Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: A node of a database system is operable to determine, at a first time, to prepare for a shutdown. The shutdown of the node is performed at a second time that is a period of time after the first time based on the node delaying the shutdown until a plurality of currently running processes being run by the node that initiated prior to the first time are determined to be complete. During the period of time after the first time and prior to performing the shutdown, a set of new processing requests are rejected by the node.

Abstract: Various aspects of the disclosure relate to monitoring a physical location to determine and/or predict anomalous activities. One or more machine learning algorithms may be used to analyze inputs from one or more sensors, cameras, audio recording equipment, and/or any other types of sensors to detect anomalous measurements/patterns. Notifications may be sent one or more devices in a network based on the detection.

Abstract: An interactive toy comprising a function device for performing user-perceptible, controllable functions. The interactive toy also includes a rechargeable power source and a charging circuit for contactless receipt of electrical energy and for charging the rechargeable power source when the interactive toy is positioned in a charging zone of a contactless charging device. The interactive toy is adapted to determine a charging rate at respective positions relative to the charging device and to generate a user-perceptible output indicative of the determined charging rate.

Abstract: A method for treating a hangover, comprising of administering to a subject in need a powdered or liquid juice product containing juiced ingredients of red onion, cucumber, and romaine lettuce. Other embodiments contain onion, cucumber, and one or more of any other leafy green vegetable. The components of the applicant's invention create a novel synergistic effect because the combination creates a greater effect than the sum of the effects of the components separately.

Abstract: An EEG headgear assembly for placement on the head of a subject which includes headgear formed from elastic straps and wired electrodes. The electrodes are secured to the headgear by means of elastic pockets which press an electrode head toward a subjects skin.

Abstract: A powdered or liquid juice product for hangover treatment containing juiced ingredients of red onion, cucumber, and romaine lettuce. Other embodiments contain onion, cucumber, and one or more of any other leafy green vegetable. The components of the applicant's invention create a novel synergistic effect because the combination creates a greater effect than the sum of the effects of the components separately.

Abstract: A device for performing EEG which consists of an elastic head strap, electrodes, and a wireless transmitter. The wireless transmitter, which displays indicators of electrode impedance, is secured to a patient using a docking station attached to the head strap at the crown of a subject's head and is placed into electrical communication with the electrodes using conductive thread sewn into the head strap. A simplified user interface comprising graphical elements improves the detection of brain wave patterns.

Abstract: A juice drink for hangover treatment containing juiced ingredients of red onion, cucumber, and a leafy green vegetable, such as romaine lettuce to treat a hangover after consumption of alcohol.

Abstract: A device for performing EEG which consists of an elastic head strap, electrodes, and a wireless transmitter. The wireless transmitter, which displays indicators of electrode impedance, is secured to a patient using a docking station attached to the head strap at the crown of a subject's head and is placed into electrical communication with the electrodes using conductive thread sewn into the head strap. A simplified user interface comprising graphical elements improves the detection of brain wave patterns.

Abstract: A carboy has a rigid body forming an interior chamber for receiving a liquid. The chamber has a wall terminating at an opening and maintains a substantially constant shape at room temperature. The carboy also has a closure permanently secured to the opening for forming a sealed connection with the rigid body, and a plurality of tubes extending from the plurality of ports in the closure to fluidly connect with a carboy circuit. The closure has a plurality of ports for selectively providing access to the interior chamber, where at least one of the tubes extends out of the interior chamber. The at least one tube also extends inwardly from the closure and into the interior chamber.

Abstract: A water treatment apparatus which facilitates the installation of a water treatment unit and prefilter into an existing plumbing system. The apparatus includes a bypass valve interconnected with a prefilter and water treatment unit using a connection box. The fittings and orientations are chosen for the components so that various configurations and orientations can be easily accommodated and with a minimum of parts. The apparatus eliminates the need for fabricating conduit segments, etc. at the installation site. The apparatus for connecting a water treatment unit to a water distribution system includes a control valve having spaced apart inlet and outlet ports and a connection module defining first and second flow passages. The first flow passage extends between first and second external ports and the second flow passage extends between third and fourth external ports. The first and third external ports are arranged and configured to correspond to the configuration and.

Abstract: A water treatment system for removing hard ions from source water. The water treatment system is of the type that includes a pair of ion-exchange water softener tanks connectable to a source of pressurized water and with a water system to supply softened water to the water system, the tanks each being capable of regeneration by flushing with a regeneration solution to replenish depleted ions. A process for preventing system failure due to salt crystallization includes flowing water during brine replenishment from a second nozzle and a first nozzle at a defined ratio. The first nozzle diluted the brine in a reservoir after regeneration cycle is complete. The second nozzle replenishes brine by flowing water directly onto a salt material.

Abstract: A water treatment system for removing hard ions from source water. The water treatment system is of the type that includes a pair of ion-exchange water softener tanks connectable to a source of pressurized water and with a water system to supply softened water to the water system, the tanks each being capable of regeneration by flushing with a regeneration solution to replenish depleted ions. A process for preventing system failure due to salt crystallization includes flowing water during brine replenishment from a second nozzle and a first nozzle at a defined ratio. The first nozzle diluted the brine in a reservoir after regeneration cycle is complete. The second nozzle replenishes brine by flowing water directly onto a salt material.

Abstract: A method and system for automated real time interpretation of brain waves in an acute brain injury of a patient using correlations between brain wave frequency power ratio and wave morphology, determined by a measure of the rhythmicity and variability of the brain wave as a function of the slope of the brain wave upstroke, the arc of the brain wave, and the synchronicity of the brain wave. A system is provided with a central processing unit (16), an electroencephalogram acquisition unit (18), a reference database (24), a quantitative electroencephalogram analysis program (14), and a display device (26) for communicating the classification of the acquired electroencephalographic signals. Artifact rejection is also provided.

Abstract: A water treatment system for removing hard ions from source water. The water treatment system is of the type that includes a pair of ion-exchange water softener tanks connectable to a source of pressurized water and with a water system to supply softened water to the water system, the tanks each being capable of regeneration by flushing with a regeneration solution to replenish depleted ions. A process for preventing system failure due to salt crystallization includes flowing water during brine replenishment from a second nozzle and a first nozzle at a defined ratio. The first nozzle diluted the brine in a reservoir after regeneration cycle is complete. The second nozzle replenishes brine by flowing water directly onto a salt material.

Abstract: An acquisition unit provided which provides a turn-key interface to the non-expert personnel who attend acutely brain-injured victims, preventing change or modification of the electroencephalogram parameters by the field technician, while at the same time allowing extensive control over parameters by a remote expert EEG reader; and a method and system is provided using the template and acquisition unit of the present invention with one of a plurality of remote readers who are part of a network of trained EEG readers.

Abstract: A method and system for automated real time interpretation of brain waves in an acute brain injury of a patient using correlations between brain wave frequency power ratio and wave morphology, determined by a measure of the rhythmicity and variability of the brain wave as a function of the slope of the brain wave upstroke, the arc of the brain wave, and the synchronicity of the brain wave. A system is provided with a central processing unit (16), an electroencephalogram acquisition unit (18), a reference database (24), a quantitative electroencephalogram analysis program (14), and a display device (26) for communicating the classification of the acquired electroencephalographic signals. Artifact rejection is also provided.

Abstract: An acquisition unit is provided which provides a turn-key interface to the non-expert personnel who routinely attend acutely brain-injured victims, preventing change or modification of the electroencephalogram parameters by the field technician, while at the same time allowing extensive control over parameters by a remote expert EEG reader; and a method and system is provided using the template and acquisition unit of the present invention with one of a plurality of remote readers who are part of a network of trained EEG readers.

Abstract: A template for placing electrodes for electroencephalography of acute-brain-injured victims is provided which modifies the number of electrode locations from that taught by the standard 10-20 System, and which has indicia that can be quickly and easily read by non-experts during emergency application; an acquisition unit is provided which provides a turn-key interface to the non-expert personnel who routinely attend acutely brain-injured victims, preventing change or modification of the electroencephalogram parameters by the field technician, while at the same time allowing extensive control over parameters by a remote expert EEG reader; and a method and system is provided using the template and acquisition unit of the present invention with one of a plurality of remote readers who are part of a network of trained EEG readers.