Patents by Inventor George L. Brode

George L. Brode has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6359102
    Abstract: Improvements are disclosed for biphasic polymerization processes in which an aqueous solution of a first monomer that is hydrolytically unstable below a pH of about six or above a pH of about eight is admixed with a water-immiscible organic solvent and there is added to the admixture a catalyst selected from tertiary amine, quaternary amine and phosphonium catalysts, an acid-forming co-monomer for the first monomer, an acid scavenger, after which the resulting polymer is recovered, wherein the improvement includes providing the aqueous solution at a pH between about si and about eight, and adding to the admixture the acid-forming co-monomer and the acid scavenger at relative rates effective to maintain the pH of the admixture between about six and about eight. The catalyst may be added in a molar ratio to the first monomer effective to provide a predetermined weight-average or number-average molecular weight for the resulting polymer.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: March 19, 2002
    Assignee: Integra LifeSciences I, Ltd.
    Inventors: John E. Kemnitzer, George L. Brode, Joachim B. Kohn
  • Patent number: 6120491
    Abstract: A polymer with a hydrolytically labile backbone and having the structure: ##STR1## wherein R.sub.9 is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendent carboxylic acid group or the benzyl ester thereof;R.sub.12 is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendent carboxylic acid ester group selected from straight and branched alkyl and alkylaryl esters containing up to 18 carbon atoms and ester derivatives of biologically and pharmaceutically active compounds covalently bonded thereto, provided that the ester group is not a benzyl group or a group that is removed by hydrogenolysis;each R.sub.7 is independently an alkylene group containing up to four carbon atoms;A is selected from: ##STR2## wherein R.sub.8 is selected from saturated and unsaturated, substituted and unsubstituted alkyl, aryl and alkylaryl groups containing up to 18 carbon atoms;k is between about 5 and about 3,000; andx and f independently range from zero to less that one.
    Type: Grant
    Filed: April 7, 1998
    Date of Patent: September 19, 2000
    Assignee: The State University Rutgers
    Inventors: Joachim B. Kohn, Durgadas Bolikal, George L. Brode, Sylvie I. Ertel, Shuiyun Guan, John E. Kemnitzer
  • Patent number: 5595980
    Abstract: Improved contraceptive compositions are disclosed which comprise a spermicide or virucide, a polymeric delivery component and optionally a cosmetic ingredient. The improvement is directed to the use of certain hydrophobically modified polysaccharides as the polymeric delivery component. Quite advantageously, the hydrophobically modified polysaccharides of the present invention can alter sperm motility. Moreover, the hydrophobically modified polysaccharides can provide reduced irritation potential when used in combination with spermicides such as, for example, nonoxynol-9, which may reduce the potential for infection of sexually transmitted diseases such as HIV and herpes.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: January 21, 1997
    Assignees: Medical College of Hampton Roads, Biomaterials Corporation
    Inventors: George L. Brode, Gustavo F. Doncel, Henry L. Gabelnick, Russell L. Kreeger, George A. Salensky
  • Patent number: 5407919
    Abstract: Double-substituted, water-soluble, cellulose ethers substituted with a cationic substituent and a hydrophobic substituent are disclosed. The levels of substitution for the cationic substituent and the hydrophobic substituent can provide enhanced properties when used in personal care compositions, such as, for example, enhanced substantivity, saline capability and low irritation potential to mucosal linings.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: April 18, 1995
    Inventors: George L. Brode, Russell L. Kreeger, George A. Salensky
  • Patent number: 5300494
    Abstract: The invention relates to a method for topical application of a pharmaceutically or therapeutically active agent through the use of a covalent chitosan derivative or chitosonium polymer. The present invention is particularly well suited for the topical delivery of pharmaceutically active quaternary ammonia compounds of the formula: ##STR1## wherein R is alkyl having between 5 and 11 carbon atoms.
    Type: Grant
    Filed: July 12, 1989
    Date of Patent: April 5, 1994
    Assignee: Union Carbide Chemicals & Plastics Technology Corporation
    Inventors: George L. Brode, II, George A. Salensky
  • Patent number: 5055114
    Abstract: Permeable membranes comprised predominantly of specifically defined tetrabromobisphenols and aromatic dicarboxylic acids. The invention also pertains to the novel permeation processes for recovery of an oxygen/nitrogen or carbon dioxide/methane component form a mixture of said component with other components.
    Type: Grant
    Filed: December 6, 1989
    Date of Patent: October 8, 1991
    Assignee: Union Carbide Industrial Gases Technology Corporation
    Inventors: James H. Kawakami, Natarajan Muruganandam, George L. Brode
  • Patent number: 4997643
    Abstract: A biocompatible, film-forming delivery system for the delivery of pharmaceutical or therapeutic actives to a desired topical site of a subject, the system including:an active salt compound, wherein the active salt compound is at least a partial salt of(1) a carboxylic acid moiety-containing, biocompatible, film-forming polymer with(2) at least one active selected from the group consisting of pharmaceutical actives, therapeutic actives and a combination thereof, wherein the at least one active is capable of complexing with at least one carboxylic acid moiety of the polymer to form the active salt compound, andwherein the active salt compound forms an active salt compound film on the topical site and the active salt compound disassociates into the polymer and the at least one active while the delivery system is in contact with the topical site such that the polymer remains thereon as a polymer film and the at least one active is delivered to the topical site in an absorbable form.
    Type: Grant
    Filed: July 12, 1989
    Date of Patent: March 5, 1991
    Assignee: Union Carbide Chemicals and Plastics Company Inc.
    Inventors: Emmett M. Partain, III, George L. Brode, II
  • Patent number: 4994095
    Abstract: Permeable membranes comprised predominantly of specifically defined polyester of 4,4'-(1H-alkylidene)bis[2,3,6-trialkylphenol] and aromatic dicarboxylic acids. The invention also pertains to the novel permeation processes for recovery of an oxygen/nitrogen or carbon dioxide/methane or helium/methane component from a mixture of said component with other components in the mixture.
    Type: Grant
    Filed: December 6, 1989
    Date of Patent: February 19, 1991
    Assignee: Union Carbide Industrial Gases Technology Corporation
    Inventors: James H. Kawakami, Natarajan Muruganandam, George L. Brode
  • Patent number: 4959432
    Abstract: Cationic, anionic and amphoteric polymers suitable for the preparation of acid viscosifier compositions and the acid viscosified compositions are provided. The polymers are water soluble or water dispersible and are based on acrylyl monomers having the stated ionic charge. They are capable of viscosifying acid solutions that have important use in recovery of gas and oil from subterranean formations.
    Type: Grant
    Filed: July 18, 1988
    Date of Patent: September 25, 1990
    Assignee: Union Carbide Chemicals and Plastics Company Inc.
    Inventors: You-Ling Fan, George L. Brode, James P. Stanley
  • Patent number: 4946870
    Abstract: Delivery systems containing at least one aminopolysaccharide derivative are provided for the delivery of pharmaceutical or therapeutic actives to a desired topical or mucous membrane site in a subject, and wherein upon delivery, the systems provides a biocompatible, substantive, gas permeable, film from which actives are available at the designated site.
    Type: Grant
    Filed: November 8, 1988
    Date of Patent: August 7, 1990
    Assignee: Union Carbide Chemicals and Plastics Company Inc.
    Inventors: Emmett M. Partain, III., George L. Brode, II.
  • Patent number: 4929722
    Abstract: Heterogeneous acid decrystallization of aminopolysaccharides, especially chitosen, using diluent, organic acid and water, provides novel salts and covalent derivatives useful in diverse applications including biomedicine, personal care and fluid separation.
    Type: Grant
    Filed: February 3, 1988
    Date of Patent: May 29, 1990
    Assignee: Union Carbide Chemicals and Plastics Company Inc.
    Inventors: Emmett M. Partain, III, George L. Brode, II
  • Patent number: 4913743
    Abstract: Combinations of glycosaminoglycan and certain cationic polymers provide modified glycosaminoglycan properties and can provide substantivity to keratinous material, compatibility, stability, humectancy, rheology and other properties useful in personal care or medical applications.
    Type: Grant
    Filed: May 25, 1988
    Date of Patent: April 3, 1990
    Assignees: Biomatrix, Inc., Union Carbide Chemicals and Plastics Company Inc.
    Inventors: George L. Brode, Philip A. Band, Errol D. Goddard, Arminda G. Barbone, Adolf Leshchiner, Joseph P. Pavlichko, Emmett Partain, III, Pak S. Leung
  • Patent number: 4889887
    Abstract: Gelable acid compositions containing novel crosslinkable copolymers and the novel copolymers. The copolymers contain an N-(alkoxymethylene)acrylyl moiety. In addition there are provided gelable acid compositions containing a group of polyfunctional reactants that contain a plurality of --CH.sub.2 OH and/or --CH.sub.2 CH.sub.2 OH groups in the molecule.
    Type: Grant
    Filed: February 22, 1988
    Date of Patent: December 26, 1989
    Assignee: Union Carbide Chemicals and Plastics Company Inc.
    Inventors: You-Ling Fan, James P. Stanley, George L. Brode
  • Patent number: 4873293
    Abstract: Partially hydrolyzed, poly(N-acyl alkylenimines), and novel nitrogen-substituted derivatives thereof, provide useful and improved personal care compositions and processes.
    Type: Grant
    Filed: March 9, 1989
    Date of Patent: October 10, 1989
    Assignee: Union Carbide Chemicals and Plastics Company Inc.
    Inventors: George L. Brode, II, Frederick M. Merritt, II
  • Patent number: 4837005
    Abstract: Partially hydrolyzed, poly(N-acyl)alkylenimines), and novel nitrogen-substituted derivatives thereof, provide useful and improved personal care compositions and processes.
    Type: Grant
    Filed: September 30, 1986
    Date of Patent: June 6, 1989
    Assignee: Union Carbide Corporation
    Inventors: George L. Brode, II, Frederick M. Merritt, II
  • Patent number: 4767463
    Abstract: Combinations of glycosaminoglycan and certain cationic polymers provide modified glycosaminoglycan properties and can provide substantivity to keratinous material, compatibility, stability, humectancy, rheology and other properties useful in personal care or medical applications.
    Type: Grant
    Filed: April 15, 1987
    Date of Patent: August 30, 1988
    Assignee: Union Carbide Corporation
    Inventors: George L. Brode, Philip A. Band, Errol D. Goddard, Arminda G. Barbone, Adolf Leshchiner, Joseph P. Pavlichko, Emmett M. Partain, III, Pak S. Leung
  • Patent number: 4760106
    Abstract: Described herein is a composition which contains a specific group of hardeners, an epoxy resin and a thermoplastic polymer. When combined with a structural fiber the composition produces composites which have improved impact resistance, improved tensile properties and high compressive properties.
    Type: Grant
    Filed: January 8, 1987
    Date of Patent: July 26, 1988
    Assignee: Amoco Corporation
    Inventors: Hugh C. Gardner, Michael J. Michno, Jr., George L. Brode, Robert J. Cotter
  • Patent number: 4727110
    Abstract: A process for the water-in-oil emulsion polymerization of at least one ethylenically-unsaturated water-soluble monomer is disclosed which comprises forming a water-in-oil emulsion of said monomer, forming a small amount of polymer of said monomer in said emulsion to obtain a shear stable emulsion and then completing the polymerization of the monomer.
    Type: Grant
    Filed: October 8, 1985
    Date of Patent: February 23, 1988
    Assignee: Union Carbide Corporation
    Inventors: You-Ling Fan, George L. Brode
  • Patent number: 4663159
    Abstract: Water-soluble, cationic polysaccharides, including quaternary nitrogen-containing cellulose ethers, containing hydrophobic substitution, are substantially water-soluble; provide aqueous solutions having enhanced viscosity, foaming and preferably improved surface properties; and possess utility in personal care, emulsions and cleansers.
    Type: Grant
    Filed: February 1, 1985
    Date of Patent: May 5, 1987
    Assignee: Union Carbide Corporation
    Inventors: George L. Brode, II, Russell L. Kreeger, Errol D. Goddard, Frederick M. Merritt, II, David B. Braun
  • Patent number: 4661559
    Abstract: Described herein is a composition which contains a specific group of hardeners, an epoxy resin and a thermoplastic polymer. When combined with a structural fiber the composition produces composites which have improved impact resistance, improved tensile properties and high compressive properties.
    Type: Grant
    Filed: January 10, 1985
    Date of Patent: April 28, 1987
    Assignee: Union Carbide Corporation
    Inventors: Hugh C. Gardner, Michael J. Michno, Jr., George L. Brode, Robert J. Cotter