Patents by Inventor George L. Mutter

George L. Mutter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6868342
    Abstract: The present invention represents a new approach to data analysis for multivariate classification, particularly as used in medical diagnostics. The invention is in part an intuitive decision making tool for rapid classification of “objects” (e.g., cell, tissue or tumor samples) from evaluation of many simultaneous “variables” (e.g., quantitative gene expression profiles). The data analysis methods of the invention provide the end user with a simplified and robust output for diagnostic classification of objects based on identifying and evaluating multiple variables of predetermined diagnostic relevance. The raw data generated by analysis of the variables is transformed by application or appropriate algorithms to scaleless rank differentials between the variables. The rank orders of variables are used to classify tissues based on readily observable user interfaces, such as a graphical (e.g., visual) user interface or an auditory user interface.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: March 15, 2005
    Assignee: The Brigham & Women's Hospital, Inc.
    Inventor: George L. Mutter
  • Patent number: 6773883
    Abstract: The invention provided sets of genes that are expressed differentially in normal and malignant endometrium. These sets of genes can be used to discriminate between normal and malignant endometrial tissues. Accordingly, diagnostic assays for classification of tumors, prediction of tumor outcome, selecting and monitoring treatment regimens and monitoring tumor progression/regression also are provided.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: August 10, 2004
    Assignee: The Brigham & Women's Hospital, Inc.
    Inventor: George L. Mutter
  • Patent number: 6703204
    Abstract: The invention provides particular sets of genes that are expressed differentially in tumors characterized as high MAI or low MAI tumors. These sets of genes can be used to discriminate between high and low MAI tumors. Diagnostic assays for classification of tumors, prediction of tumor outcome, selecting and monitoring treatment regimens and monitoring tumor progression/regression are also provided.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: March 9, 2004
    Assignee: The Brigham & Women's Hospital, Inc.
    Inventors: George L. Mutter, Jan P. A. Baak
  • Patent number: 6649359
    Abstract: The invention disclosed herein describes novel methods for diagnosing endometrial precancers by measuring PTEN expression and offers an immunohistochemical biomarker for premalignant disease.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: November 18, 2003
    Assignees: The Brigham & Women's Hospital, Inc., The Ohio State University
    Inventors: George L. Mutter, Charis Eng
  • Publication number: 20020143472
    Abstract: The present invention represents a new approach to data analysis for multivariate. classification, particularly as used in medical diagnostics. The invention is in part an intuitive decision making tool for rapid classification of “objects” (e.g., cell, tissue or tumor samples) from evaluation of many simultaneous “variables” (e.g., quantitative gene expression profiles). The data analysis methods of the invention provide the end user with a simplified and robust output for diagnostic classification of objects based on identifying and evaluating multiple variables of predetermined diagnostic relevance. The raw data generated by analysis of the variables is transformed by application or appropriate algorithms to scaleless rank differentials between the variables. The rank orders of variables are used to classify tissues based on readily observable user interfaces, such as a graphical (e.g., visual) user interface or an auditory user interface.
    Type: Application
    Filed: October 12, 2001
    Publication date: October 3, 2002
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventor: George L. Mutter
  • Publication number: 20020106662
    Abstract: The invention provided sets of genes that are expressed differentially in normal and malignant endometrium. These sets of genes can be used to discriminate between normal and malignant endometrial tissues. Accordingly, diagnostic assays for classification of tumors, prediction of tumor outcome, selecting and monitoring treatment regimens and monitoring tumor progression/regression also are provided.
    Type: Application
    Filed: July 31, 2001
    Publication date: August 8, 2002
    Inventor: George L. Mutter
  • Publication number: 20020061541
    Abstract: The invention disclosed herein describes novel methods for diagnosing endometrial precancers by measuring PTEN expression and offers an immunohistochemical biomarker for premalignant disease.
    Type: Application
    Filed: May 31, 2001
    Publication date: May 23, 2002
    Inventors: George L. Mutter, Charis Eng