zeolite. The methods and compositions result in rapid zeolite formation, even at reduced concentrations of structure directing agent.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: September 3, 2019
    Assignee: Ecolab USA Inc.
    Inventors: Francois Batllo, Wenyong Lin, Yulia Tataurova, George Salomon, Shiby John
  • Publication number: 20190263782
    Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.
    Type: Application
    Filed: May 8, 2019
    Publication date: August 29, 2019
    Applicant: Genzyme Corporation
    Inventors: Jorgen Blixt, Michael David Golden, Philip John Hogan, David Michael Glanville Martin, Francis Joseph Montgomery, Zakariya Patel, John David Pittam, George Joseph Sependa, Christopher John Squire, Nicholas Cartwright Alexander Wright
  • Patent number: 10363053
    Abstract: A system comprised of custom radiographically designed tibial and talar cutting guides, a tibial reaming guide and bit, and instrumentalities for use in total ankle replacement surgery and a computer-based system and method for making the custom radiographically designed tibial and talar cutting guides.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: July 30, 2019
    Inventor: George John Lian
  • Patent number: 10344015
    Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilizing said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: July 9, 2019
    Assignee: Genzyme Corporation
    Inventors: Jorgen Blixt, Michael David Golden, Philip John Hogan, David Michael Glanville Martin, Francis Joseph Montgomery, Zakariya Patel, John David Pittam, George Joseph Sependa, Christopher John Squire, Nicholas Cartwright Alexander Wright
  • Patent number: 10328218
    Abstract: A nebulizer system includes a body having a fluid chamber and an aerosol chamber, and a vibrator assembly positioned at an interface between the fluid chamber and the aerosol chamber. The vibrator assembly may include a diaphragm, having a fluid side and an aerosol side, defining a plurality of perforations between the fluid side and the aerosol side, and one or more vibrator elements operatively associated with the diaphragm to vibrate the diaphragm to produce aerosolized medicament projected into the aerosol chamber from the plurality of perforations. Each perforation of the plurality of perforations projects the aerosolized medicament along a respective projection path relative to a plane defined by the aerosol side of the perforation, the one or more vibrator elements or the diaphragm support substrate further being configured to angularly displace the aerosol side of the diaphragm to sweep the direction of at least one projection path.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: June 25, 2019
    Assignee: ENGINEERED MEDICAL SYSTEMS, INC.
    Inventors: George Ashford Reed, Jeffrey John Quinn, Brad Hayden Quinn, Patrick Finn Boileau
  • Publication number: 20190185103
    Abstract: A hydraulic rotary steering damper with articulate linkage to enable mounting to a vehicle's steering mechanism coaxially, non-coaxially, or at an angle to the axis of steering rotation of the vehicle with the option of a hinged frame mount to attach to a vehicle's frame for the purpose of linking the steering damper to the vehicle's frame.
    Type: Application
    Filed: December 14, 2017
    Publication date: June 20, 2019
    Inventor: George John Athanasiou
  • Publication number: 20190187341
    Abstract: An optical system including a first microstructured surface; and a second microstructured surface; wherein the first microstructured surface is aligned along an axis with the second microstructured surface is provided. An illumination system including a light source and the optical system is also included. A method of diffusing light is included.
    Type: Application
    Filed: December 13, 2018
    Publication date: June 20, 2019
    Applicant: VIAVI SOLUTIONS INC.
    Inventors: Stephen H. CHAKMAKJIAN, George Michael MORRIS, Bradley John WARD, Tasso R. M. SALES
  • Publication number: 20190178702
    Abstract: A method for monitoring the mass of an object (10) is provided, the method comprising the steps of: (i) applying a vibratory force to the object (10) so that the object vibrates in whole or in part, (ii) providing a sensor or sensors (14) configured to measure vibrations of the object in response to the force, (iii) measuring vibration data from the sensor(s) (14), and (iv) comparing the vibration data or a parameter derived therefrom to reference data or one or more reference parameters, so as to determine the mass of the object or an indication that the mass of the object (10) differs from that indicated by the reference data or one or more reference parameters. Preferably, the object (10) is a vehicle. The vibratory force may be provided by an integral vehicle component, for example a vehicle engine (12).
    Type: Application
    Filed: December 7, 2017
    Publication date: June 13, 2019
    Inventors: Simon John Holden, Joseph Spencer, George Winstone
  • Patent number: 10316607
    Abstract: A pressure containment device includes a sealing element. The sealing element includes a longitudinal axis, a substantially annular cross-section arranged perpendicular to the longitudinal axis, a radially inwardly facing interior surface having a plurality of recesses, a radially outwardly facing exterior surface, a first end surface having a plurality of recesses, and a second end surface. The first end surface and the second end surface are each arranged to extend from the radially inwardly facing interior surface to the radially outwardly facing exterior surface. The first end surface and the second end surface are arranged at opposite ends of the sealing element.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: June 11, 2019
    Assignee: MANAGED PRESSURE OPERATIONS PTE. LTD.
    Inventors: Christian Leuchtenberg, Alexander John MacGregor, George Michaud, Saravanan Sundaramoorthy
  • Publication number: 20190174174
    Abstract: Disclosed are various embodiments to automatically generate network pages from extracted media content. In one embodiment, it is determined that a first facial expression of a face appearing in a frame of a digitally encoded video matches a second facial expression specified in a media extraction rule. The frame of the digitally encoded video is selected in response to the determination that the first facial expression matches the second facial expression. A user interface is generated that includes an image extracted from the selected frame of the digitally encoded video.
    Type: Application
    Filed: February 7, 2019
    Publication date: June 6, 2019
    Inventors: PIERS GEORGE COWBURN, JAMES WILLIAM JOHN CUMBERBATCH, ERIC MICHAEL MOLITOR, JOSHUA CERI RUSSELL-HOBSON
  • Patent number: 10306356
    Abstract: An omni-directional acoustic deflector includes an acoustically reflective body having a substantially conical outer surface, and an inner surface opposite the outer surface. The inner surface defines a region that is configured to be coupled to a first electronic component such that heat is transferred from the first electronic component to the outer surface of the acoustically reflective body.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: May 28, 2019
    Assignee: Bose Corporation
    Inventors: Jason L. Katz, Richmond Andrew Real, Karl Edward Jacobson, Steven Carl Pletcher, George E. P. Chute, Christopher John Breen, Kyle Brian Mcnicholas
  • Patent number: 10285416
    Abstract: A first edible layer is placed atop a tray and inside a first annular member, leaving an annular gap around the edible layer. A spreadable material is spread atop and laterally on the first edible layer. A second annular member is stacked upon the first annular member with a second edible layer centered in the second member but with an annular gap between the two. Spreadable material atop and laterally to the second edible layer. The annular members each have an overall transverse dimension greater than its height. These members are part of a reusable kit with the first member has an outwardly projecting pair of handles A tool for shaping spreadable material is shown as a plate with an opposite pair of finishing edges, one being straight, the other undulating. The lower edge of the tool is located between the finishing edges, and has an opposite pair of guide notches. Each of the notches can be pressed against the edge of the tray to regulate the tool's working depth.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: May 14, 2019
    Inventor: George John Lipari
  • Patent number: 10289912
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for classifying videos using neural networks. One of the methods includes obtaining a temporal sequence of video frames, wherein the temporal sequence comprises a respective video frame from a particular video at each of a plurality time steps; for each time step of the plurality of time steps: processing the video frame at the time step using a convolutional neural network to generate features of the video frame; and processing the features of the video frame using an LSTM neural network to generate a set of label scores for the time step and classifying the video as relating to one or more of the topics represented by labels in the set of labels from the label scores for each of the plurality of time steps.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: May 14, 2019
    Assignee: Google LLC
    Inventors: Sudheendra Vijayanarasimhan, George Dan Toderici, Yue Hei Ng, Matthew John Hausknecht, Oriol Vinyals, Rajat Monga
  • Patent number: 10280569
    Abstract: A golf course bunker drainage system has been developed that is a modular structure taking the form of a plurality of porous bunker paver blocks formed of material exhibiting vertical and horizontal infiltration rates at least the same as bunker sand. The plurality of porous bunker paver blocks is disposed as a boundary layer between a bunker subsoil bottom surface and overlying bunker sand, allowing rainwater to drain into the subsoil, with excess rainwater directed away from the bunker sand. The use of bunker paver blocks also maintains the integrity of the bunker shape and prevents movement of sand and other materials along steeply sloping bunker sidewalls.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: May 7, 2019
    Inventor: George John Skawski, Jr.
  • Patent number: 10258072
    Abstract: A gel is disclosed that is formed from a hydrophobic liquid and a gelator. The gelator has a structure given by: formula (I) where (II) and (III) or (IV) or (V). The gelator is environmentally friendly and from a biomass source.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: April 16, 2019
    Assignee: Research Foundation of the City University of New York
    Inventors: George John, Julian Silverman